The Role of Long Non-Coding RNAs in the Tumor Immune Microenvironment

Guo, Yingli; Xie, Yajuan; Luo, Yao

doi:10.3389/fimmu.2022.851004

Cited by 20 publications

(15 citation statements)

References 268 publications

(298 reference statements)

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“…Long non-coding RNA (lncRNA) and circular RNA (circRNA) are crucial types of ncRNAs that are sensitive to the tumor immune response. LncRNAs are involved in a variety of cellular processes and molecular signaling cascades via their modulation of PD-L1 expression at the epigenetic, transcriptional, and post-transcriptional levels [ 73 , 74 ]. Some circRNAs regulate the function of miRNAs as microRNA sponges and are essential to transcriptional regulation [ 75 ].…”

Section: Lncrna and Circrnamentioning

confidence: 99%

Current insight into the regulation of PD-L1 in cancer

Liu

et al. 2022

Exp Hematol Oncol

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The molecular mechanisms underlying cancer immune escape are a core topic in cancer immunology research. Cancer cells can escape T cell-mediated cellular cytotoxicity by exploiting the inhibitory programmed cell-death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1, CD274) immune checkpoint. Studying the PD-L1 regulatory pattern of tumor cells will help elucidate the molecular mechanisms of tumor immune evasion and improve cancer treatment. Recent studies have found that tumor cells regulate PD-L1 at the transcriptional, post-transcriptional, and post-translational levels and influence the anti-tumor immune response by regulating PD-L1. In this review, we focus on the regulation of PD-L1 in cancer cells and summarize the underlying mechanisms.

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Section: Lncrna and Circrnamentioning

confidence: 99%

Current insight into the regulation of PD-L1 in cancer

Liu

et al. 2022

Exp Hematol Oncol

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“…Another mechanism through which hybrid E/M cancer cells induce immune evasion is related to the production of soluble factors. In particular, it has been reported that hybrid E/M cells upregulate the production of immunosuppressive mediators such as TGFβ, IL-8, IL-10, CSF1 (M-CSF), and CCL18 (Taki et al, 2018;Y. Guo, Xie, and Luo 2022) (Figure 4).…”

Section: Immunosuppressive Traits Of Hybrid E/m States and Immune Pla...mentioning

confidence: 99%

“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes

Canciello

Cerveró-Varona²,

Peserico³

et al. 2022

Front. Cell Dev. Biol.

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Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather than fully M cells play key roles in most of physiological and pathological processes involving EMT. To this regard, the onset of hybrid E/M state coincides with the highest stemness gene expression and is involved in differentiation of either normal and cancer stem cells. Moreover, hybrid E/M cells are responsible for wound healing and create a favorable immunosuppressive environment for tissue regeneration. Nevertheless, hybrid state is responsible of metastatic process and of the increasing of survival, apoptosis and therapy resistance in cancer cells. The present review aims to describe the main features and the emerging concepts regulating EMP and the formation of E/M hybrid intermediates by describing differences and similarities between cancer and normal hybrid stem cells. In particular, the comprehension of hybrid E/M cells biology will surely advance our understanding of their features and how they could be exploited to improve tissue regeneration and repair.

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“…miRNAs are a group of non-coding RNA molecules with a length of 19–25 nucleotides that participate in the regulation of gene expression after transcription by targeting the 3untranslated region of the target mRNA sequence and inhibiting mRNA levels ( Navabi et al, 2022 ). lncRNAs are a class of single-stranded RNA molecules with more than 200 nucleotides that are important in molecular networks ( Guo et al, 2022 ). CircRNAs are a class of non-coding RNAs with high stability and significant clinical relevance ( Long et al, 2022 ).…”

Section: The Role Of Extracellular Vesicles-derived From Neurons/neur...mentioning

confidence: 99%

The Emerging Role of Extracellular Vesicle Derived From Neurons/Neurogliocytes in Central Nervous System Diseases: Novel Insights Into Ischemic Stroke

Kang

Xin

et al. 2022

Front. Pharmacol.

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Neurons and neurogliocytes (oligodendrocytes, astrocytes, and microglia) are essential for maintaining homeostasis of the microenvironment in the central nervous system (CNS). These cells have been shown to support cell-cell communication via multiple mechanisms, most recently by the release of extracellular vesicles (EVs). Since EVs carry a variety of cargoes of nucleic acids, lipids, and proteins and mediate intercellular communication, they have been the hotspot of diagnosis and treatment. The mechanisms underlying CNS disorders include angiogenesis, autophagy, apoptosis, cell death, and inflammation, and cell-EVs have been revealed to be involved in these pathological processes. Ischemic stroke is one of the most common causes of death and disability worldwide. It results in serious neurological and physical dysfunction and even leads to heavy economic and social burdens. Although a large number of researchers have reported that EVs derived from these cells play a vital role in regulating multiple pathological mechanisms in ischemic stroke, the specific interactional relationships and mechanisms between specific cell-EVs and stroke treatment have not been clearly described. This review aims to summarize the therapeutic effects and mechanisms of action of specific cell-EVs on ischemia. Additionally, this study emphasizes that these EVs are involved in stroke treatment by inhibiting and activating various signaling pathways such as ncRNAs, TGF-β1, and NF-κB.

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The Role of Long Non-Coding RNAs in the Tumor Immune Microenvironment

Cited by 20 publications

References 268 publications

Current insight into the regulation of PD-L1 in cancer

Current insight into the regulation of PD-L1 in cancer

“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes

The Emerging Role of Extracellular Vesicle Derived From Neurons/Neurogliocytes in Central Nervous System Diseases: Novel Insights Into Ischemic Stroke

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