The role of magnetic resonance imaging techniques in evaluation and management of the idiopathic inflammatory myopathies

Day, Jessica; Patel, Sandy; Limaye, Vidya

doi:10.1016/j.semarthrit.2016.11.001

Cited by 77 publications

(69 citation statements)

References 61 publications

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“…MRI can also guide muscle biopsy location for increased yield [4]. Day et al reviewed the use of MRI in IIMs in 2016 [9]. MRI imaging, particularly fat suppressed images, can be useful in identifying muscle regions with active inflammation versus regions of fat infiltration.…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…MRI imaging, particularly fat suppressed images, can be useful in identifying muscle regions with active inflammation versus regions of fat infiltration. Appropriately, the review noted that many etiologies also associated with elevated CK and may cause inflammatory changes on MRI of muscle tissue; thus, muscle biopsy remains the gold standard in diagnosis [9]. However, MRI can be used to increase the yield of muscle biopsy by directing the biopsy to be performed in a location with active inflammation versus region(s) with chronic changes or fat infiltration, which may have non-diagnostic histopathology [9].…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…Appropriately, the review noted that many etiologies also associated with elevated CK and may cause inflammatory changes on MRI of muscle tissue; thus, muscle biopsy remains the gold standard in diagnosis [9]. However, MRI can be used to increase the yield of muscle biopsy by directing the biopsy to be performed in a location with active inflammation versus region(s) with chronic changes or fat infiltration, which may have non-diagnostic histopathology [9]. The review also noted that MRI had a sensitivity of 89–100% when using short-T1 inversion recovery (STIR) images and the specificity of MRI imaging was 80–88% [9].…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…However, MRI can be used to increase the yield of muscle biopsy by directing the biopsy to be performed in a location with active inflammation versus region(s) with chronic changes or fat infiltration, which may have non-diagnostic histopathology [9]. The review also noted that MRI had a sensitivity of 89–100% when using short-T1 inversion recovery (STIR) images and the specificity of MRI imaging was 80–88% [9]. Although there is no clear consensus on using MRI imaging for monitoring disease activity, MRI may be considered as a tool for differentiating active versus chronic disease activity [9].…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…The review also noted that MRI had a sensitivity of 89–100% when using short-T1 inversion recovery (STIR) images and the specificity of MRI imaging was 80–88% [9]. Although there is no clear consensus on using MRI imaging for monitoring disease activity, MRI may be considered as a tool for differentiating active versus chronic disease activity [9]. …”

Section: Clinical Presentationsmentioning

confidence: 99%

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Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis

Mandel

Malemud

Askari

2017

IJMS

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Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune muscle diseases with significant morbidity and mortality. This review details and updates the pathogenesis and emerging importance of myositis-specific antibodies in the development of IIMs. An increase in the understanding of how these myositis-specific antibodies play a role in IIMs has led to the further categorization of IIMs from the traditional polymyositis versus dermatomyositis, to additional subcategories of IIMs such as necrotizing autoimmune myositis (NAM). The diagnosis of IIMs, including manual muscle testing, laboratory studies, and non-invasive imaging have become important in classifying IIM subtypes and for identifying disease severity. Treatment has evolved from an era where glucocorticoid therapy was the only option to a time now that includes traditional steroid-sparing agents along with immunoglobulin therapy and biologics, such as rituximab.

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Section: Clinical Presentationsmentioning

confidence: 99%

Section: Clinical Presentationsmentioning

confidence: 99%

Section: Clinical Presentationsmentioning

confidence: 99%

Section: Clinical Presentationsmentioning

confidence: 99%

Section: Clinical Presentationsmentioning

confidence: 99%

See 3 more Smart Citations

Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis

Mandel

Malemud

Askari

2017

IJMS

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A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T_2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI

Gollifer

Bray

Kruezi

et al. 2023

Magnetic Resonance in Med

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Short-inversion-time inversion-recovery MRI is used widely for imaging bone and soft-tissue inflammation in rheumatic inflammatory diseases, but there is no widely available quantitative equivalent of this sequence. This limits our ability to objectively assess inflammation and distinguish it from other processes. To address this, we investigate the use of the widely available Dixon turbo spin echo (TSE Dixon) sequence as a practical approach to simultaneous water-specific T 2 (T 2water ) and fat fraction (FF) measurement. Methods:We use a series of TSE Dixon acquisitions with varying effective TEs (TE eff ) to quantify T 2water and FF. The validity of this approach is assessed in a series of phantom and in vivo experiments, with reference values provided by Carr-Purcell-Meiboom-Gill acquisitions, MRS, and phantoms. The effect of inflammation on parameter values is evaluated in patients with spondyloarthritis.

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Radiographic patterns of muscle involvement in the idiopathic inflammatory myopathies

et al. 2019

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Introduction This study assesses the burden, distribution, and evolution of muscle inflammation and damage on MRI among subtypes of idiopathic inflammatory myopathy (IIM). Methods Musculoskeletal MRIs performed in 66 patients with IIM and 10 patients with non‐IIM between 2009 and 2016 were retrospectively graded for muscle edema, fatty replacement (FR), and atrophy. Results Immune‐mediated necrotizing myopathy (IMNM) patients had severe and extensive lower limb muscle edema, FR, and atrophy. The pelvic muscles and adductors were significantly more affected than in patients with dermatomyositis and polymyositis. Inclusion body myositis (IBM) was characterized by marked anterior thigh involvement, which stabilized or progressed at follow‐up imaging. Atrophy and FR grades improved over time in some non‐IBM IIM patients. Discussion Patients with IMNM and IBM have characteristic patterns of muscle MRI abnormalities that may allow them to be differentiated radiologically from other IIM subtypes. Muscle damage in non‐IBM IIM may be reversible.

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The role of magnetic resonance imaging techniques in evaluation and management of the idiopathic inflammatory myopathies

Cited by 77 publications

References 61 publications

Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis

Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis

A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T_2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI

Radiographic patterns of muscle involvement in the idiopathic inflammatory myopathies

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The role of magnetic resonance imaging techniques in evaluation and management of the idiopathic inflammatory myopathies

Cited by 77 publications

References 61 publications

Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis

Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis

A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI

Radiographic patterns of muscle involvement in the idiopathic inflammatory myopathies

Contact Info

Product

Resources

About

A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T_2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI