The role of maternal hormones in regulating autonomic functions during pregnancy

Abstract

Offspring development relies on numerous physiological changes that occur in a mother's body, with hormones driving many of these adaptations. Amongst these, the physiological functions controlled by the autonomic nervous system are required for the mother to survive and are adjusted to meet the demands of the growing foetus and to ensure a successful birth. The hormones oestrogen, progesterone, and lactogenic hormones rise significantly during pregnancy, suggesting they may also play a role in regulating the maternal adaptations linked to autonomic nervous system functions, including respiratory, cardiovascular, and thermoregulatory functions. Indeed, expression of pregnancy hormone receptors spans multiple brain regions known to regulate these physiological functions. This review examines how respiratory, cardiovascular, and thermoregulatory functions are controlled by these pregnancy hormones by focusing on their action on central nervous system circuits. Inadequate adaptations in these systems during pregnancy can give rise to several pregnancy complications, highlighting the importance in understanding the mechanistic underpinnings of these changes and potentially identifying ways to treat pregnancy‐associated afflictions using hormones.This article is protected by copyright. All rights reserved.

Pregnancy, Kidneys, Hypertension

“…Не только нарушения уродинамики увеличивают почку, но и её полнокровие. В результате скоординированного действия релаксина, хорионического гонадотропина, эстрадиола и прогестерона при беременности во всём организме происходит системная вазодилятация [4]. (рисунок 1, В).…”