The Role of Manual Acupuncture and Morphine Administration on the Modulation of Capsaicin-Induced Edema in Rat Paw. A Blind Controlled Study

Ceccherelli, Francesco; Gagliardi, Giuseppe; Matterazzo, Giovanni; Visentin, Renea; Giron, Giampiero

doi:10.3727/036012996816356951

Cited by 10 publications

(7 citation statements)

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“…Similar results have been reported before in studies where oedema was induced in experimental animals [8,12,14]. However, when considering these results, it must be noted that there also were more dogs with oedema in the treatment group three days after the surgery, even if this difference between groups was not significant.…”

Section: Discussionsupporting

confidence: 89%

“…Acupuncture relieves inflammation by different mechanisms [6-13]; increases blood circulation in the affected area, with subsequent increase of neuropeptides, cytokines and other vasoactive substances [1] as well as reduces oedema [8,12,14]. Acupuncture enhances wound healing accelerators such as fibroblast growth factors (FGF) and platelet-derived growth factors (PDGF) in experimental models [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study

et al. 2010

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BackgroundThe aim of the study was to investigate the effect of acupuncture on wound healing after soft tissue or orthopaedic surgery in dogs.Methods29 dogs were submitted to soft tissue and/or orthopaedic surgeries. Five dogs had two surgical wounds each, so there were totally 34 wounds in the study. All owners received instructions for post operative care as well as antibiotic and pain treatment. The dogs were randomly assigned to treatment or control groups. Treated dogs received one dry needle acupuncture treatment right after surgery and the control group received no such treatment. A veterinary surgeon that was blinded to the treatment, evaluated the wounds at three and seven days after surgery in regard to oedema (scale 0-3), scabs (yes/no), exudate (yes/no), hematoma (yes/no), dermatitis (yes/no), and aspect of the wound (dry/humid).ResultsThere was no significant difference between the treatment and control groups in the variables evaluated three and seven days after surgery. However, oedema reduced significantly in the group treated with acupuncture at seven days compared to three days after surgery, possibly due the fact that there was more oedema in the treatment group at day three (although this difference was nor significant between groups).ConclusionsThe use of a single acupuncture treatment right after surgery in dogs did not appear to have any beneficial effects in surgical wound healing.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study

et al. 2010

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“…Acupuncture could diminish capsaicin-induced oedema in the rat paw, indicating a prominent role for substance P and other neuropeptides. 68 In dogs, the concentrations of substance P were determined in the skin, muscle and subcutis of acupoints and control points, showing an increased release of substance P after acupuncture. 69 On the other hand, an observation in rabbit tooth pulp showed that, after an initial substance P release had already been evoked, electroacupuncture suppressed this release.…”

Section: Neuropeptidesmentioning

confidence: 99%

Anti‐inflammatory actions of acupuncture

Zijlstra

Lange

Huygen

et al. 2003

Mediators of Inflammation

294

191

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Acupuncture has a beneficial effect when treating many diseases and painful conditions, and therefore is thought to be useful as a complementary therapy or to replace generally accepted pharmacological intervention. The attributive effect of acupuncture has been investigated in inflammatory diseases, including asthma, rhinitis, inflammatory bowel disease, rheumatoid arthritis, epicondylitis, complex regional pain syndrome type 1 and vasculitis. Large randomised trials demonstrating the immediate and sustained effect of acupuncture are missing. Mechanisms underlying the ascribed immunosuppressive actions of acupuncture are reviewed in this communication. The acupuncture-controlled release of neuropeptides from nerve endings and subsequent vasodilative and anti-inflammatory effects through calcitonine gene-related peptide is hypothesised. The complex interactions with substance P, the analgesic contribution of beta-endorphin and the balance between cell-specific pro-inflammatory and anti-inflammatory cytokines tumour necrosis factor-alpha and interleukin-10 are discussed.

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“…The anti-inflammatory effects of EPG were evaluated using the carrageenan-induced paw edema test in rats, according to the method of Ceccherelli et al (1996). Briefly, rats were injected subplantarly into the right hind paw with 50 µL of carrageenan suspension (1% in saline).…”

Section: Paw Edema Testsmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Effects of Hydroalcoholic Extract of Leaves of Piptadenia Gonoacantha (Mart.) Macbr. In Experimental Animal Models

Carvalho

Santana²,

Amaro³

et al. 2014

CeN

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This study aimed to evaluate the anti-inflammatory and antinociceptive effects of hydroalcoholic extract of P.gonoacantha leaves (EPG). The toxic effect of the EPG was tested against A.salina in order to determine a secure dose for subsequent assays. The antinociception was evaluated using the acetic acid-induced writhing and hot plate tests in Wistar rats. The anti-inflammatory effect of EPG was evaluated by carrageenan-induced paw edema tests in rats. The bioassay with A.salina showed low toxicity of EPG (LC 50 =1,508mg/L). Oral administration of EPG (50, 100 and 150mg/kg) significantly decreased the number of acetic acid-induced writhes, around 61.3%, 71.8% and 64.9% respectively. However, EPG failed to prolong the latency time in the hot plate test, suggesting that EPG predominantly inhibits peripheral pain mechanisms. The oral administration of EPG at doses of 50 and 100mg/kg significantly inhibited paw edema at 3rd h after the injection of the phlogistic agent by 34.5% and 37.5%, respectively. These data suggest that EPG has both antinociceptive and anti-inflammatory activities, and these effects may be attributed to inhibition of COX-2 and prostaglandin release.

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The Role of Manual Acupuncture and Morphine Administration on the Modulation of Capsaicin-Induced Edema in Rat Paw. A Blind Controlled Study

Cited by 10 publications

References 0 publications

Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study

Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study

Anti‐inflammatory actions of acupuncture

Antinociceptive and Anti-Inflammatory Effects of Hydroalcoholic Extract of Leaves of Piptadenia Gonoacantha (Mart.) Macbr. In Experimental Animal Models

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