The Role of LncRNA TUG1 in Obesity-related Diseases

Abstract

With the continuous improvement of living standards, obesity has become an inevitable hotspot in our daily life. It remains a chronic and recurrent disease with serious adverse consequences. Over the past few years, several articles suggested that long non-coding RNA taurine increased gene 1（lncRNA TUG1）, a useful RNA, was suggested to show a relationship to obesity-related disease occurrence and development. Exosome is an emerging research field, which contains substances that are actively involved in regulating the molecular mechanisms of disease. This review summarizes the current relevant TUG1 in different molecular pathways of diseases related to obesity, relationship between exosomes and TUG1 or diseases related to obesity. The aim is to explore TUG1 as a novel target for obesity, which can deepen the knowledge regarding epigenetic regulation pathway. Besides, it is likely to be a potential future targeting diseases related to obesity site treatment and diagnosis

LncRNA SNHG14/miR‐497a‐5p/BACE1 axis modulates obesity‐induced adipocyte inflammation and endoplasmic reticulum stress

“…Accumulated studies promulgate that lncRNAs are vital mediating molecules in obesity. Xue et al [ 22 ] illustrated that lncRNA taurine increased gene 1 is interrelated to obesity occurrence and is a novel obesity target. Liu et al [ 23 ] proved that lncRNA H19 is overexpressed in obesity induced by HFD, and interfering with lncRNA H19 protects obesity‐induced myocardial injury.…”

Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?

“…LncRNA taurine upregulated gene 1 (TUG1) was first identified as upregulated in developing retinal cells and in response to taurine (2-aminoethanesulfonie acid) [96]. This lncRNA is also implicated in other conditions, namely colorectal cancer and obesity-related diseases [97,98]. More recently, TUG1 was shown to have a poor expression in DVT mice.…”

Long Non-Coding RNAs in Cardiac and Pulmonary Fibroblasts and Fibrosis

“…To complicate the matter further, individual lncRNAs have been reported to sponge several miRNAs, as in the case of the lncRNA GAS5 (growth arrest specific 5), for miR-21 , miR-26a/b-5p , and miR-5325p in cardiac fibroblasts and fibrosis [ 47 , 48 , 49 , 50 ]. Another example is TUG1 , which sequesters miR-29b-3p , miR-29c , miR-133b , and miR-590 [ 45 , 46 , 51 , 52 ]. As there are more miRNAs being identified to bind these two exemplified lncRNAs in other cell types (e.g., cardiomyocytes, endothelial cells), cellular statuses, and diseases [ 51 , 52 , 53 , 54 , 55 , 56 , 57 ], it is important to perform a comparative study of lncRNAs and several miRNAs being reported to be sequestered by the target lncRNAs by measuring the copy numbers of each RNA species.…”

“…Another example is TUG1 , which sequesters miR-29b-3p , miR-29c , miR-133b , and miR-590 [ 45 , 46 , 51 , 52 ]. As there are more miRNAs being identified to bind these two exemplified lncRNAs in other cell types (e.g., cardiomyocytes, endothelial cells), cellular statuses, and diseases [ 51 , 52 , 53 , 54 , 55 , 56 , 57 ], it is important to perform a comparative study of lncRNAs and several miRNAs being reported to be sequestered by the target lncRNAs by measuring the copy numbers of each RNA species. Without such a head-to-head comparative study, more and more miRNAs will be reported to be sequestered by one lncRNA, despite its expression level being far lower than those of the sequestered miRNAs.…”