The Role of Melatonin to Ameliorate Oxidative Stress in Sperm Cells

Makris, Achilleas; Alevra, Alexandra I.; Exadactylos, Athanasios; Papadopoulos, Serafeim

doi:10.3390/ijms242015056

Cited by 9 publications

(6 citation statements)

References 253 publications

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“…Furthermore, melatonin interacts with calmodulin, which act as an intracellular regulator of calcium function identified both in head and flagellar parts of spermatozoa and is believed to be a major signal transducer of calcium in regulating motility (Ramadan et al, 2019). Further, melatonin also stimulates cellular influx of calcium into sperm cells that control the transition of flagella wave forms from symmetric to asymmetric, thereby enhancing motility (Makris et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Effect of exogenous melatonin implant on post‐thaw semen quality of buffalo bulls

Grover,

Singh,

Kumar

et al. 2024

Reprod Domestic Animals

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Melatonin is an intracellular antioxidant of sperm membrane that protects the cells from lipid peroxidation. Yet, its role as an antioxidant on semen quality of buffalo bulls is still obscure. The present study was undertaken to assess the effect of exogenous melatonin implant (18 mg/50 kg bodyweight) on post‐thaw sperm characteristics, oxidative stress, endocrinological profiles and fertility of buffalo bulls. Six apparently healthy breeding Murrah buffalo bulls were randomly selected at bull farm, Guru Angad Dev Veterinary and Animal Sciences University for the present study and divided into two groups viz. control (n = 3) and melatonin implanted group (n = 3). A total of 120 ejaculates were collected from bulls of both groups (n = 60 each) throughout the study period. Most beneficial effects of melatonin implants were observed during post‐implantation period. The percentages of post‐thaw sperm total and progressive motility, viability and mitochondrial membrane potential were higher (p < .05) in melatonin implanted buffalo bulls compared to controls during post‐implantation period. Following melatonin implantation, MDA production in post‐thaw semen was lower (p < .05) in melatonin implanted group than in control group. Plasma melatonin and testosterone concentrations were higher (p < .05) in buffalo bulls implanted with melatonin as compared to their control counterparts. No differences (p > .05) in plasma LH concentrations were observed in both groups. First service pregnancy rate was 43.3% using semen of melatonin implanted bulls and 30.0% with semen of controls (p > .05). Thus, melatonin was able to protect sperm membrane against oxidative damage and improve post‐thaw semen quality, thereby resulting in higher fertilizing potential of spermatozoa.

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Section: Discussionmentioning

confidence: 99%

Effect of exogenous melatonin implant on post‐thaw semen quality of buffalo bulls

Grover,

Singh,

Kumar

et al. 2024

Reprod Domestic Animals

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“…Our primary objective was to incorporate the most pertinent and up-to-date scholarly contributions, while also preserving the essential context for a comprehensive understanding. To assess the impact of heat stress on mammalian reproductive cells, we primarily focused on articles published In response to these challenges, numerous researchers have advocated for exogenous supplementation with antioxidants to mitigate the elevated levels of reactive oxygen species (ROS) induced by HS and enhance the antioxidant capacity of mammalian reproductive cells [30,31,47,[73][74][75][76]. Consistently, positive outcomes have been observed for supplementation with antioxidants, whether in the form of herbal medicines or feed additives, in improving the efficiency of mammalian reproductive cells such as granulosa cells, Leydig cells, and Sertoli cells by alleviating oxidative stress [77][78][79][80][81][82][83][84][85].…”

Section: Literature Search and Selection Criteriamentioning

confidence: 99%

“…In response to these challenges, numerous researchers have advocated for exogenous supplementation with antioxidants to mitigate the elevated levels of reactive oxygen species (ROS) induced by HS and enhance the antioxidant capacity of mammalian reproductive cells [ 30 , 31 , 47 , 73 , 74 , 75 , 76 ]. Consistently, positive outcomes have been observed for supplementation with antioxidants, whether in the form of herbal medicines or feed additives, in improving the efficiency of mammalian reproductive cells such as granulosa cells, Leydig cells, and Sertoli cells by alleviating oxidative stress [ 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ].…”

Section: Introductionmentioning

confidence: 99%

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Khan,

Chen

et al. 2024

Antioxidants

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Heat stress represents a pervasive global concern with far-reaching implications for the reproductive efficiency of both animal and human populations. An extensive body of published research on heat stress effects utilizes controlled experimental environments to expose cells and tissues to heat stress and its disruptive influence on the physiological aspects of reproductive phenotypic traits, encompassing parameters such as sperm quality, sperm motility, viability, and overall competence. Beyond these immediate effects, heat stress has been linked to embryo losses, compromised oocyte development, and even infertility across diverse species. One of the primary mechanisms underlying these adverse reproductive outcomes is the elevation of reactive oxygen species (ROS) levels precipitating oxidative stress and apoptosis within mammalian reproductive cells. Oxidative stress and apoptosis are recognized as pivotal biological factors through which heat stress exerts its disruptive impact on both male and female reproductive cells. In a concerted effort to mitigate the detrimental consequences of heat stress, supplementation with antioxidants, both in natural and synthetic forms, has been explored as a potential intervention strategy. Furthermore, reproductive cells possess inherent self-protective mechanisms that come into play during episodes of heat stress, aiding in their survival. This comprehensive review delves into the multifaceted effects of heat stress on reproductive phenotypic traits and elucidates the intricate molecular mechanisms underpinning oxidative stress and apoptosis in reproductive cells, which compromise their normal function. Additionally, we provide a succinct overview of potential antioxidant interventions and highlight the genetic biomarkers within reproductive cells that possess self-protective capabilities, collectively offering promising avenues for ameliorating the negative impact of heat stress by restraining apoptosis and oxidative stress.

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“…Environmental factors, such as light and temperature, play a crucial role in guiding animals to adopt the most suitable life strategy to optimize their reproductive success and ensure the survival of offspring. Melatonin, the major hormone responsible for integrating both annual and circadian cues in the organism, is synthesized by the pineal gland and eyes and acts as an endogenous clock regulating some biological processes such as reproduction in vertebrates (Li et al, 2023;Makris et al, 2023) including fish species (Falcón et al, 2010(Falcón et al, , 2011Lombardo et al, 2014;Maitra and Hasan, 2016;Guellard et al, 2019;Krylov et al, 2021). It is known that brain melatonin receptor activation regulates gonadotropin-releasing hormone (GnRH) gene expression and secretion, and consequently the secretion of pituitary gonadotropins as well as the production of steroids in the gonads in fish (Hofman, 2006;Parhar et al, 2012;Múñoz-Cueto et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

MELATONIN INDUCES CHANGES ON THE CIRCADIAN RHYTHMS OF REPRODUCTIVE HORMONES DURING SPERMATOGENESIS IN PUBERTAL MALE SEA BASS,Dicentrarchus labrax

Alvarado,

Espigares,

Carrillo

et al. 2024

Preprint

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Reproduction is a highly demanding biological process that occurs at the optimal time of the year and day to ensure the success of spawn and offspring. Melatonin is a hormone that, secreted mainly by the pineal gland, plays a critical role in the integration of the photoneuroendocrine information from environment (annual and daily variations) to modulate reproductive activity and gonadal development in fish. In this study we assessed the effect of exogenous melatonin on the circadian levels of sex steroids and gonadotropins in pubertal 2 yr-old male sea bass during their reproductive cycle including, pre-spermatogenesis (Pspg), spermiation (Spm) and post-spermiation (PSpm) stages. Our results demonstrated that all reproductive hormones displayed circadian variations along the entire reproductive cycle in pubertal fish. Circulating levels of the luteinizing hormone (Lh) were affected by both melatonin injection and the daily timing of administration during the Spm and PSpm stages, thus evoking variations of Lh levels at night. Melatonin also significantly affected circadian rhythms of Fsh during the Spm stage. Overall, both 11-Kt and T plasma levels displayed circadian variations during the reproductive cycle in the sea bass which were not prevented by melatonin. However, melatonin showed a significant decrease of plasma levels of 11-Kt 1h after dusk during the Pspg stage, while it increased those levels of T 5 h after dusk during the PSpm stage. These findings provide new insights into the role of melatonin in fish reproduction as a key factor in regulation of daily variation of key hormones involved in gonadal development. This circumstance may have implications in the control of gametogenesis and management of fish in aquaculture.HighlightsPlasma levels of Fsh, Lh, T and 11-Kt show daily rhythms in pubertal male sea bass.Melatonin evokes changes in daily rhythms of Lh during the reproductive cycle.Melatonin yields Fsh plasma level differences during spermiation stage.Melatonin elicits T and 11-Kt plasma level differences depending on reproductive stage and time.

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The Role of Melatonin to Ameliorate Oxidative Stress in Sperm Cells

Cited by 9 publications

References 253 publications

Effect of exogenous melatonin implant on post‐thaw semen quality of buffalo bulls

Effect of exogenous melatonin implant on post‐thaw semen quality of buffalo bulls

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

MELATONIN INDUCES CHANGES ON THE CIRCADIAN RHYTHMS OF REPRODUCTIVE HORMONES DURING SPERMATOGENESIS IN PUBERTAL MALE SEA BASS,Dicentrarchus labrax

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