The role of mercury, selenium and the Se-Hg antagonism on cognitive neurodevelopment: A 40-month follow-up of the Italian mother-child PHIME cohort

Castriotta, Luigi; Rosolen, Valentina; Biggeri, Annibale; Ronfani, Luca; Catelan, Dolores; Mariuz, Marika; Bin, Maura; Brumatti, Liza Vecchi; Horvat, Milena; Barbone, Fabio

doi:10.1016/j.ijheh.2020.113604

Cited by 35 publications

(57 citation statements)

References 22 publications

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“…One RCT was also excluded because it was not possible to isolate the association be-tween the lactational supplement and the measurement of infant neurodevelopmental outcomes [57]. The remaining three studies included in the review were observational and were published between 2002 and 2020 [58][59][60]. Each included study differed in terms of infant neurodevelopmental outcome measurement, which BM micronutrient was studied, and the study design used.…”

Section: Study Selectionmentioning

confidence: 99%

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

“…Two of the included studies were conducted in high-income countries (HICs), Italy and Poland [59,60], and the third study did not report a location [58]. Sample size varied from a minimum of 25 mother-infant pairs in one study [58], to 370 mother-infant dyads included in the final analysis of the largest study [60]. All studies recruited mothers via convenience sampling from local hospitals [58][59][60], and one additionally invited participants to enrol through social media advertising [59,61].…”

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

“…Sample size varied from a minimum of 25 mother-infant pairs in one study [58], to 370 mother-infant dyads included in the final analysis of the largest study [60]. All studies recruited mothers via convenience sampling from local hospitals [58][59][60], and one additionally invited participants to enrol through social media advertising [59,61]. Participant characteristics varied between studies; in one study, all participants were of low socioeconomic status [58], whilst the other two studies recruited samples of disproportionately high educational attainment [59,60].…”

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

“…All studies recruited mothers via convenience sampling from local hospitals [58][59][60], and one additionally invited participants to enrol through social media advertising [59,61]. Participant characteristics varied between studies; in one study, all participants were of low socioeconomic status [58], whilst the other two studies recruited samples of disproportionately high educational attainment [59,60]. None of the papers reported including mothers at risk of or with known micronutrient deficiencies [58][59][60].…”

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

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Breast Milk Micronutrients and Infant Neurodevelopmental Outcomes: A Systematic Review

2021

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Micronutrients are fundamental for healthy brain development and deficiencies during early development can have a severe and lasting impact on cognitive outcomes. Evidence indicates that undernourished lactating individuals may produce breast milk containing lower concentrations of certain vitamins and minerals. Exclusively breastfed infants born to mothers deficient in micronutrients may therefore be at risk of micronutrient deficiencies, with potential implications for neurodevelopment. This systematic review aims to consider current knowledge on the effects of breast milk micronutrients on the developmental outcomes of infants. The databases Medline, Global Health, PsychInfo, Open Grey, and the Web of Science were searched for papers published before February 2021. Studies were included if they measured micronutrients in breast milk and their association with the neurodevelopmental outcomes of exclusively breastfed infants. Also, randomised control trials investigating neurocognitive outcomes following maternal supplementation during lactation were sought. From 5477 initial results, three observational studies were eligible for inclusion. These investigated associations between breast milk levels of vitamin B6, carotenoids, or selenium and infant development. Results presented suggest that pyroxidal, β-carotene, and lycopene are associated with infant neurodevelopmental outcomes. Limited eligible literature and heterogeneity between included papers prevented quantitative synthesis. Insufficient evidence was identified, precluding any conclusions on the relationship between breast milk micronutrients and infant developmental outcomes. Further, the evidence available was limited by a high risk of bias. This highlights the need for further research in this area to understand the long-term influence of micronutrients in breast milk, the role of other breast milk micronutrients in infant neurodevelopmental outcomes, and the impact of possible lactational interventions.

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Section: Study Selectionmentioning

confidence: 99%

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

Section: Study Setting and Participant Characteristicsmentioning

confidence: 99%

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Breast Milk Micronutrients and Infant Neurodevelopmental Outcomes: A Systematic Review

2021

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Fisheries Volume 49 Number 8 August 2024

2024

Fisheries

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Fish Tissue Mercury in Lakes and the Moderating Effects of Selenium

Hughes,

Peterson (Retired),

Van Sickle (Retired)

et al. 2024

Fisheries

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Fish mercury concentrations result in fish consumption advisories. However, selenium : mercury molar ratios >1 are protective to wildlife and humans. Therefore, we sampled total selenium (TSe) and total mercury (THg) concentrations and molar ratios in sport fish from 50 Idaho (ID) lakes >20 ha and 67 northeastern USA (NE) lakes >1 ha. Sample lakes were selected at random, to obtain unbiased estimates of mean fish tissue levels, with known confidence limits, for target populations of 95 ID lakes >20 ha in surface area and 12,557 NE lakes >1 ha. Bass and salmonids presented the greatest potential mercury toxicity risk to consumers based on their higher mercury content, desirability as game fish, and widespread distributions. Fish tissue THg exceeded safe consumption criteria in an estimated 20–80% of the lakes in the two regions and TSe exceeded safe consumption thresholds in an estimated 0–20% of the lakes in the two regions. However, the Se : Hg molar ratio was >1 in an estimated 90–97% of fish tested from NE and ID lakes. Therefore, we concluded that Se levels in these systems are usually sufficient to limit disruption of selenoprotein activities by Hg, and that fish consumption advisories based on Hg alone are unnecessarily restrictive.

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The role of mercury, selenium and the Se-Hg antagonism on cognitive neurodevelopment: A 40-month follow-up of the Italian mother-child PHIME cohort

Cited by 35 publications

References 22 publications

Breast Milk Micronutrients and Infant Neurodevelopmental Outcomes: A Systematic Review

Breast Milk Micronutrients and Infant Neurodevelopmental Outcomes: A Systematic Review

Fisheries Volume 49 Number 8 August 2024

Fish Tissue Mercury in Lakes and the Moderating Effects of Selenium

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