The role of major virulence factors of AIEC involved in inflammatory bowl disease—a mini-review

Yang, Yuqian; Liao, Yuexia; Ma, Yan; Gong, Weijuan; Zhu, Guoqiang

doi:10.1007/s00253-017-8507-y

Cited by 16 publications

(12 citation statements)

References 50 publications

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“…Mechanisms that alter the mucosal composition or increase bacterial adhesion, secretion of toxins, or competition with the host for resources could contribute to IBD and IBS pathogenesis. So far, studies of virulence mechanisms in the context of GI diseases have focused on specific groups of bacteria such as adherent-invasive E. coli (31) and microbial proteases (32). By exploring the pathogenic potential of the gut microbiota community in IBD and IBS, we were able to identify other potential targets such as Mu-toxin in patients with UC.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

et al. 2018

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Changes in the gut microbiota have been associated with two of the most common gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here, we performed a case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population. Despite substantial overlap between the gut microbiome of patients with IBD and IBS compared with control individuals, we were able to use gut microbiota composition differences to distinguish patients with IBD from those with IBS. By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions, antibiotic resistance, and virulence factor analyses, we identified key bacterial species that may be involved in two common gastrointestinal diseases.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

et al. 2018

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“…AIEC has been postulated as a cause of inflammatory bowel disease. However, at present, there is no consensus on this issue (Palmela et al, 2018 ; Perna et al, 2020 ), and the putative virulence factors described as involved in AIEC pathogenesis are common to strains isolated from extraintestinal infections (Martinez-Medina et al, 2009 ; Yang et al, 2017 ). Furthermore, although DAEC is a recognized enteric pathogen and the presence of genes encoding afimbrial adhesins are occasionally used for screening this pathotype, these genes are also present in other intestinal and extraintestinal pathogenic E. coli as well as in commensal strains, limiting their usefulness in defining the DAEC pathotype (Croxen et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Diversity of Hybrid- and Hetero-Pathogenic Escherichia coli and Their Potential Implication in More Severe Diseases

Santos¹,

Santos²,

Silva³

et al. 2020

Front. Cell. Infect. Microbiol.

112

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Although extraintestinal pathogenic Escherichia coli (ExPEC) are designated by their isolation site and grouped based on the type of host and the disease they cause, most diarrheagenic E. coli (DEC) are subdivided into several pathotypes based on the presence of specific virulence traits directly related to disease development. This scenario of a well-categorized E. coli collapsed after the German outbreak of 2011, caused by one strain bearing the virulence factors of two different DEC pathotypes (enteroaggregative E. coli and Shiga toxin-producing E. coli ). Since the outbreak, many studies have shown that this phenomenon is more frequent than previously realized. Therefore, the terms hybrid- and hetero-pathogenic E. coli have been coined to describe new combinations of virulence factors among the classic E. coli pathotypes. In this review, we provide an overview of these classifications and highlight the E. coli genomic plasticity that results in some mixed E. coli pathotypes displaying novel pathogenic strategies, which lead to a new symptomatology related to E. coli diseases. In addition, as the capacity for genome interrogation has grown in the last few years, it is clear that genes encoding some virulence factors, such as Shiga toxin, are found among different E. coli pathotypes to which they have not traditionally been associated, perhaps foreshowing their emergence in new and severe outbreaks caused by such hybrid strains. Therefore, further studies regarding hetero-pathogenic and hybrid-pathogenic E. coli isolates are necessary to better understand and control the spread of these pathogens.

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“…The virulence factors of the AIEC strain (Table ) confer the characteristic of adhering, invading, replicating in macrophages, and surviving in host cells, causing dysfunctions in the gastric barrier and a marked proinflammatory response in the host, triggering a series of signaling pathways with consequent development of the IBS pathology (Yang, Liao, Ma, Gong, & Zhu, ). There is no difference in the virulence genes of E. coli strains isolated from IBS patients and healthy people (Dogan et al, ).…”

Section: Ecoli Aiecmentioning

confidence: 99%

Adherent‐invasive Escherichia coli (AIEC): Cause or consequence of inflammation, dysbiosis, and rupture of cellular joints in patients with IBD?

Perna

Hay

Contieri

et al. 2020

Journal Cellular Physiology

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There are many factors contributing to the development of gastrointestinal diseases, grouped into genetic, environmental, and lifestyle factors. In recent years attention has fallen on pathogens; in particular, Bacteroides fragilis, Fusobacterium nucleatum, Escherichia coli (E. coli) and Helicobacter pylori have been studied. Several points remain to be clarified, and above all, as regards the adherent‐invasive E. coli strains of E. coli, one wonders if they are a cause or a consequence of the disease. In this review, we have tried to clarify some points by examining a series of recent publications regarding the involvement of the bacterium in the pathology, even if other studies are necessary.

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The role of major virulence factors of AIEC involved in inflammatory bowl disease—a mini-review

Cited by 16 publications

References 50 publications

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

Diversity of Hybrid- and Hetero-Pathogenic Escherichia coli and Their Potential Implication in More Severe Diseases

Adherent‐invasive Escherichia coli (AIEC): Cause or consequence of inflammation, dysbiosis, and rupture of cellular joints in patients with IBD?

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