The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?

Condic, Maureen L.

doi:10.1007/s12015-016-9648-6

Cited by 33 publications

(37 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many maternal effects are readily apparent through early, direct negative consequences during embryo life when they are disrupted. Across diverse species such effects encompass mutations that compromise essential early oocyte functions such as meiosis or yolk deposition, localized ooplasmic determinants in some species, and chromatin regulators and other factors that are required for genome programming and activation (Condic, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Many maternal effect genes in mammals have been described that impact key early processes, which, when disrupted, are associated with early embryo demise (Condic, 2016; Lu, Gao, Qin, & Li, 2017). Although the study of such mutations is valuable for understanding essential early developmental processes, its relevance to understanding long‐term phenotypic effects is limited.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Listening to mother: Long‐term maternal effects in mammalian development

Ruebel

Latham

2020

Molecular Reproduction Devel

View full text Add to dashboard Cite

The oocyte is a complex cell that executes many crucial and unique functions at the start of each life. These functions are fulfilled by a unique collection of macromolecules and other factors, all of which collectively support meiosis, oocyte activation, and embryo development. This review focuses on the effects of oocyte components on developmental processes that occur after the initial stages of embryogenesis. These include long-term effects on genome function, metabolism, lineage allocation, postnatal progeny health, and even subsequent generations.Factors that regulate chromatin structure, genome programming, and mitochondrial function are elements that contribute to these oocyte functions. K E Y W O R D S chromatin, embryo gene regulation, maternal effect, oocyte 400 |

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Listening to mother: Long‐term maternal effects in mammalian development

Ruebel

Latham

2020

Molecular Reproduction Devel

View full text Add to dashboard Cite

show abstract

“…The low transcriptional activity before zygotic genome activation indicates that maternal-effect genes play essential roles in early embryonic development (Li et al, 2013(Li et al, , 2010. Since the initial identification of the maternal-effect genes Nlrp5 (also known as Mater) and Hsf1 (Christians et al, 2000;Tong et al, 2000), dozens of maternal-effect genes have been reported (Condic, 2016;Li et al, 2010). Yet, how the maternal-effect genes regulate early embryonic development remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution

et al. 2019

View full text Add to dashboard Cite

In mammalian oocytes and embryos, the subcortical maternal complex (SCMC) and cytoplasmic lattices (CPLs) are two closely related structures. Their detailed compositions and functions remain largely unclear. Here, we characterize Nlrp4f as a novel component associated with the SCMC and CPLs. Disruption of maternal Nlrp4f leads to decreased fecundity and delayed preimplantation development in the mouse. Lack of Nlrp4f affects organelle distribution in mouse oocytes and early embryos. Depletion of Nlrp4f disrupts CPL formation but does not affect the interactions of other SCMC proteins. Interestingly, the loss of Khdc3 or Tle6, two other SCMC proteins, also disrupts CPL formation in mouse oocytes. Thus, the absence of CPLs and aberrant distribution of organelles in the oocytes caused by disruption of the examined SCMC genes, including previously reported Zbed3, Nlrp5, Ooep and Padi6, indicate that the SCMC is required for CPL formation and organelle distribution. Consistent with the role of the SCMC in CPL formation, the SCMC forms before CPLs during mouse oogenesis. Together, our results suggest that the SCMC protein Nlrp4f is involved in CPL formation and organelle distribution in mouse oocytes.

show abstract

“…Moreover, the application of newly developed techniques to investigate both preceding and subsequent stages, including gametogenesis − with particular focus on oocyte maternal factors (Li et al . 2010, Condic 2016), as well as preimplantation, peri-implantation and postimplantation embryos (Deglincerti et al . 2016, Shahbazi et al .…”

Section: Discussionmentioning

confidence: 99%

Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!

Fraser

Lin

2016

Reproduction

View full text Add to dashboard Cite

Gametogenesis (spermatogenesis and oogenesis) is accompanied by the acquisition of gender-specific epigenetic marks, such as DNA methylation, histone modifications and regulation by small RNAs, to form highly differentiated, but transcriptionally silent cell-types in preparation for fertilisation. Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce totipotent zygotic states. It is the aim of this review to delineate the cellular and molecular events involved in maternal, paternal and zygotic epigenetic reprogramming from the time of gametogenesis, through fertilisation, to the initiation of zygotic genome activation for preimplantation embryonic development. Recent studies have begun to uncover the indispensable functions of epigenetic players during gametogenesis, fertilisation and preimplantation embryo development, and a more comprehensive understanding of these early events will be informative for increasing pregnancy success rates, adding particular value to assisted fertility programmes.

show abstract

The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?

Cited by 33 publications

References 148 publications

Listening to mother: Long‐term maternal effects in mammalian development

Listening to mother: Long‐term maternal effects in mammalian development

The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution

Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!

Contact Info

Product

Resources

About