The role of long noncoding RNAs in malaria parasites

Thompson, Trevor A.; Chahine, Zeinab; Roch, Karine G. Le

doi:10.1016/j.pt.2023.03.016

Cited by 8 publications

(9 citation statements)

References 114 publications

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“…Two lncRNAs transcribed from the telomere-associated repetitive elements ( TARE ), TARE-3-lncRNA and TARE-6-lncRNA , are able to influence the intra-erythrocytic developmental cycle of Plasmodium. Due to the enrichment of binding sites for various transcription factors, it is therefore postulated that TARE-lncRNAs function by regulating neighboring genes [ 172 , 173 , 174 ]. Another class of var gen-specific lncRNAs can be incorporated into chromatin, and play a key role in the activation of var gene, which is able to encode variable antigens and enhance the virulence of P. falciparum .…”

Section: Lncrnas In Parasitic Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

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Zoonoses are diseases and infections naturally transmitted between humans and vertebrate animals. They form the dominant group of diseases among emerging infectious diseases and represent critical threats to global health security. This dilemma is largely attributed to our insufficient knowledge of the pathogenesis regarding zoonotic spillover. Long non-coding RNAs (lncRNAs) are transcripts with limited coding capacity. Recent technological advancements have enabled the identification of numerous lncRNAs in humans, animals, and even pathogens. An increasing body of literature suggests that lncRNAs function as key regulators in zoonotic infection. They regulate immune-related epigenetic, transcriptional, and post-transcriptional events across a broad range of organisms. In this review, we discuss the recent research progress on the roles of lncRNAs in zoonoses. We address the classification and regulatory mechanisms of lncRNAs in the interaction between host and zoonotic pathogens. Additionally, we explore the surprising function of pathogen-derived lncRNAs in mediating the pathogenicity and life cycle of zoonotic bacteria, viruses, and parasites. Understanding how these lncRNAs influence the zoonotic pathogenesis will provide important therapeutic insights to the prevention and control of zoonoses.

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Section: Lncrnas In Parasitic Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

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“…Accumulated evidence indicates that lncRNAs act as transcriptional regulators in P . falciparum , participating in the regulation of parasite genes (Thompson et al, 2023) and critical events associated with virulence throughout the multistage life cycle (Lodde et al, 2022). Similar to other eukaryotes, lncRNAs in Plasmodium also contribute to gene expression in the host and host– Plasmodium interaction.…”

Section: Lncrnas In Malariamentioning

confidence: 99%

“…falciparum exhibit potential binding sites for human miRNAs. This implies that these circular lncRNAs have the capacity to impact host miRNAs and influence the expression of parasite VSA genes during infection (Kataria et al, 2022; Lodde et al, 2022; Thompson et al, 2023). These findings shed light on the potential interaction between exosomal parasite lncRNAs and host miRNAs, thus influencing the expression of both parasite and host genes.…”

Section: Lncrnas In Malariamentioning

confidence: 99%

“…LncRNAs possess a key function in modulating gene expression at various levels, including transcription, posttranscription, RNA turnover, and protein translation (Jia et al, 2022;Patra et al, 2023). Accumulated evidence indicates that lncRNAs act as transcriptional regulators in P. falciparum, participating in the regulation of parasite genes (Thompson et al, 2023) and critical events associated with virulence throughout the multistage life cycle (Lodde et al, 2022). Similar to other eukaryotes, lncRNAs in Plasmodium also contribute to gene expression in the host and host-Plasmodium interaction.…”

Section: Lncrnas In Malariamentioning

confidence: 99%

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Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

et al. 2023

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Overcoming challenges associated with malaria eradication proves to be a formidable task due to the complicated life cycle exhibited by the malaria parasite and the lack of safe and enduring vaccines against malaria. Investigating the interplay between Plasmodium parasites and their mammalian hosts is crucial for the development of novel vaccines. Long noncoding RNAs (lncRNAs) derived from Plasmodium parasites or host cells have emerged as potential signaling molecules involved in the trafficking of proteins, RNA (mRNAs, miRNAs, and ncRNAs), and DNA. These lncRNAs facilitate the interaction between hosts and parasites, impacting normal physiology or pathology in malaria‐infected individuals. Moreover, they possess the capacity to regulate immune responses and associated signaling pathways, thus potentially influencing chromatin organization, epigenetic modifications, mRNA processing, splicing, and translation. However, the functional role of exosomal lncRNAs in malaria remains poorly understood. This review offers a comprehensive analysis of lncRNA and exosomal lncRNA profiles during malaria infection. It presents an overview of recent progress in elucidating the involvement of exosomal lncRNAs in host–parasite interactions. Additionally, potential exosomal lncRNAs linked to the domains of innate and adaptive immunity in the context of malaria are proposed. These findings may contribute to the discovery of new diagnostic and therapeutic strategies for malaria. Furthermore, the need for additional research was highlighted that aimed to elucidate the mechanisms underlying lncRNA transportation into host cells and their targeting of specific genes to regulate the host's immune response. This knowledge gap presents an opportunity for future investigations, offering innovative approaches to enhance malarial control.This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule‐RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease

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“…In many species, lncRNAs have been found to play critical roles in regulating development and reproduction [ 16 ], including myoblast and cardiovascular differentiation [ 17 , 18 ], sex determination [ 19 ], gonadogenesis [ 20 ], sex hormone response [ 21 ], meiosis [ 22 ] and spermatogenesis [ 23 ]. In parasites, lncRNAs have been recognized as crucial regulators in development, sex differentiation and the host-parasite interaction according to the studies on malaria parasites [ 24 , 25 ] and Trypanosoma brucei [ 26 ]. Until recently, the lncRNAs in schistosomes have been identified from the genome and RNA-seq data, revealing over 10,000 lncRNAs [ 27 ], which is almost identical to the number of the protein-coding RNAs.…”

Section: Introductionmentioning

confidence: 99%

Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum

Cheng,

You,

Wang

et al. 2024

PLoS Pathog

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Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts. The regulation of the parasite’s developmental processes relies on both coding RNAs and non-coding RNAs. However, the roles of non-coding RNAs, including long non-coding RNAs (lncRNAs) in schistosomes remain largely unexplored. Here we conduct advanced RNA sequencing on male and female S. japonicum during their pairing and reproductive development, resulting in the identification of nearly 8,000 lncRNAs. This extensive dataset enables us to construct a comprehensive co-expression network of lncRNAs and mRNAs, shedding light on their interactions during the crucial reproductive stages within the mammalian host. Importantly, we have also revealed a specific lncRNA, LNC3385, which appears to play a critical role in the survival and reproduction of the parasite. These findings not only enhance our understanding of the dynamic nature of lncRNAs during the reproductive phase of schistosomes but also highlight LNC3385 as a potential therapeutic target for combating schistosomiasis.

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The role of long noncoding RNAs in malaria parasites

Cited by 8 publications

References 114 publications

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum

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