The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media

Darmawan, Anton Budhi; Soesatyo, Marsetyawan Hne; Restuti, Ratna Dwi; Surono, Agus

doi:10.1155/2018/6178159

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that MBL deficiency plays an important role in host defence, especially during the vulnerable period of infancy between 6 and 17 months of age, when maternal antibodies wane and the adaptive immune system is still developing 18 . These factors make children susceptible to infection by specific pathogens such as S. pneumoniae -one of the most important pathogens causing respiratory tract infections 20 .…”

Section: Discussionmentioning

confidence: 99%

Respiratory outcomes at five-year follow-up in children with MBL deficiency: a cohort study

Ramphul

Poghosyan

Afzaal

et al. 2021

Preprint

View full text Add to dashboard Cite

Introduction Mannose-binding lectin (MBL) serum protein, is an important molecule of the innate immune system that is involved in antimicrobial recognition and clearing responses. There is no conclusive evidence that MBL deficiency is associated with adverse respiratory consequences. Aim We explored whether there is a difference in clinical, radiological and microbiological characteristics in children with MBL deficiency presenting with troublesome respiratory symptoms (frequent, recurrent, persistent or very severe), as compared to those who are MBL-sufficient. Methods We performed a retrospective study looking at MBL measurements in children over a period of 10 years in a large teaching hospital, with a minimum follow-up period of 5 years from the time of the MBL measurement to the year 2019. Results 32% of children with MBL deficiency and 30% of those with MBL sufficiency had positive microbiology. 23% of children with MBL deficiency and 24% of those with MBL sufficiency had radiological changes on plain radiographs. 28% of children with MBL deficiency and 33% of those with MBL sufficiency had suboptimal vaccine responses to primary immunisations. 67% of the MBL-deficient children had suboptimal vaccine responses to booster immunisations, compared to 40% of the MBL-sufficient group. Conclusion We conclude that there is no difference at five year follow-up in clinical, radiological and microbiological characteristics between children who are MBL-deficient as compared to those who have sufficient levels. These results add to the existing body of literature that shows no statistically significant association between MBL deficiency and susceptibility to recurrent respiratory tract infection in children.

show abstract

Section: Discussionmentioning

confidence: 99%

Respiratory outcomes at five-year follow-up in children with MBL deficiency: a cohort study

Ramphul

Poghosyan

Afzaal

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Staphylococcus aureus and Pseudomonas aeruginosa in Tubotympanic Chronic Suppurative Otitis Media Patients in Purwokerto, Indonesia

et al. 2020

View full text Add to dashboard Cite

BACKGROUND: Chronic Suppurative Otitis Media (CSOM) causes hearing impairment and frequently occurred in low-income country where medical care and personal hygiene are poor. Staphylococcus aureus and Pseudomonas aeruginosa are the most common cause of CSOM. We investigated prevalence and antimicrobial susceptibility of S. aureus and P. aeruginosa from tubotympanic CSOM patients in tertiary hospital, Purwokerto, Indonesia in 2016-2017.METHODS: Ear swab specimens were collected from patients with tubotympanic CSOM. S. aureus and P. aeruginosa were isolated and identified by culture, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and molecular tools. Antimicrobial susceptibility testing was performed using the disk diffusion method.RESULTS: Out of ear swabs from 34 patients with tubotympanic CSOM, P. aeruginosa and S. aureus were identified in 35%patients. No Methicillin-resistant S. aureus (MRSA) strain was found from the ear swabs of the patients with tubotympanic CSOM. Bacterial identification using the MALDI-TOF MS was concordantly with culture and molecular tools. All S. aureus isolates showed full susceptibility to cefoxitin and trimethoprim-sulphamethoxazole. Resistance to tetracycline was common with only 64% of S. aureus strains being susceptible. Meanwhile, all P. aeruginosa strains were susceptible to cefepime, cetazidime, meropenem, gentamicin, and tobramycin.CONCLUSION: S. aureus and P. aeruginosa are found in patients with tubotympanic CSOM and still susceptible to different antibiotic agents. MALDI-TOF MS demonstrate rapid, accurate and robust to detect S. aureus and P. aeruginosa.KEYWORDS: Staphylococcus aureus, Pseudomonas aeruginosa, chronic tubotympanic suppurative otitis media

show abstract

The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media

Cited by 2 publications

References 18 publications

Respiratory outcomes at five-year follow-up in children with MBL deficiency: a cohort study

Respiratory outcomes at five-year follow-up in children with MBL deficiency: a cohort study

Staphylococcus aureus and Pseudomonas aeruginosa in Tubotympanic Chronic Suppurative Otitis Media Patients in Purwokerto, Indonesia

Contact Info

Product

Resources

About