The Role of Medication in Spontaneous Gastrocutaneous Fistula Closure

Thomas, Priscilla; Sharp, Nicole E.; Schnell, Katherine R.; Snyder, Charles L.; Peter, Shawn D. St.

doi:10.1055/s-0034-1396417

Cited by 6 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This nding could have been impacted by the reduced cohort size in our analysis of persistent GCF occurrence and perioperative complications (n = 46 and n = 82, respectively) compared to our analysis of all complications (n = 108). Previous studies (n < 100) also indicate that PPIs and steroids ± have no effect on the likelihood of persistent GCF occurrence [13,15,29]. Regarding perioperative complications, a larger paediatric study (n = 425,251) concluded that chronic steroid use was associated with increased perioperative complications across all types of surgery [30].…”

Section: Discussionmentioning

confidence: 96%

“…The literature is divided on a number of potential risk factors, with some nding that younger age at gastrostomy insertion [12,13,16], concomitant Nissen fundoplication [13,16], and open gastrostomy insertion technique [12,13,16,17] are associated with increased persistent GCF occurrence. Data from our study did not support these ndings and was in accordance with a number of paediatric studies [5,[7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…It provides an opening for gastric content leakage and subsequently, potential cutaneous injury, infection, pain, loss of nutrients or dehydration [10]. Multiple studies have identi ed risk factors associated with the development of a persistent GCF [5,[7][8][9][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications & Growth Outcome

Nguyen,

Kennedy,

Varajavandi

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose To determine the incidence of and risk factors for complications after gastrostomy tube removal in children and to investigate whether complications are associated with growth outcome. Methodology: Medical records of 108 patients, who underwent gastrostomy removal and gastrostomy site closure, between January 2014 to July 2022 at a single institution, were reviewed. Clinical factors were analysed for association with complications and growth outcomes. Results Complications occurred in 39% (42/108) of patients. Persistent gastrocutaneous fistula (GCF) (20/108, 18%) and perioperative complications (16/82, 20%) were most frequent. Attempted non-operative closure (NOC), PPI use, and steroid use were more frequent in patients with complications (64.3% vs 28.8%, p = 0.001; 57.3% vs 32.3%, p = 0.029; 29.3% vs 12.5%, p = 0.033 respectively). Patients with persistent GCF had longer mean duration of gastrostomy placement (40.45 ± 35.36 vs 15.96 ± 16.94 months, p=0.008) and greater occurrence of pre-existing non-reflux gastrointestinal disease (40% vs 12%, p=0.038). Mean growth z-scores were maintained at 6 months, 18 months and 5 years follow-up in patients with and without complications. Conclusion Attempted NOC, PPIs, and steroids were risk factors for complications after gastrostomy removal. Longer duration of gastrostomy placement and non-reflux gastrointestinal disease were risk factors for persistent GCF. Complications were not associated with poorer growth outcome.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications & Growth Outcome

Nguyen,

Kennedy,

Varajavandi

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…There are different factors that contribute to persistent gastrocutaneous fistula in children after its removal. Age of patient at time of insertion, method of insertion, and duration of gastrostomy tube are most common factors related to failure of spontaneous closure [5].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic management of persistent gastrocutaneous fistula after feeding gastrostomy appliance removal in children

Khirallah

Bustangi

2020

Ann Pediatr Surg

View full text Add to dashboard Cite

Background Feeding gastrostomy is widely used in children that have troubles of swallowing and need to stablish enteral feeding. There are several methods for creation of that stoma. After the children gain their normal ability of swallowing, this tube or appliance is removed. Failure of spontaneous closure of gastrostomy opening after removal of the tube was reported with an incidence of 0.5 to 3.9%. The purpose of authors was to study laparoscopic management of persistent gastrocutaneous fistula after failure of conservative measures. Results There were 19 patients, 12 males. Main cause for feeding gastrostomy was neurological. Most feeding gastrostomy tubes were inserted endoscopically. The mean operative time was 57 ± 10.2 min. The mean time of full oral intake was 24 ± 3.5 h. No wound infection had developed. There was no recurrence of fistula after management. Conclusion Laparoscopic management of persistent gastrocutaneous fistula is safe, feasible, and associated with no recurrence of fistula.

show abstract

“…En un estudio retrospectivo pediátrico se incluyeron 97 niños en tratamiento con ranitidina, inhibidor de bomba de protones o ambos. No hubo diferencia en la frecuencia de cierre de la FGC (ranitidina p = 0.09, inhibidor de bomba de protones p = 0.83 y ambos p = 0.06, respectivamente) 11 .…”

Section: Discussionunclassified

Cierre endoscópico de fístula gastrocutánea posterior al retiro de sonda de gastrostomía: reporte de caso

Zamarripa-Mottú

Murcio-Pérez

Blanco‐Velasco

et al. 2019

END

View full text Add to dashboard Cite

Se presenta el caso de una paciente de 45 años con FGC posterior a retiro de sonda de gastrostomía, en quien se realizó cierre exitoso con dispositivo endoscópico Ovesco®. Las terapias endoscópicas más efectivas son las que combinan desepitelización del trayecto fistuloso con método mecánico o monoterapia con Oves-co®. Los dispositivos de cierre endoscópico tienen alta eficacia y seguridad como tratamiento de la FGC y deben considerarse como la primera opción de tratamiento.

show abstract

The Role of Medication in Spontaneous Gastrocutaneous Fistula Closure

Abstract: Ranitidine or PPI use upon removal of gastrostomy tubes does not seem to facilitate spontaneous GCF closure in children.

Cited by 6 publications

References 18 publications

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications & Growth Outcome

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications & Growth Outcome

Laparoscopic management of persistent gastrocutaneous fistula after feeding gastrostomy appliance removal in children

Cierre endoscópico de fístula gastrocutánea posterior al retiro de sonda de gastrostomía: reporte de caso

Contact Info

Product

Resources

About

The Role of Medication in Spontaneous Gastrocutaneous Fistula Closure

Abstract: Ranitidine or PPI use upon removal of gastrostomy tubes does not seem to facilitate spontaneous GCF closure in children.

Cited by 6 publications

References 18 publications

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications &amp; Growth Outcome

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications &amp; Growth Outcome

Laparoscopic management of persistent gastrocutaneous fistula after feeding gastrostomy appliance removal in children

Cierre endoscópico de fístula gastrocutánea posterior al retiro de sonda de gastrostomía: reporte de caso

Contact Info

Product

Resources

About

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications & Growth Outcome

Clinical Outcomes After Gastrostomy Tube Removal in Children: Risk Factors for Complications & Growth Outcome