The role of long non-coding RNA H19 in infertility

Peng, Yuanyuan; Guo, Renhao; Shi, Bei; Li, Da

doi:10.1038/s41420-023-01567-y

Cited by 4 publications

(2 citation statements)

References 71 publications

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“…Notably, H19 hypermethylation has been associated with smoking [62]. On this basis, the methylations status of the ICR of the H19 gene has been suggested as an epigenetic biomarker of fertility in men with sperm abnormalities [63]. Sperm DNA from infertile males can also have methylation defects at H19 at the regulatory region CTCF-binding site 6 (CTCF6) located within the DMR of IGF2-H19 [64].…”

Section: Dna Methylation and Male Infertilitymentioning

confidence: 99%

A DNA Methylation Perspective on Infertility

Shacfe,

Turko,

Syed

et al. 2023

Genes

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Infertility affects a significant number of couples worldwide and its incidence is increasing. While assisted reproductive technologies (ART) have revolutionized the treatment landscape of infertility, a significant number of couples present with an idiopathic cause for their infertility, hindering effective management. Profiling the genome and transcriptome of infertile men and women has revealed abnormal gene expression. Epigenetic modifications, which comprise dynamic processes that can transduce environmental signals into gene expression changes, may explain these findings. Indeed, aberrant DNA methylation has been widely characterized as a cause of abnormal sperm and oocyte gene expression with potentially deleterious consequences on fertilization and pregnancy outcomes. This review aims to provide a concise overview of male and female infertility through the lens of DNA methylation alterations.

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Section: Dna Methylation and Male Infertilitymentioning

confidence: 99%

A DNA Methylation Perspective on Infertility

Shacfe,

Turko,

Syed

et al. 2023

Genes

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“…The roles of H19 in endometrial biology have been reviewed. 19,20 Also, the involvement of H19 in the development and functioning of the ovary 20,21 and the placenta 22 have been reviewed. However, the molecular mechanisms of H19 actions in the ovarian and placental micro-environments are yet to be characterized.…”

mentioning

confidence: 99%

Long noncoding RNA H19 in ovarian biology and placenta development

Adu‐Gyamfi,

Cheeran,

Salamah

et al. 2024

Cell Biochemistry & Function

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As the first long noncoding RNA to be discovered, H19 has gained substantial attention as a key regulator of several biological processes and its roles in female reproductive biology are gradually getting revealed. Herein, we have summarized the current evidence regarding H19 expression pattern and involvement in the developmental and pathological processes associated with the ovary and the placenta. The findings indicate that within the ovaries, H19 is expressed in the antral and cystic atretic follicles as well as in the corpora lutea but absent in the primordial, primary, and secondary follicles. Its normal expression promotes the maturation of antral follicles and prevents their premature selection for the ovulatory journey while its aberrant induction promotes polycystic ovary syndrome development and ovarian cancer metastasis. In the placenta, H19 is highly expressed in the cytotrophoblasts and extravillous trophoblasts but weakly expressed in the syncytiotrophoblast layer and potentially controls trophoblast cell fate decisions during placenta development. Abnormal expression of H19 is observed in the placental villi of pregnancies affected by pre‐eclampsia and fetal growth restriction. Therefore, dysregulated H19 is a candidate biomarker and therapeutic target for the mitigation of ovarian and placenta‐associated diseases.

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Role of LncRNA H19 in tumor progression and treatment

Li,

Gao,

et al. 2024

Molecular and Cellular Probes

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The role of long non-coding RNA H19 in infertility

Cited by 4 publications

References 71 publications

A DNA Methylation Perspective on Infertility

A DNA Methylation Perspective on Infertility

Long noncoding RNA H19 in ovarian biology and placenta development

Role of LncRNA H19 in tumor progression and treatment

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