The Role of &lt;b&gt;&lt;i&gt;Faecalibacterium, Roseburia&lt;/i&gt;&lt;/b&gt;, and Butyrate in Inflammatory Bowel Disease

Faden, Howard

doi:10.1159/000522247

Cited by 22 publications

(20 citation statements)

References 19 publications

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“…Moreover, we found that the levels of lipid, Alb and Hb were positively correlated with the abundances of SCFA-producing probiotics which enriched in HCs, such as Lachnospiraceae_ND3007_group , Faecalibacterium , Roseburia , Dorea and Butyricicoccus ( Figure 3 ), indicating the enrichment of probiotics were related to the healthy physiological state of the host. Faecalibacterium and Roseburia are major producers of butyrate, which decreased Mtb -induced inflammation as well as insulin resistance ( Jo et al., 2021 ; Faden, 2022 ). Meanwhile, the mentioned indexes were negatively correlated with the abundances of Lactobacillus , Erysipelatoclostridium and Sellimonas , which enriched in PTB patients ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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IntroductionRecent studies have provided insights into the important contribution of gut microbiota in the development of Pulmonary Tuberculosis (PTB). As a chronic consumptive infectious disease, PTB involves many pathological characteristics. At present, research on intestinal flora and clinical pathological Index of PTB is still rare.MethodsWe performed a cross-sectional study in 63 healthy controls (HCs) and 69 patients with untreated active PTB to assess the differences in their microbiota in feces via 16S rRNA gene sequencing.ResultsSignificant alteration of microbial taxonomic and functional capacity was observed in PTB as compared to the HCs. The results showed that the alpha diversity indexes of the PTB patients were lower than the HCs (P<0.05). Beta diversity showed differences between the two groups (P<0.05). At the genus level, the relative abundance of Bacteroides, Parabacteroides and Veillonella increased, while Faecalibacterium, Bifidobacterium, Agathobacter and CAG-352 decreased significantly in the PTB group, when compared with the HCs. The six combined genera, including Lactobacillus, Faecalibacterium, Roseburia, Dorea, Monnoglobus and [Eubacterium]_ventriosum_group might be a set of diagnostic biomarkers for PTB (AUC=0.90). Besides, the predicted bacterial functional pathway had a significant difference between the two groups (P<0.05), which was mainly related to the nutrient metabolism pathway. Significant alterations in the biochemical index were associated with changes in the relative abundance of specific bacteria, the short chain fatty acid (SCFA)-producing bacteria enriched in HCs had a positively correlated with most of the biochemical indexes.DiscussionOur study indicated that the gut microbiota in PTB patients was significantly different from HCs as characterized by the composition and metabolic pathway, which related to the change of biochemical indexes in the PTB group. It was hypothesized that the abovementioned changes in the gut microbiota could exert an impact on the clinical characteristics of PTB through the regulation of the nutrient utilization pathway of the host by way of the gut-lung axis.

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Section: Discussionmentioning

confidence: 99%

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…80 Other microorganisms have the ability to produce butyrate, which can not only alleviate inflammation but also encourage the production of hormones for a healthy metabolism. 81 According to the decrease in the abundance of Firmicutes in group M, it was indicated that acetic acid destroyed the oral epithelial barrier, damaged the beneficial metabolism of microbes, and led to an imbalance in oral microecology. After being treated with LTE, the relative abundance of Firmicutes and Actinobacteria increased significantly, while that of Proteobacteria decreased (Fig.…”

Section: Resultsmentioning

confidence: 99%

A local dark tea – Liubao tea – extract exhibits remarkable performance in oral tissue regeneration, inflammation relief and oral microbiota reconstruction

Zhou

Bao

Ma³

et al. 2023

Food Funct.

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“…It has been reported that Algiphilus can produce succinic acid and a small amount of acetic and propionic acids, and that succinic acid can activate intestinal gluconeogenesis, imparting beneficial effects on blood sugar metabolism and obesity management [ 53 ]. The genus Faecalibacterium is one of the most important bacteria in the human gut flora and one of the important producers of butyric acid, which has anti-inflammatory and protective effects on the digestive system from intestinal pathogens, particularly effective in obese patients [ 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Simulated Digestion and Fermentation In Vitro by Obese Human Gut Microbiota of Sulforaphane from Broccoli Seeds

Sun

Tang

Hao

et al. 2022

Foods

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Background: sulforaphane is a kind of isothiocyanate, which is obtained by hydrolysis of glucosinolate by the unique myrosinase in plants. It has been proved to prevent the occurrence of many chronic diseases, such as obesity, diabetes and cancer. Objective: The impact of SFN on obese human gut flora, however, has not been established. Methods: In this research, SFN was isolated from broccoli seeds and then refined to achieve 95% purity. Next, an investigation was conducted into the digestion and fermentation processes of SFN. Results: The stability of the SFN in simulated saliva, gastric fluid, and intestinal juice provides evidence that it can reach the gut and be available for utilization by gut microflora. In vitro fermentation of SFN by gut microbes in obese patients results in alteration in constitution of microbiota and production of short chain fatty acids. As the result of SFN ingestion by human gut bacteria, the content of butyric and valeric acids increased 1.21- and 1.46-fold, respectively. In obese human guts, the relative abundances of the beneficial genera including Lactobacillus, Weissella, Leuconosto, Algiphilus and Faecalibacterium significantly increased, whilst the detrimental genera, such as Escherichia-Shigella, Klebsiella, Clostridium_sensu_stricto_1, Sutterella, Megamonas and Proteus drastically declined. Conclusion: Taken together, these findings demonstrate that SFN can be used as a nutraceutical ingredient for obese patients and for improving human health.

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The Role of <b><i>Faecalibacterium, Roseburia</i></b>, and Butyrate in Inflammatory Bowel Disease

Abstract: Faecalibacterium and Roseburia are major producers of butyrate in the intestine. A reduced abundance of the organisms and a concurrent reduction in butyrate levels are associated with inflammatory bowel disease.

Cited by 22 publications

References 19 publications

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

A local dark tea – Liubao tea – extract exhibits remarkable performance in oral tissue regeneration, inflammation relief and oral microbiota reconstruction

Simulated Digestion and Fermentation In Vitro by Obese Human Gut Microbiota of Sulforaphane from Broccoli Seeds

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