The role of macrophages in skin homeostasis

Yanez, Diana A.; Lacher, Richard K.; Vidyarthi, Aurobind; Colegio, Oscar R.

doi:10.1007/s00424-017-1953-7

Cited by 86 publications

(61 citation statements)

References 79 publications

(121 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Macrophages are present in almost every tissue or organ system including the barriers system comprising of respiratory tract (pulmonary alveolar and interstitial macrophages), skin, gastrointestinal tract (GIT), and reproductive tract [82][83][84][85][86][87][88][89][90][91]. Thus their presence in the every organ system along with the mucosal sites serving as potential sites for the entry of pathogens, toxins, allergens and xenobiotics makes them first line of defense.…”

Section: Role Of Monocytes and Macrophages In Host Defensementioning

confidence: 99%

Macrophages: The Potent Immunoregulatory Innate Immune Cells

Kumar¹

2020

Macrophage Activation - Biology and Disease

View full text Add to dashboard Cite

Macrophages are ubiquitously present innate immune cells in humans and animals belonging to both invertebrates and vertebrates. These cells were first recognized by Elia Metchnikoff in 1882 in the larvae of starfish upon insertion of thorns of tangerine tree and later in Daphnia magna or common water flea infected with fungal spores as cells responsible for the process of phagocytosis of foreign particles. Elia Metchnikoff received the Noble prize (Physiology and Medicine) for his discovery and describing the process of phagocytosis in 1908. More than 130 years have passed and different subtypes and roles of macrophages as innate immune cells have been established by the researchers. In addition to their immunoregulatory role in immune homeostasis and pathogenic infection, they also play a crucial role in the pathogenesis of sterile inflammatory conditions including autoimmunity, obesity, and cancer. The present chapter describes the immunoregulatory role of macrophages in the homeostasis and inflammatory diseases varying from autoimmunity to metabolic diseases including obesity.

show abstract

Section: Role Of Monocytes and Macrophages In Host Defensementioning

confidence: 99%

Macrophages: The Potent Immunoregulatory Innate Immune Cells

Kumar¹

2020

Macrophage Activation - Biology and Disease

View full text Add to dashboard Cite

show abstract

“…During the proliferation phase, Mo/MΦ help to downregulate inflammation, promote angiogenesis, formation of granulation tissue, and deposition of collagen. Later, Mo/MΦ also promote wound closure and collagen remodeling . In short, Mo/MΦ play a vital role in all stages of healing.…”

Section: Introductionmentioning

confidence: 99%

Proliferation of Ly6C+ monocytes/macrophages contributes to their accumulation in mouse skin wounds

Pang

Urao

Koh

2019

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Monocytes and macrophages (Mo/MΦ) play critical roles in all phases of skin wound healing. The majority of these cells are thought to be recruited from blood Mo; however, the role local proliferation of Mo/MΦ in the wound has not been defined. Therefore, we tested the hypothesis that local proliferation of Mo and/or MΦ contributes to their accumulation during wound healing. Male C57Bl/6 mice (N = 4–9/group) were subjected to excisional skin wounding. Proliferating Mo/MΦ (F4/80+Ki67+) were observed in wound cryosections, peaking on day 5 post‐wounding. Cell cycle analysis on cells isolated from skin tissue revealed that wounding increased both the number and percentage of inflammatory Ly6C+F4/80lo/− Mo/MΦ in the S/G2/M phases, peaking on day 6 post‐wounding. In contrast, more mature Ly6C‐F4/80+ cells were found predominantly in the G0 phase with less than 1% cells in S/G2/M phase following injury. In peripheral blood, Mo were very rarely found in the S/G2/M phase, suggesting that the wound environment triggered the Ly6C+F4/80lo/− Mo proliferative response. Furthermore, injury induced several potential regulators of proliferation in wounds, including IL‐1β and IL‐6, and wound Mo/MΦ expressed surface receptors for these cytokines. However, wound Mo/MΦ proliferation was not altered in IL‐1R1 knockout (KO) or IL‐6 KO mice. In summary, our findings indicate that proliferation contributes to Mo/MΦ accumulation in wounds and, contrary to findings in other pathophysiologic conditions, Ly6C+/F4/80lo/− Mo/MΦ proliferate during skin wound healing whereas mature Ly6C−F4/80+ MΦ do not.

show abstract

“…23,29,30 Lastly, in the skin, macrophages might be present as Langerhans cells or histiocytes, which primarily function in phagocytosis as well as antigen capture, processing, and presentation. 13,[21][22][23][31][32][33]…”

Section: Introductionmentioning

confidence: 99%

<p>Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases</p>

Sousa¹,

Vasconcelos²,

Quaresma³

2019

IDR

View full text Add to dashboard Cite

Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of macrophage phenotypic heterogeneity has been investigated since the 1980s, and more recent studies have identified a diverse spectrum of phenotypic subpopulations. Several types of macrophages play a central role in the response to infectious agents and, along with other components of the immune system, determine the clinical outcome of major infectious diseases. Here, we review the functions of various macrophage phenotypic subpopulations, the concept of macrophage polarization, and the influence of these cells on the evolution of infections. In addition, we emphasize their role in the immune response in vivo and in situ, as well as the molecular effectors and signaling mechanisms used by these cells. Furthermore, we highlight the mechanisms of immune evasion triggered by infectious agents to counter the actions of macrophages and their consequences. Our aim here is to provide an overview of the role of macrophages in the pathogenesis of critical transmissible diseases and discuss how elucidation of this relationship could enhance our understanding of the host–pathogen association in organ-specific immune responses.

show abstract

The role of macrophages in skin homeostasis

Cited by 86 publications

References 79 publications

Macrophages: The Potent Immunoregulatory Innate Immune Cells

Macrophages: The Potent Immunoregulatory Innate Immune Cells

Proliferation of Ly6C+ monocytes/macrophages contributes to their accumulation in mouse skin wounds

<p>Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases</p>

Contact Info

Product

Resources

About