The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus

Chernikov, Alexander Alexandrovich; Александрович, Черников Александр; Severina, Anastasia Sergeevna; Сергеевна, Северина Анастасия; Shamhalova, Minara Shamhalovna; Шамхаловна, Шамхалова Минара; Shestakova, Marina Vladimirovna; Владимировна, Шестакова Марина

doi:10.14341/7674

Cited by 13 publications

(12 citation statements)

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“…Currently, OS reactions associated with hyperglycemia in DM are considered in the context of the "metabolic memory" phenomenon, when the modification of biomolecules by ROS can lead to cellular dysfunctions a long time later after of DM manifestation [20]. Thus, newly identified DM1 and DM2large epidemiological studies showed that early and intensive interventions aimed at stabilizing hyperglycemia and risk factors associated with cardiovascular diseases prevent the onset and slow the progression of late chronic complications [34].…”

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

“…The main molecular mechanisms associated with OS in DM have been determined and they are associated with glucose and lipid metabolism [52]. Thus, several metabolic pathways that stimulate OS development under glycemic conditions are considered: glycolytic pathway, enhanced formation of advanced glycation end products (AGE), hexosamine pathway, activation of protein kinase C (PKC), polyol pathway, and deactivation of the insulin signaling pathway [20]. Under hyperglycemia conditions, excessive production of ROS during glycolysis reactions is observed.…”

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confidence: 99%

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Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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The review presents modern views about the role of oxidative stress reactions in the pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the analysis of experimental and clinical studies. The sources of increased ROS generation in diabetes are specified, including the main pathways of altered glucose metabolism, oxidative damage to pancreatic β-cells, and endothelial dysfunction. The relationship between oxidative stress, carbonyl stress, and inflammation is described. The significance of oxidative stress reactions associated with hyperglycemia is considered in the context of the “metabolic memory” phenomenon. The results of our studies demonstrated significant ethnic and age-related variability of the LPO—antioxidant defense system parameters in patients with diabetes mellitus, which should be considered during complex therapy of the disease. Numerous studies of the effectiveness of antioxidants in diabetes mellitus of both types convincingly proved that antioxidants should be a part of the therapeutic process. Modern therapeutic strategies in the treatment of diabetes mellitus are aimed at developing new methods of personalized antioxidant therapy, including ROS sources targeting combined with new ways of antioxidant delivery.

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Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

mentioning

confidence: 99%

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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“…The average level of HbA1c in the study group was 9.36% with a minimum value of 5.9%, a maximum of 14.1% (median -9.32). It is likely that the decrease in the concentration of sRAGE in patients with DM is due to an increase in RAGE due to hyperglycemia, as well as a violation of the cleavage of sRAGE from RAGE, which may be mediated by endogenous insulin deficiency and secondary insulin resistance [4]. The data obtained suggest that low sRAGE values in patients with DM mark the degree of activation of the RAGE system and reflect the individual risk of vascular pathology [5].…”

Section: Resultsmentioning

confidence: 99%

"Non-Enzymatic Glycation in the Assessment of Metabolic Compensation of Diabetes Mellitus in Children"

Taranushenko¹

2022

BJSTR

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“…Інші дослідження вказують на те, що при активному лікуванні хворих на ЦД 2 типу із дебюту хвороби (ретельний контроль глікемії в дебюті ЦД 2 типу) активізує «метаболічну пам'ять» -стан, при якому ускладнення ЦД 2 типу «за інерцією» не прогресують навіть в умовах декомпенсації вуглеводного обміну. Концепція «метаболічної пам'яті» передбачає необхідність досягнення максимально ефективного контролю глікемії вже при перших ознаках порушення вуглеводного обміну (наприклад, шляхом призначення комбінації ліків) [19][20][21][22]. Зважаючи на високий ризик розвитку побічних явищ на фоні інтенсивної цукрознижуючої терапії, необхідно бути надзвичайно обережними у виборі препаратів для початкової комбінованої терапії, беручи до уваги профіль їх побічних ефектів [23][24][25].…”

Section: практикуючому ендокринологуunclassified

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Didushko

2020

PEP

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In recent years, there is a tendency towards an increasing number of people living with diabetes mellitus. Among all patients with diabetes, more than 90 % have type 2 diabetes mellitus (T2DM). It is important that besides increased T2DM morbidity, the frequency of diabetic complications is increasing too. Clinical inertia is considered as one of the causes of increased macrovascular complications risk, and the positive «metabolic memory» in patients newly diagnosed with T2DM as an early predictor of diabetic complications. The concept of «metabolic memory» allows for the necessity of maximally effective controlling glycemia already at first signs of impaired carbohydrate metabolism (e. g. administering a drug combination). According to meta-analysis data of study with a relatively short observation period, combined therapy with metformin and DPP-4 inhibitors in the early stages is most effective and safe. Peculiar attention is paid in the article to a recently presented study, VERIFY. This is a five-year-long study of long-term results of the early combined therapy with vildagliptin and metformin. The study was conducted in 254 research sites of 34 countries with 2001 patients of different ethnic backgrounds with recently diagnosed T2DM who had not gotten therapy earlier (glycated hemoglobin (HbA1c) level was 6.5–7.5 %) or had gotten metformin for not longer than a month. The patients were divided into two groups: one group got monotherapy with metformin, the second one got metformin and vildagliptin combination straight away. The main parameter of the study was the time before unsuccessful starting therapy and the necessity to start insulin therapy. The results of the VERIFY study demonstrate unambiguously that the early combined therapy with vildagliptin and metformin ensures more significant and lasting long-term advantages for the patients. Nowadays recommended method of starting monotherapy with further intensification during the treatment of patients with T2DM is a less effective treatment strategy.

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The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus

Cited by 13 publications

References 59 publications

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

"Non-Enzymatic Glycation in the Assessment of Metabolic Compensation of Diabetes Mellitus in Children"

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