The Role of Metabolic Tumor Volume and Total Lesion Glycolysis on 18F-Fdg Pet/Ct in the Prognosis of Epithelial Ovarian Cancer

Lee, J.W.; Lee, S.M.; Kang, Won Jun; Lee, J.D.; Kim, Y.T.

doi:10.1093/annonc/mdu338.21

Cited by 2 publications

(5 citation statements)

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“…MTV and TLG were independent prognostic factors for disease progression and overall survival after cytoreductive surgery in patients with EOC 23,25 . In our study, MTV, TLG, metastatic TLG index, and metastatic MTV index were highly associated with OLNM.…”

Section: Discussionmentioning

confidence: 90%

“…Previous studies have investigated the predictive value of PET metabolic parameters in AEOC 25,27,37 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the challenge is to distinguish the patients with OLNM who should have a lymphadenectomy from the patient with "no suspect lymph nodes" who should not have lymphadenectomy. Previous studies have demonstrated that certain PET/CT parameters, such as standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), were signi cant prognostic factors for AEOC [21][22][23][24][25] . However, there was no study to evaluate the correlation between PET/CT-related parameters and LNM, especially OLNM.…”

Section: Introductionmentioning

confidence: 99%

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Predictive value of PET metabolic parameters for occult lymph node metastases in PET/CT defined node-negative patients with advanced epithelial ovarian cancer

Xue

Wang

2023

Preprint

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Accurate lymph node metastasis (LNM) prediction is crucial for patients with advanced epithelial ovarian cancer (AEOC) since it guides the decisions about lymphadenectomy. Many previous studies showed that occult lymph node metastasis was common in AEOC. The objective of our study is to quantitatively assess the probability of occult lymph node metastasis (OLNM) defined by 18F-Fluorodeoxyglucose (FDG) PET/CT in AEOC and explore relationship between ONNM and PET metabolic parameters. The patients with pathologically confirmed AEOC who underwent PET/CT for preoperative staging at our institute were reviewed. Univariate and multivariate analyses were performed to evaluate the predictive value of PET/CT-related metabolic parameters for OLNM. The result of our study showed metastatic TLG index had a better diagnostic performance than other PET/CT-related metabolic parameters. Two variables were independently and significantly associated with OLNM in multivariate analysis: metastatic TLG index and primary tumor location. The logistic model combining metastatic TLG index and primary tumor location might be a promising tool to effectively predict the individualized possibility of OLNM for AEOC patients.

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Section: Discussionmentioning

confidence: 90%

“…Previous studies have investigated the predictive value of PET metabolic parameters in AEOC 25,27,37 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictive value of PET metabolic parameters for occult lymph node metastases in PET/CT defined node-negative patients with advanced epithelial ovarian cancer

Xue

Wang

2023

Preprint

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“…The median [range] Eisenkop score on PET/CT scan and surgical findings were 5 [1][2][3][4][5][6][7][8][9][10][11][12][13] and 6 [2][3][4][5][6][7][8][9][10][11][12][13], respectively. PET/CT scans correctly predicted the Eisenkop score with high sensitivity (84.2%), specificity (87.0%), and accuracy (85.1%) (Table 2 and Figure 1A).…”

Section: Performance Of 18 F-fdg Pet/ct Scan For Preoperative Assessmentmentioning

confidence: 99%

“…18 F-FDG PET/CT has been an important molecular imaging modality for preoperative and therapeutic effect assessment in ovarian cancer for several decades. Previous studies have shown that these semi-quantitative parameters are associated with patient clinical characteristics and prognosis in ovarian cancer (7)(8)(9)(10)(11)(12)(13)(14). However, there is limited data showing diagnostic accuracy of PET/CT scans for peritoneal metastases in advanced ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of 18F-FDG PET/CT scan for peritoneal metastases in advanced ovarian cancer

Feng¹,

Liu²,

Ju³

et al. 2021

Quant Imaging Med Surg

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Background: To assess the diagnostic accuracy of 18 F-FDG PET/CT to determine the Eisenkop score and peritoneal cancer index (PCI) in correlation with surgical findings.Methods: Forty-three patients underwent preoperative 18 F-FDG PET/CT scan, followed by primary cytoreductive surgery for advanced ovarian cancer between September 2015 and February 2018. Clinical data were prospectively collected, including intraoperative assessment (with Eisenkop and PCI scores) and surgical results. The sensitivity, specificity, and accuracy were calculated at each anatomical site. The Eisenkop score, PCI score, and tumor volume of PET/CT scans were compared with surgical findings.Results: A total of 32 (74.4%) patients were diagnosed with stage III, and 11 (25.6%) patients were stage IV. Among these individuals, 19 (44.2%) patients had no residual disease after primary surgery. The median[range] Eisenkop score on PET/CT scans and surgical findings were 5 [1-13] and 6 [2-13], respectively.PET/CT scans correctly predicted the Eisenkop score with high sensitivity (84.2%), specificity (87.0%), and accuracy (85.1%). The diagnostic accuracy of PET/CT scans for PCI scores was lower (78.5%), with 72.7% sensitivity and 84.9% specificity. Preoperative PET/CT scans might underestimate tumor volume compared with surgical findings.Conclusions: 18 F-FDG PET/CT scans accurately predicted peritoneal metastases in advanced ovarian cancer before surgery using Eisenkop score.

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The Role of Metabolic Tumor Volume and Total Lesion Glycolysis on 18F-Fdg Pet/Ct in the Prognosis of Epithelial Ovarian Cancer

Cited by 2 publications

References 0 publications

Predictive value of PET metabolic parameters for occult lymph node metastases in PET/CT defined node-negative patients with advanced epithelial ovarian cancer

Predictive value of PET metabolic parameters for occult lymph node metastases in PET/CT defined node-negative patients with advanced epithelial ovarian cancer

Diagnostic accuracy of 18F-FDG PET/CT scan for peritoneal metastases in advanced ovarian cancer

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