The role of melatonin supplement in metabolic syndrome

Abstract

Purpose Metabolic syndrome contains metabolic disorders that have association with other chronic diseases. Melatonin is a bioactive compound which is found in plants and also produced in the body. The purpose of this paper is to assess the effect of melatonin supplement on metabolic syndrome components, also leptin and adiponectin blood concentrations in patients with metabolic syndrome. Design/methodology/approach A double blind, placebo-controlled, randomized clinical trial was conducted on 70 subjects with metabolic syndrome. Participants received 6 mg/day melatonin or placebo before bedtime for 12 weeks. At the beginning and end of treatment period, blood samples were collected and biochemical parameters were measured. In addition, blood pressure and anthropometric indices were examined before and after the supplementation. Independent sample t-test was used to compare changes in metabolic syndrome components between the two study groups. Findings Results showed a significant reduction in waist circumference (−1.54 vs −0.04 cm; p = 0.036), systolic blood pressure (−3.52 vs 0.79 mmHg; p = 0.020), diastolic blood pressure (−1.50 vs 1.73 mmHg; p = 0.014), serum leptin concentration (−2.54 vs 0.27ng/ml; p = 0.041) and an elevation in high-density lipoprotein cholesterol (2.19 vs −0.79 mg/dl; p = 0.038) in the melatonin group compared to the placebo. Research limitations/implications If insulin concentration had been measured, it might have revealed better interpretation of melatonin effect on fasting blood glucose. Originality/value This study showed that melatonin as a nutritional supplement improved most metabolic syndrome components and concentration of leptin in the melatonin group compared to the placebo.

Exogenous melatonin decreases circadian misalignment and body weight among early types

“…It is worth mentioning that both groups underwent supplementation (melatonin or placebo) and a calorie-restricted diet. A similar result was observed by Bahrami et al 66 in a study of 12 weeks of supplementation with 6 mg of melatonin (one hour before the desired time to sleep) in 70 individuals with metabolic syndrome. The authors found a significant reduction in body weight, waist, and abdominal circumference, in addition to a tendency to reduce BMI in comparison with the placebo.…”

The Prevalence of Metabolic Syndrome in Ethiopian Population: A Systematic Review and Meta-analysis

“…The findings were also lower as compared to Palestine (37.0%) [ 70 ], the Greek population (43.4%) [ 71 ], and the population of Nepal (52.7%) [ 72 ]. The variation in reports might be due to the difference in the underling important risk factors such as urbanization, westernization of lifestyle including unhealthy diet and physical inactivity [ 73 ], mental stress due to economic, social, and cultural factors [ 74 ], genetics, proinflammatory condition [ 75 ], intrauterine growth retardation, and over nutrition increasing on top of the already high prevalence of under nutrition [ 76 ].…”

Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta‐analysis

“…After duplicate removal, abstract screening and full-text reviews, eleven studies were included in the systematic review and meta-analysis and none was found to have been published in a predatory journal. [15][16][17][18][27][28][29][30][31][32][33]…”

“…The summarized study characteristics are prestend in Table 1 and a structured risk of bias assessment in the individual studies are presented in Table 2. Seven studies had low risk of bias 16,17,28,[30][31][32][33] and four studies had some concerns. 15,18,27,29 Abood et al 27 randomized 40 women with metabolic syndrome 1:1 to receive either 500 mg metformin × 2 and placebo × 1 or 500 mg metformin × 2 and 10 mg melatonin × 1 for 90 days.…”