The Role of Macrophage-Derived Extracellular Vesicles in Gastrointestinal Cancers

Renovato-Martins, Mariana; Gomes, Aline Casimiro; Amorim, Carolinne Souza; Moraes, João Alfredo

doi:10.36255/exon-publications-gastrointestinal-cancers-extracellular-vescicles

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“…Propofol promoted the release of EV subtypes from tumor-associated macrophages, which could inhibit the invasion and growth of hepatocellular carcinoma cells via the transport of a tumor-suppressive miRNA, miR-142-3p [32]. Meanwhile, interactions between EVs and tumor-associated protective as well as oncogenic macrophages have been more extensively studied and are already being discussed and explored as therapeutic targets [39].…”

Section: Discussionmentioning

confidence: 99%

Influence of the Anesthetic Technique on Circulating Extracellular Vesicles in Bladder Cancer Patients Undergoing Radical Cystectomy: A Prospective, Randomized Trial

Gluth,

Ochsenfarth,

Pham

et al. 2023

Cells

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Anesthetics have been shown to alter tumor progression and seem to influence surgical cancer outcome. Circulating extracellular vesicles as mediators of intercellular communication are involved in cancer progression and may be influenced by anesthetics. In this prospective, randomized study, effects of anesthetics on extracellular vesicles and associated micro-RNAs in bladder cancer patients undergoing radical cystectomy were tested. Extracellular vesicles from 51 patients at four perioperative time points receiving Propofol or Sevoflurane were extracted with polymer-based methods and quantified with a nanoparticle-tracking analysis. Vesicle-associated micro-RNAs were analyzed with a real-time polymerase chain reaction using array cards and single assays for tumor-associated miR-21-5p, miR-15a-5p, miR-17-5p and miR-451a. Plasma extracellular vesicle concentration (suture: fold change (fc) in Propofol at 4.1 ± 3.9 vs. Sevoflurane at 0.8 ± 0.5; p = 0.003) and associated miRNAs increased significantly (+30% post induction, +9% 30 Min surgery) in the Propofol group. Tumor-associated miRNAs increased during surgery in both groups (fc in miR-21-5p: 24.3 ± 10.2, p = 0.029; fc in miR-15a-5p: 9.7 ± 3.8, p = 0.027; fc in miR-17-5p: 5.4 ± 1.7, p = 0.014), whereas antitumor miR-451a increased in the Propofol group only (fc: 2.5 ± 0.6 vs. 1.0 ± 0.2; p = 0.022). Anesthetics influence extracellular vesicles and associated micro-RNAs of bladder cancer patients during surgery. Increased expression of antitumor micro-RNA may be an explanatory approach for decreased tumor cell viability after Propofol.

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Section: Discussionmentioning

confidence: 99%