2021
DOI: 10.3390/biom11081248
|View full text |Cite
|
Sign up to set email alerts
|

The Role of Methionine Residues in the Regulation of Liquid-Liquid Phase Separation

Abstract: Membraneless organelles are non-stoichiometric supramolecular structures in the micron scale. These structures can be quickly assembled/disassembled in a regulated fashion in response to specific stimuli. Membraneless organelles contribute to the spatiotemporal compartmentalization of the cell, and they are involved in diverse cellular processes often, but not exclusively, related to RNA metabolism. Liquid-liquid phase separation, a reversible event involving demixing into two distinct liquid phases, provides … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
9
0
6

Year Published

2022
2022
2024
2024

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 11 publications
(15 citation statements)
references
References 196 publications
(313 reference statements)
0
9
0
6
Order By: Relevance
“…The human proteome was surveyed in search of proteins that may participate in the regulation of LLPS by the redox status of the protein. To this end, we focused our attention on MR-PrLDs similar to those present in the yeast ataxin-2 and the human TDP-43 proteins [ 17 ]. Since direct sequence comparison via sequence alignment was not a feasible approach, we resorted to a definition of MR-PrLD that would be easy to handle computationally.…”
Section: Resultsmentioning
confidence: 99%
See 4 more Smart Citations
“…The human proteome was surveyed in search of proteins that may participate in the regulation of LLPS by the redox status of the protein. To this end, we focused our attention on MR-PrLDs similar to those present in the yeast ataxin-2 and the human TDP-43 proteins [ 17 ]. Since direct sequence comparison via sequence alignment was not a feasible approach, we resorted to a definition of MR-PrLD that would be easy to handle computationally.…”
Section: Resultsmentioning
confidence: 99%
“…LCRs and prion-like domains tend to be intrinsically disordered [ 17 ]. These protein regions fail to form a unique predominantly stable tertiary structure, which favors less compact conformations [ 43 ].…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations