The role of membrane vesiculation and encapsulation in cancer diagnosis and therapy

Drab, Mitja; Mesarec, Luka; Imani, Roghayeh; Jeran, Marko; Junkar, Ita; Kralj‐Iglič, Veronika; Kralj, Samo; Iglič, Aleš

doi:10.1016/bs.abl.2019.01.007

Cited by 3 publications

(4 citation statements)

References 164 publications

(199 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spherical vesicle at the tip of the nanotube is assumed to be stabilized by isotropic nanodomains characterized by positive (convex) curvature, while the nanotube is assumed to be formed from anisotropic cylindrical curvature-preferring membrane constituents or nanodomains (C 1m > 0, C 2m = 0). This can lead to the detachment of the tip vesicle into an extracellular vesicle [74]. Shapes with an up-down symmetry are stable only at lower values of the reduced volume [67].…”

Section: Membrane Protrusions Coupled With Local Curvature Changesmentioning

confidence: 99%

Inception Mechanisms of Tunneling Nanotubes

Drab

Stopar

Kralj‐Iglič

et al. 2019

Cells

Self Cite

View full text Add to dashboard Cite

Tunneling nanotubes (TNTs) are thin membranous tubes that interconnect cells, representing a novel route of cell-to-cell communication and spreading of pathogens. TNTs form between many cell types, yet their inception mechanisms remain elusive. We review in this study general concepts related to the formation and stability of membranous tubular structures with a focus on a deviatoric elasticity model of membrane nanodomains. We review experimental evidence that tubular structures initiate from local membrane bending facilitated by laterally distributed proteins or anisotropic membrane nanodomains. We further discuss the numerical results of several theoretical and simulation models of nanodomain segregation suggesting the mechanisms of TNT inception and stability. We discuss the coupling of nanodomain segregation with the action of protruding cytoskeletal forces, which are mostly provided in eukaryotic cells by the polymerization of f-actin, and review recent inception mechanisms of TNTs in relation to motor proteins.

show abstract

Section: Membrane Protrusions Coupled With Local Curvature Changesmentioning

confidence: 99%

Inception Mechanisms of Tunneling Nanotubes

Drab

Stopar

Kralj‐Iglič

et al. 2019

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

“…Upon additionally treating the electrochemically anodised TiO 2 NTs with oxygen plasma, surface contaminants are removed and an increase in oxygen content is observed. These oxygen plasma-treated NTs have beneficial effects on proliferation and adhesion of MG-63 cells [87]. It was also reported that oxygen plasma treatment also induces crystallisation of TiO 2 NTs from amorphous phase to rutile and/or anatase crystal structure.…”

Section: Additional Treatmentsmentioning

confidence: 89%

“…4E, left). This may cause the tip vesicle to separate and become an extracellular vesicle [87] (Fig. 4E, left).…”

Section: Anisotropic Membrane Components Modelsmentioning

confidence: 99%

Solid-supported lipid bilayer formation by solvent exchange

Cordoyiannis

Bar

Villanueva

et al. 2023

Advances in Biomembranes and Lipid Self-Assembly

View full text Add to dashboard Cite

“…with d i the effective diameter of species i. Ions with a high degree of solvation such as Li + have a large effective size; weakly solvated ions like Cs + have a small effective size. Drab et al [32] inferred from bulk permittivity data that g AM þ g X � 7:5 for NaCl electrolytes.…”

Section: Experimental Methodsmentioning

confidence: 99%

How Metal/Insulator Interfaces Enable an Enhancement of the Hydrogen Evolution Reaction Kinetics

Maier,

T. de Kam,

Golibrzuch

et al. 2024

ChemElectroChem

View full text Add to dashboard Cite

The nanostructuring of electrodes is a common way of increasing electrocatalytic activity. Yet, the fact that the presence of insulating material in nanostructured composites can have a positive effect on efficiency was an unexpected recent finding. The rate enhancement has been linked to different electric fields at the insulator and metal interfaces, facilitating enhanced transport of reaction products into the bulk electrolyte. In this article, we further uncover the origin of the rate enhancement with parameter studies and simulations. We experimentally investigate various parameter dependencies of the alkaline Hydrogen Evolution Reaction (HER) on well‐defined nanometer‐sized Au arrays embedded in a silicon nitride insulating layer. We find a significant enhancement of the HER for all experimental conditions and opposite activity trends with pH, electrolyte concentration and the cationic species compared to a continuous Au electrode. Using a mean field model, we quantify the electrostatic interfacial pressure above the Au and the insulator patches. Combining the double layer simulations with rate equations, we demonstrate that all parameter variations can be consistently explained by the fact that the double layer structure above the insulator patches is much less rigid than above the metal islands and is independent of the applied potential.

show abstract

The role of membrane vesiculation and encapsulation in cancer diagnosis and therapy

Cited by 3 publications

References 164 publications

Inception Mechanisms of Tunneling Nanotubes

Inception Mechanisms of Tunneling Nanotubes

Solid-supported lipid bilayer formation by solvent exchange

How Metal/Insulator Interfaces Enable an Enhancement of the Hydrogen Evolution Reaction Kinetics

Contact Info

Product

Resources

About