The role of matrix metalloproteinases and their inhibitors in physiopathological processes in children with kidney diseases

Krutova, Alexandra; Лучанинова, В. Н.; Семешина, О В; Ni, Andrzheiuk; Быкова, О. Г.

doi:10.34215/1609-1175-2020-1-11-15

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They perform an important function in many physiological and pathological processes. Metalloproteinases are secreted by many cells, including fibrocytes, epithelial and oncotransformed cells, phagocytes, leukocytes, and vascular myocytes [3]. Insufficiency of the program of enzymatic cleavage of the extracellular and extracellular matrix leads to a decrease in the control of proliferative processes, and the adjuvant role of hexavalent nickel as a simulator of LPO-mediated events leads to mitochondria-mediated stimulation of accelerated mitosis.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of Matrix Metalloproteinase 9 Gene (rs17576) in Nickel-Exposed Children of the Far North

Mazunina¹,

Dolgikh²,

Zaitseva³

2020

Proceedings of the International Conference “Health and Wellbeing in Modern Society” (ICHW 2020)

View full text Add to dashboard Cite

Man-made changes in the environment lead to an increase in the risk to public health. The greatest danger, in the opinion of ecologists, biologists and physicians, is technospheric pollution with heavy metals, including nickel. Nickel intoxication is accompanied by mutagenic, carcinogenic, cardiotoxic effects; it has hematotropic and immunotropic effects. The article purpose is to study the genetic status of children living in the Arctic and exposed to nickel. A survey of 136 children 3-12 years old was carried out. The observation group included 82 children with excess nickel in their blood. The comparison group included 54 children whose blood nickel content did not exceed the reference level. Genetic analysis of the frequency of polymorphism of the matrix metalloproteinase gene MMP9 (Gln279Arg, rs17576) was carried out by realtime PCR with further allelic discrimination. According to the results of studies of the health status of the child population, the presence of early changes in the immune system was revealed, which are manifested in the hyperproduction of class A immunoglobulins in children of the observation group (p < 0.05). It was found that the occurrence of the minor G allele of the MMP9 gene (rs17576) in the observation group is 45 %, which is 1.7 times higher than that in the comparison group (p < 0.05). The detected excess frequency of the G allele of the MMP9 gene (rs17576) in children of the Far North living in a technogenic "nickel" province is associated with insufficient processes of destruction of the extracellular matrix, which creates a danger of the emergence and development of proliferative and oncological conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Polymorphism of Matrix Metalloproteinase 9 Gene (rs17576) in Nickel-Exposed Children of the Far North

Mazunina¹,

Dolgikh²,

Zaitseva³

2020

Proceedings of the International Conference “Health and Wellbeing in Modern Society” (ICHW 2020)

View full text Add to dashboard Cite

show abstract

Determination of the relationship between the polymorphic genes of metaloproteinases MMP9 (A-8202G) RS11697325 and the level of cystatin c in children with chronic nephritic syndrome

Bazarova,

Akhedov,

Oltiboyeva

et al. 2024

BIO Web Conf.

View full text Add to dashboard Cite

An analysis of the scientific literature in recent years reliably indicates the importance of molecular diagnostics in the field of nephrology. Research contains information on the role of genetic factors in the chronicization of the process of nephritic syndrome, ongoing research in this area. The pathology of development is explained by the fact that the chronicity of the process occurs primarily due to genetic inferiority of parts of the nephron, which leads to changes in the structure of the protein. The results of the study show the relationship between changes in the genotype of MMP9 (Matrix metalloproteinase-9) (A-8202G) rs11697325 with the development of the chronicization process. Our results provide evidence that cystatin C is an accurate diagnostic and prognostic marker of chronic nephritic syndrome in the pediatric population. At the same time, chromosomal polymorphic MMP9 genes affect the glomerular filtration rate by increasing the amount of Cystatin C, which is a gold marker in the diagnosis of chronic nephritic syndrome in children, determining the prognosis of the disease, which makes it possible for timely treatment and further tactics of the doctor.

show abstract

The role of matrix metalloproteinases and their inhibitors in physiopathological processes in children with kidney diseases

Cited by 2 publications

References 16 publications

Polymorphism of Matrix Metalloproteinase 9 Gene (rs17576) in Nickel-Exposed Children of the Far North

Polymorphism of Matrix Metalloproteinase 9 Gene (rs17576) in Nickel-Exposed Children of the Far North

Determination of the relationship between the polymorphic genes of metaloproteinases MMP9 (A-8202G) RS11697325 and the level of cystatin c in children with chronic nephritic syndrome

Contact Info

Product

Resources

About