The role of melatonin as an adjuvant in the treatment of COVID-19: A systematic review

Faridzadeh, Arezoo; Tabashiri, Arefeh; Miri, Hamid Heidarian; Mahmoudi, Mahmoud

doi:10.1016/j.heliyon.2022.e10906

Cited by 16 publications

(11 citation statements)

References 47 publications

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“…It is used in the treatment of critical care patients to reduce anxiety, vessel permeability, use of sedation, and improve sleep quality [ 30 ]. The cost-effectiveness, minor side effects, and properties of melatonin, such as anti-viral properties, an antioxidant enzyme inducer, apoptosis regulator, immune function stimulator, and free radical scavenger, make it a potential adjuvant in the treatment of COVID-19 patients and other viral infections [ 215 , 216 , 217 ]. Melatonin prevents fibrosis which is a complication of COVID-19.…”

Section: Therapeutic Management Of Renal Disorder Patients With Covid-19mentioning

confidence: 99%

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

et al. 2023

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a respiratory disorder. Various organ injuries have been reported in response to this virus, including kidney injury and, in particular, kidney tubular injury. It has been discovered that infection with the virus does not only cause new kidney disease but also increases treatment difficulty and mortality rates in people with kidney diseases. In individuals hospitalized with COVID-19, urinary metabolites from several metabolic pathways are used to distinguish between patients with acute kidney injury (AKI) and those without. This review summarizes the pathogenesis, pathophysiology, treatment strategies, and role of metabolomics in relation to AKI in COVID-19 patients. Metabolomics is likely to play a greater role in predicting outcomes for patients with kidney disease and COVID-19 with varying levels of severity in the near future as data on metabolic profiles expand rapidly. Here, we also discuss the correlation between COVID-19 and kidney diseases and the available metabolomics approaches.

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Section: Therapeutic Management Of Renal Disorder Patients With Covid-19mentioning

confidence: 99%

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

et al. 2023

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“…The Authors' of the systematic review [133] concluded that studies "demonstrate that melatonin supplementation at a dosage of 3-10 mg/day (or 2 mg of prolonged release in an Italian trial [135]) is associated with an improvement in clinical outcomes in COVID-19 patients". Moreover "melatonin could be a potential adjuvant in the treatment of COVID-19 patients if administered for two weeks and can possibly help to reduce recovery time, mortality rate, and the likelihood of coagulopathy disorder or sepsis.…”

Section: Melatoninmentioning

confidence: 99%

“…Figure 12. Random effects meta-analysis for all RCTs about melatonin in COVID-19 [133][134][135][136][137][138][139][140][141][142][143][144][145][146]. This plot shows pooled effects, see the specific outcome analyses for individual outcomes, and the heterogeneity section [21] for discussion.…”

Section: Melatoninmentioning

confidence: 99%

Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review

Donzelli

2023

Preprint

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The official recommendations to manage COVID-19 in the outpatient setting focus on high-cost drugs (remdesivir, nirmatrelvir-ritonavir, molnupiravir), suffering from many problems. Therefore, one may consider also other treatments meeting these criteria: • promising effectiveness, based on favorable randomized controlled trials (RCTs) of sufficient validity. Even without definitive evidence, physicians and informed patients can consider them if they are also: • safe, to the state of knowledge • with a very favorable opportunity cost • biologically plausible/not implausible • accessible • without major commercial sponsors in the trials promoting them, and with researchers without major conflicts of interests. The main focus is on a limited group of functional foods and some their active ingredients, with further mention of other substances of different origin, yet fully meeting all the aforementioned criteria. The functional foods and substances described and discussed certainly do not cover all the known effective therapies for COVID-19 (in one case also for Long-COVID), but the only therapies proposed in this paper currently satisfy all the above criteria. The supporting scientific evidence will favor meta-analyses of RCTs that include the most definitive outcome: all-cause mortality, i.e. the outcome that most fully informed people tend to prioritize. Furthermore, the reported evidence favors clinical studies of the most valid design, i.e. RCTs.

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“…Increasing evidence has proved that melatonin as an adjunctive agent exhibited beneficial effects for COVID-19 prevention and treatment [ 178 , 179 ], although there is still no direct evidence supporting the possible role of melatonin in COVID-19 outcomes with periodontitis patients. It is hypothesized that melatonin may prevent the activation of NLRP3 inflammasome, thus protect tissue damage from COVID-19 and periodontitis [ 180 ].…”

Section: Melatonin and Periodontitis-related Systemic Diseases: Far M...mentioning

confidence: 99%

Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity

Wang

et al. 2022

IJMS

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Periodontitis as a highly prevalent chronic infection/inflammatory disease can eventually lead to tooth loss and masticatory dysfunction. It also has a negative impact on general health and largely impairs quality of life. The tissue destruction during periodontitis is mainly caused by the excessive immune–inflammatory response; hence, how to modulate the host’s reaction is of profound importance for effective periodontal treatment and tissue protection. Melatonin, as an endogenous hormone exhibiting multiple biological functions such as circadian rhythm regulation, antioxidant, and anti-inflammation, has been widely used in general healthcare. Notably, the past few years have witnessed increasing evidence for the application of melatonin as an adjunctive approach in the treatment of periodontitis and periodontitis-related systemic comorbidities. The detailed underlying mechanisms and more verification from clinical practice are still lacking, however, and further investigations are highly required. Importantly, it is essential to establish standard guidelines in the near future for the clinical administration of melatonin for periodontal health and general wellbeing.

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The role of melatonin as an adjuvant in the treatment of COVID-19: A systematic review

Cited by 16 publications

References 47 publications

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches

Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review

Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity

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