The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis

Jiang, Jianhao; Gareev, Ilgiz; Ilyasova, Tatiana; Shumadalova, Alina; Du, Weijie; Yang, Baofeng

doi:10.1016/j.ncrna.2024.01.001

Non-coding RNA Research

2024

DOI: 10.1016/j.ncrna.2024.01.001

|View full text |Cite

The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis

Jianhao Jiang,

Ilgiz Gareev,

Tatiana Ilyasova

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Lnc-Clic5 as a sponge for miR-212–5p to inhibit cow barn PM2.5-induced apoptosis in rat alveolar macrophages

Sun,

et al. 2024

Toxicology

View full text Add to dashboard Cite

Lnc-Clic5 as a sponge for miR-212–5p to inhibit cow barn PM2.5-induced apoptosis in rat alveolar macrophages

Sun,

et al. 2024

Toxicology

View full text Add to dashboard Cite

Emerging advanced approaches for diagnosis and inhibition of liver fibrogenesis

Addissouky,

Ali,

Sayed

et al. 2024

Egypt J Intern Med

View full text Add to dashboard Cite

Background Liver fibrosis results from chronic liver injury and is characterized by excessive deposition of extracellular matrix proteins including collagen. It can progress to cirrhosis and liver failure. Main body of the abstract Multiple cellular signaling pathways drive hepatic stellate cell activation and fibrogenesis. Advances in biomarkers, imaging modalities, and omics platforms enable noninvasive diagnosis and staging of liver fibrosis. Emerging antifibrotic approaches include medications like pirfenidone, obeticholic acid, and monoclonal antibodies targeting pro-fibrotic mediators. Cell therapies using mesenchymal stem cells demonstrate antifibrotic potential through paracrine immunosuppression. Tissue-engineered liver grafts and biomaterial carriers for localized drug delivery are promising technologies. Microfluidic liver-on-a-chip platforms with patient-derived cells provide unprecedented models to study human liver fibrosis and test drug candidates. Short conclusion Significant progress has elucidated mechanisms underlying liver fibrogenesis and uncovered novel therapeutic targets. Ongoing challenges include translating preclinical findings, improving antifibrotic efficacy, and enabling personalized precision medicine approaches. Further research into combinatorial therapies, biomarkers, and tissue engineering technologies will advance the treatment of liver fibrosis from all causes.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis

Cited by 2 publications

References 59 publications

Lnc-Clic5 as a sponge for miR-212–5p to inhibit cow barn PM2.5-induced apoptosis in rat alveolar macrophages

Lnc-Clic5 as a sponge for miR-212–5p to inhibit cow barn PM2.5-induced apoptosis in rat alveolar macrophages

Emerging advanced approaches for diagnosis and inhibition of liver fibrogenesis

Contact Info

Product

Resources

About