The role of MHC class Ib-restricted T cells during infection

Anderson, Courtney; Brossay, Laurent

doi:10.1007/s00251-016-0932-z

Cited by 24 publications

(18 citation statements)

References 216 publications

(256 reference statements)

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“…Increasing evidence demonstrates that MHC-class-Ib-restricted T cells are capable of responding to many bacterial and viral pathogens ( Anderson and Brossay, 2016 ). Thus far, however, the non-classical T cell response to CMV has largely gone unappreciated.…”

Section: Discussionmentioning

confidence: 99%

“…Non-classical CD8 + T cells participate in the host defense against a number of bacterial and viral pathogens ( Anderson and Brossay, 2016 ). Evidence also suggests that HLA-E-restricted CD8 + T cells are present following HCMV infection ( Mazzarino et al, 2005 ; Pietra et al, 2003 ); however, their role during the immune response is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection

et al. 2019

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SUMMARY The role of non-classical T cells during viral infection remains poorly understood. Using the well-established murine model of CMV infection (MCMV) and mice deficient in MHC class Ia molecules, we found that non-classical CD8 + T cells robustly expand after MCMV challenge, become highly activated effectors, and are capable of forming durable memory. Interestingly, although these cells are restricted by MHC class Ib molecules, they respond similarly to conventional T cells. Remarkably, when acting as the sole component of the adaptive immune response, non-classical CD8 + T cells are sufficient to protect against MCMV-induced lethality. We also demonstrate that the MHC class Ib molecule Qa-1 (encoded by H2-T23 ) restricts a large, and critical, portion of this population. These findings reveal a potential adaptation of the host immune response to compensate for viral evasion of classical T cell immunity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection

et al. 2019

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“…In summary, copy number variations in both MHC class I and II genes appear to be common in fish. Null-allele variation in nonclassical MHC class I genes is particularly interesting because in mammals it is known that knockout of such genes can deplete T cell subpopulations that are restricted by their products [186], like for example MR1 and CD1d knockout cause depletions of MAIT cells [187] and NKT cells [188], respectively.…”

Section: Genomic Organization/haplotype Variationmentioning

confidence: 99%

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

Yamaguchi

Dijkstra

2019

Cells

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Fascinating about classical major histocompatibility complex (MHC) molecules is their polymorphism. The present study is a review and discussion of the fish MHC situation. The basic pattern of MHC variation in fish is similar to mammals, with MHC class I versus class II, and polymorphic classical versus nonpolymorphic nonclassical. However, in many or all teleost fishes, important differences with mammalian or human MHC were observed: (1) The allelic/haplotype diversification levels of classical MHC class I tend to be much higher than in mammals and involve structural positions within but also outside the peptide binding groove; (2) Teleost fish classical MHC class I and class II loci are not linked. The present article summarizes previous studies that performed quantitative trait loci (QTL) analysis for mapping differences in teleost fish disease resistance, and discusses them from MHC point of view. Overall, those QTL studies suggest the possible importance of genomic regions including classical MHC class II and nonclassical MHC class I genes, whereas similar observations were not made for the genomic regions with the highly diversified classical MHC class I alleles. It must be concluded that despite decades of knowing MHC polymorphism in jawed vertebrate species including fish, firm conclusions (as opposed to appealing hypotheses) on the reasons for MHC polymorphism cannot be made, and that the types of polymorphism observed in fish may not be explained by disease-resistance models alone.

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“…In summary, copy number variations in both MHC class I and II genes appear to be common in fish. Null-allele variation in nonclassical MHC class I genes is particularly interesting because in mammals it is known that knockout of such genes can deplete T cell subpopulations that are restricted by their products [144], like for example MR1 and CD1d knockout cause depletions of MAIT cells [145] and NKT cells [146], respectively.…”

Section: Genomic Organization / Haplotype Variationmentioning

confidence: 99%

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

Yamaguchi¹,

Dijkstra²

2019

Preprint

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The basic pattern of MHC variation in fish, with MHC class I versus class II, and polymorphic classical versus nonpolymorphic nonclassical, is similar in fish and mammals. Nevertheless, in many or all teleost fishes, important differences with mammalian or human MHC were observed: (1) The allelic/haplotype diversification levels of classical MHC class I genes tend to be much higher than in mammals; (2) Teleost fish classical MHC class I and class II loci are not linked. The present article summarizes previous studies that performed quantitative trait loci (QTL) analysis for mapping differences in teleost fish disease resistance, and discusses them from MHC point of view. Overall, those studies suggest the possible importance of genomic regions including classical MHC class II and nonclassical MHC class I genes, whereas similar observations were not made for the genomic regions with the highly diversified classical MHC class I alleles. The present study is a review and discussion of the fish MHC situation.

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The role of MHC class Ib-restricted T cells during infection

Cited by 24 publications

References 216 publications

Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection

Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

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