The Role of Low Molecular Weight Heparin in Women With Hereditary Thrombophilia for Good Perinatal Outcome

Abstract

SUMMARY -Th e aim of the study was to establish the importance of low molecular weight heparin (LMWH) treatment for good pregnancy outcome in patients with hereditary thrombophilia. Th is retrospective study included 70 patients with inherited thrombophilia who gave birth at Zagreb University Hospital Center in the period from January 2014 to January 2015. Fifty-seven women were treated and 13 women were not treated with LMWH. Perinatal outcome was signifi cantly better in women with hereditary thrombophilia who were treated with heparin during pregnancy as compared with women without LMWH (p=0.006). Regardless of heparin therapy, patients with hereditary thrombophilia alone had a signifi cantly better perinatal outcome as compared with women who, along with hereditary thrombophilia, had a history of habitual abortions (p=0.035) or intrauterine fetal death (p=0.033). Women treated with heparin had better perinatal outcome if they were without a history of recurrent or non-recurrent fetal loss (p=0.088). In the group without LMWH, perinatal outcome was signifi cantly better in women with no history of habitual abortions as compared with women with recurrent miscarriages (p=0.047). Administration of LMWH is justifi ed in women with hereditary thrombophilia and a history of adverse perinatal outcome.

Deep Septic Pelvic Thrombophlebitis – a Life-Threatening Condition in Postpartum Period

“…To exclude other causes of thrombophilia (besides pregnancy as a hypercoagulable state) in spite of negative history data, our patient was referred to hematologist. In case of future pregnancies, prophylactic dosage of LMWH should be considered ( 8 ).…”

Low molecular weight heparin and pregnancy outcomes in women with inherited thrombophilia: A systematic review and meta‐analysis

“…On the basis of a review of the full texts of 133 studies, 111 studies were excluded, mainly because they were reviews, had no controls, or included individuals without inherited thrombophilia. Finally, 22 studies, including 12 cohort studies and 10 randomized controlled trials, were identified as eligible and included in the present systematic review and meta-analysis 13,17,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (Figure 1). No eligible gray literature was found.…”

The prognostic role of thrombophilia in the treatment of infertility

“…Azoknál a terhes nőknél, akiknek visszatérő vetélés volt a kórelőzményében, és alacsony molekulasúlyú heparint (LMWH) kaptak, jobbak voltak a perinatalis következ-mények. Az LMWH alkalmazása indokolt az örökletes thrombophiliában szenvedő nők esetében [26,27,28].…”