The Role of Melatonin and Bromocriptine in the Regulation of Prolactin Secretion in Animals – A Review

Molik, Edyta; Błasiak, M

doi:10.1515/aoas-2015-0042

Cited by 7 publications

(4 citation statements)

References 53 publications

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“…To test this hypothesis, we acutely inhibited PRL release during sexual behavior by taking advantage of bromocriptine, a D2 receptor agonist. Bromocriptine's activation of D2 receptors on the lactotrophs' membrane blocks PRL release, a well-established procedure to inhibit the discharge of this hormone from the pituitary 31,51 . If PRL is indeed necessary for the establishment of the PERP, we expected that after ejaculation, drug-treated males to regain sexual motivation faster than controls.…”

Section: Blocking Prolactin Release During Copulation Does Not Decreamentioning

confidence: 99%

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

Valente

Marques

Lima

2020

Preprint

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In many species, ejaculation is followed by a state of decreased sexual motivation, the post-ejaculatory refractory period. Several lines of evidence have suggested prolactin, a pituitary hormone released around the time of ejaculation in humans and other animals, to be a decisive player in the establishment of the refractory period. However, data supporting this hypothesis is controversial. We took advantage of two different strains of house mouse, a wild derived and a classical laboratory strain, that differ substantially in their sexual behavior, to investigate prolactin's involvement in sexual motivation and the refractory period. First, we show that there is prolactin release during sexual behavior in male mice. Second, using a pharmacological approach, we show that acute manipulations of prolactin levels, either mimicking the natural release during sexual behavior or inhibiting its occurrence, do not affect sexual motivation or shorten the refractory period, respectively. Therefore, we show compelling evidence refuting the idea that prolactin released during copulation is involved in the establishment of the refractory period, a long-standing hypothesis in the field of behavioral endocrinology.

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Section: Blocking Prolactin Release During Copulation Does Not Decreamentioning

confidence: 99%

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

Valente

Marques

Lima

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…To test this hypothesis, we acutely inhibited PRL release during sexual behavior by taking advantage of bromocriptine, a D2 receptor agonist. Bromocriptine’s activation of D2 receptors on the lactotrophs’ membrane blocks PRL release, a well-established procedure to inhibit the discharge of this hormone from the pituitary 34 , 52 . If PRL is indeed necessary for the establishment of the PERP, we expected that after ejaculation, drug-treated males would regain sexual activity faster than controls.…”

Section: Resultsmentioning

confidence: 99%

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

2021

View full text Add to dashboard Cite

In many species, ejaculation is followed by a state of decreased sexual activity, the post-ejaculatory refractory period. Several lines of evidence have suggested prolactin, a pituitary hormone released around the time of ejaculation in humans and other animals, to be a decisive player in the establishment of the refractory period. However, data supporting this hypothesis is controversial. We took advantage of two different strains of house mouse, a wild derived and a classical laboratory strain that differ substantially in their sexual performance, to investigate prolactin’s involvement in sexual activity and the refractory period. First, we show that there is prolactin release during sexual behavior in male mice. Second, using a pharmacological approach, we show that acute manipulations of prolactin levels, either mimicking the natural release during sexual behavior or inhibiting its occurrence, do not affect sexual activity or shorten the refractory period, respectively. Therefore, we show compelling evidence refuting the idea that prolactin released during copulation is involved in the establishment of the refractory period, a long-standing hypothesis in the field of behavioral endocrinology.

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“…Reducing PRL during non-breeding seasons induces off-season estrus in sheep [24]. Bromocriptine (BCR), a commonly used dopamine agonist [25][26][27], can reduce PRL levels in the body [28], thus alleviating hypogonadism, infertility, galactorrhea, oligomenorrhea, and amenorrhea due to serum PRL elevation [29,30]. However, the regulation of the estrus cycle in sheep via PRL inhibition remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Prolactin on Gene Expression and the Secretion of Reproductive Hormones in Ewes during the Estrus Cycle

Yue,

Chen,

Duan

et al. 2024

Animals

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Prolactin (PRL) plays an important role in animal follicle development and ovulation. However, its regulatory effects on the different stages of the estrus cycle in ewes are unclear. In this study, bromocriptine (BCR, PRL inhibitor) was used to study the effect of PRL on the secretion of reproductive hormones and gene expressions in order to explore its regulatory effects on the sexual cycle of ewes. Eighty healthy ewes with the same parity and similar weights were randomly assigned to the control group (C, n = 40) and the treatment group (T, n = 40, fed bromocriptine). After estrus synchronization, thirty-one ewes with overt signs of estrus were selected from each group. Six blood samples were randomly obtained by jugular venipuncture to measure the concentration of PRL, estrogen (E2), progesterone (P4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and gonadotropin-releasing hormone (GnRH) in the proestrus, estrus, metestrus, and diestrus. At the same time, we collected the ovaries of the six ewes in vivo after anesthesia in order to detect follicle and corpus luteum (CL) counts and measure the expression of hormone-receptor and apoptosis-related genes. The results show that PRL inhibition had no significant effects on the length of the estrus cycle (p > 0.05). In proestrus, the number of large and small follicles, the levels of E2, FSH, and GnRH, and the expressions of ER, FSHR, and the apoptotic gene Caspase-3 were increased (p < 0.05); and the number of middle follicles and the expression of anti-apoptotic gene Bcl-2 were decreased (p < 0.05) in the T group. In estrus, the number of large follicles, the levels of E2 and GnRH, and the expressions of the StAR, CYP19A1, and Bcl-2 genes were increased (p < 0.05), and the number of middle follicles was decreased (p < 0.05) in the T group. In metestrus, the number of small follicles and the expression of LHR (p < 0.05) and the pro-apoptotic gene Bax were increased (p < 0.05); the number of middle follicles was decreased (p < 0.05) in the T group. In diestrus, the number of large follicles, middle follicles, and CL, the level of P4, and the expressions of PR, 3β-HSD, StAR, Caspase-3, and Bax were increased (p < 0.05); the number of small follicles and the expression of Bcl-2 were decreased (p < 0.05) in the T group. In summary, PRL inhibition can affect the secretion of reproductive hormones, the follicle count, and the gene expression during the estrus cycle. These results provide a basis for understanding the mechanisms underlying the regulation of the ewe estrus cycle by PRL.

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The Role of Melatonin and Bromocriptine in the Regulation of Prolactin Secretion in Animals – A Review

Cited by 7 publications

References 53 publications

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

The Effect of Prolactin on Gene Expression and the Secretion of Reproductive Hormones in Ewes during the Estrus Cycle

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