The role of mesoaccumbens-pallidal circuitry in novelty-induced behavioral activation

Hooks, M.S.; Kalivas, Peter W.

doi:10.1016/0306-4522(94)00409-x

Cited by 168 publications

(100 citation statements)

References 66 publications

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“…In contrast, earlier studies describing the inhibitory influence of D3 receptor on locomotion (Xu et al, 1997), as well as studies describing the effects of D3 antisense oligonucleotides on locomotion reaching a similar conclusion (Menalled et al, 1999;Ekman et al, 1998), evaluated D3 modulation of exploratory behavior in non-habituated animals. Unique mechanisms modulating novelty-induced exploratory locomotion have previously been described (Hooks and Kalivas, 1995). As we have previously suggested (Richtand et al, 2001b), these observations suggest that locomotor inhibitory effects of selective D3 agonists are most readily detected in a novel, nonacclimated environment.…”

Section: Novelty-stimulated Locomotion May Account For Divergent Findsupporting

confidence: 71%

7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment

Pritchard

Logue

Hayes

et al. 2003

Neuropsychopharmacol

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The D3 dopamine receptor is expressed primarily in limbic brain areas, and appears to play an inhibitory role in rodent locomotor behavior. Evidence suggests a potential role for the D3 receptor in the pathology of neuropsychiatric disease. Progress in elucidating D3 receptor function has been hampered, however, by a lack of well-characterized, selective ligands and by conflicting information regarding the behavioral phenotype of D3 receptor knockout mice. Here, we describe studies evaluating the behavioral effects of ( 7 )-7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) and PD 128907, two D3 receptor agonists whose in vivo selectivity has been a topic of considerable controversy. We demonstrate that both compounds inhibit locomotion under novel environmental conditions in wild-type (WT) mice, but are without measurable behavioral effect under identical conditions in D3 receptor knockout mice. Additionally, we demonstrate that at low, D3 selective doses, these compounds are without behavioral effect in both WT and D3 receptor knockout mice that have acclimated to the testing environment. These findings suggest that D3 receptor stimulation inhibits novelty-stimulated locomotion, and establish conditions for the use of 7-OH-DPAT and PD 128907 as D3 receptor agonists in vivo. Potential implications of these observations are discussed.

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Section: Novelty-stimulated Locomotion May Account For Divergent Findsupporting

confidence: 71%

7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment

Pritchard

Logue

Hayes

et al. 2003

Neuropsychopharmacol

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“…Rather, the augmented reduction in GABA after withdrawal from repeated cocaine may nonspecifically promote behavioral responding. Supporting a more general role for GABA transmission in the ventral pallidum in behavioral activation, intra-ventral pallidum administration of GABA antagonists promotes spontaneous locomotor activity and feeding in satiated rats (Austin and Kalivas, 1990;Stratford et al, 1999), and GABA agonists reduce novelty and psychostimulant-induced motor activity, as well as startle responses (Mogenson and Nielsen, 1983;Swerdlow et al, 1990;Hooks and Kalivas, 1995;McFarland and Kalivas, 2001). Indeed, the reduction in extracellular GABA in response to a cocaine challenge may be more a reflection of behavioral sensitization than reinstatement of drug seeking.…”

Section: Discussionmentioning

confidence: 99%

Cocaine-Induced Reinstatement Requires Endogenous Stimulation of μ-Opioid Receptors in the Ventral Pallidum

Tang¹,

McFarland²,

Cagle³

et al. 2005

J. Neurosci.

139

142

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The projection from the nucleus accumbens to the ventral pallidum regulates the reinstatement of cocaine seeking in rats extinguished from cocaine self-administration. This projection coexpresses GABA and enkephalin, posing a role for -opioid receptors in the ventral pallidum in mediating the reinstatement of cocaine seeking. Rats were extinguished from cocaine self-administration, and the reinstatement of active lever pressing by cocaine was blocked by intra-ventral pallidum administration of the receptor antagonist Cys-Tyr-DTrp-Arg-Thr-Pen-Thr-NH 2 (CTAP) (0.03-3.0 g). Conversely, stimulating receptors with morphine (1-30 g) in the ventral pallidum reinstated cocaine seeking. The ability of intra-ventral pallidum morphine to reinstate lever pressing was blocked by co-microinjection of the antagonist CTAP and was augmented by systemic cocaine administration. The reinstatement of cocaine seeking was associated with reduced extracellular GABA in the ventral pallidum, and the reduction in GABA was also prevented by blocking receptors with CTAP (10 M). Although immunoblotting revealed that neither the total tissue concentration nor the membrane insertion of receptors in the ventral pallidum was altered by withdrawal from cocaine, the capacity of morphine (0.01-10 M) to reduce ventral pallidum levels of extracellular GABA was augmented in rats extinguished from cocaine self-administration. These data are consistent with the reinstatement of cocaine seeking being modulated in part by coreleased enkephalin and GABA from the accumbens-ventral pallidal projection, a modulation that may involve the inhibition of GABA release by presynaptic receptors.

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“…In outbred Sprague-Dawley rats, manipulations that reduce the influence of DA on its receptors also reduce novelty responses. For example, local infusion of the DA receptor antagonist fluphenazine into the NAc blocks novelty-induced exploration but has no effect on the activity of habituated animals (Hooks and Kalivas 1995).…”

Section: Discussionmentioning

confidence: 99%

Inbred Lewis and Fischer 344 rat strains differ not only in novelty- and amphetamine-induced behaviors, but also in dopamine transporter activity in vivo

2007

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Inbred Lewis (LEW) and Fischer 344 (F344) rats are differentially sensitive to drugs of abuse, making them useful for studying addiction-related neural mechanisms. Here, we investigated whether strain differences in dopamine transporters (DATs) in dorsal striatum (dSTR) and/or nucleus accumbens (NAc) may help to explain their behavioral differences. The behavior of male LEW and F344 rats was assessed in an open-field arena during habituation to novelty and after an i.v. infusion of saline and/or 0.5 mg/kg d-amphetamine (AMPH). In vitro measures of DAT binding, protein and cellsurface expression, as well as in vitro and in vivo measures of function, were used to compare DATs in dSTR and NAc of these two strains. We found that LEW rats exhibited higher novelty-and AMPHinduced locomotion, but F344 rats exhibited greater AMPH-induced rearing and stereotypy. An initial habituation session with i.v. saline minimized the strain differences in AMPH-induced behaviors except that the more frequent AMPH-induced rearing in F344 rats persisted. Strain differences in DAT total protein and basal activity were also observed, with LEW rats having less protein and slower in vivo clearance of locally-applied DA in dSTR and NAc. AMPH inhibited in vivo DA clearance in dSTR and NAc of both strains, but to a greater extent in F344 rats. Taken together, the lower basal DAT function in LEW rats is consistent with their greater novelty-induced locomotor activation, whereas the greater inhibition of DA clearance by AMPH in F344 rats is consistent with their marked AMPH-induced rearing behavior.

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The role of mesoaccumbens-pallidal circuitry in novelty-induced behavioral activation

Cited by 168 publications

References 66 publications

7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment

7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment

Cocaine-Induced Reinstatement Requires Endogenous Stimulation of μ-Opioid Receptors in the Ventral Pallidum

Inbred Lewis and Fischer 344 rat strains differ not only in novelty- and amphetamine-induced behaviors, but also in dopamine transporter activity in vivo

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