The role of microalbuminuria and insulin resistance as significant risk factors for white matter lesions in Japanese type 2 diabetic patients

Abstract

The results of this preliminary study indicate that the presence of WML was associated with the microalbuminuria and insulin resistance in these Japanese patients with type 2 DM; larger cohort studies are warranted to confirm these findings.

Microvascular Determinants of Cognitive Decline and Brain Volume Change in Elderly Patients with Type 2 Diabetes

“…c p < 0.001. cations and brain volumes or volume changes. This finding is in contrast with previous cross-sectional studies in patients with T2DM that reported diabetic retinopathy to be associated with cerebral atrophy and microalbuminuria with more severe WMH [10,13] . However, microvascular complications in our population were relatively mild, and cognitive deficits associated with these complications could possibly precede detectable structural changes with our brain volume measurements.…”

“…Indeed, previous studies in the general population, not specifically in the context of T2DM, observed associations between markers of microvascular disease (albuminuria, retinopathy) and cognitive decrements and brain abnormalities [3,4] . However, only few studies have reported on the association of microvascular complications with cognition and brain volumes in patients with T2DM [10][11][12][13] . A cross-sectional study in patients with T2DM found an association between cognitive status measured by the MMSE and microalbuminuria, but did not assess retinopathy or neuropathy [12] .…”

Hepatocyte growth factor is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients

“…In those studies [12][13][14], it was discussed that the predominant involvement of endothelial dysfunction was in the development of hyperhomocystenemia, microlabuminurian, abdominal visceral fat accumulation and WML. Taken together, it is possible that the presence of WML, insulin resistance and high HGF levels reinforce each other through mechanisms associated with endothelial dysfunction.…”

“…We have reported that WML is associated with insulin resistance in type 2 diabetic patients [12][13][14]. Recently, the relationships between the vascular risk factors and WML are demonstrated [15][16][17].…”

White matter lesions are associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in type 2 diabetes mellitus patients

“…We have recently reported that the presence of WML is associated with hyperhomocysteinemia, microalbuminuria, and insulin resistance in type 2 DM patients [34,35].…”