The role of microbiota in colorectal cancer

Khosravi, Azar Dokht; Seyed‐Mohammadi, Sakineh; Teimoori, Ali; Dezfuli, Aram Asarehzadegan

doi:10.1007/s12223-022-00978-1

Cited by 7 publications

(3 citation statements)

References 88 publications

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“…In addition, SCFAs produced by gut flora fermentation can regulate immune response, alleviate IBD and reduce the risk of colorectal cancer (CRC) ( Llewellyn et al, 2018 ). Two groups of researchers conducted animal experiments on CRC induced by azomethane (AOM)/DSS and found that a variety of intestinal commensal bacteria and their metabolites help promote the occurrence of CRC ( Sears and Garrett, 2014 ), they also found that gut flora imbalance (reduced microbial diversity) is one of the important factors leading to CRC ( Dokht et al, 2022 ). Luo et al (2018) extracting G. lucidum polysaccharides (GLPs) whose main component is β-1,3-glucan effectively prevents mice colon shortening and significantly reduces the relative abundance (RA) of cecal Oscillospira ; Guo et al (2021) water-soluble GLP extracted from peeled spores of G. lucidum reduced the relative abundance of some bacterial groups that are positively related to CRC carcinogenesis by inhibiting the TLR4/MyD88/NF-κB signaling pathway, and effectively improved the imbalance of gut flora in mice and increase the number of SCFAs.…”

Section: Effects Of Different Components Of Ganoderma Lucid...mentioning

confidence: 99%

Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases

Qin,

Fang,

Zhang

et al. 2024

Front. Microbiol.

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Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a precious large fungus with medicinal and nutritional health care values. Among them, polysaccharides, triterpenoids, oligosaccharides, trace elements, etc. are important bioactive components in G. lucidum. These bioactive components will have an impact on gut flora, thus alleviating diseases such as hyperglycemia, hyperlipidemia and obesity caused by gut flora disorder. While numerous studies have demonstrated the ability of G. lucidum and its active components to regulate gut flora, a systematic review of this mechanism is currently lacking. The purpose of this paper is to summarize the regulatory effects of G. lucidum and its active components on gut flora in cardiovascular, gastrointestinal and renal metabolic diseases, and summarize the research progress of G. lucidum active components in improving related diseases by regulating gut flora. Additionally, review delves into the principle by which G. lucidum and its active components can treat or assist treat diseases by regulating gut flora. The research progress of G. lucidum in intestinal tract and its potential in medicine, health food and clinical application were fully explored for researchers.

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Section: Effects Of Different Components Of Ganoderma Lucid...mentioning

confidence: 99%

Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases

Qin,

Fang,

Zhang

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Having shown that the time of CRC tumor formation affected the therapeutic effect of OVV-gp33, the underlying mechanism was then investigated. Previous studies showed that the intestinal microbiota plays important roles in the development of CRC and microbiota abundance is altered in CRC patients [22,23]. We next investigated the characteristics of the intestinal flora based on fecal sample 16S rDNA sequencing.…”

Section: Intestinal Microbiota Influenced the Therapeutic Effect Of O...mentioning

confidence: 99%

Intestinal microbiota modulates the anti-tumor effect of oncolytic virus vaccine in colorectal cancer

Chen

Wang

Qin

et al. 2023

Preprint

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BackgroundImmunotherapy such as oncolytic virus has become a powerful cancer treatment but only a part of cancer patients can benefit from it, especially to advanced-stage cancer patients are required new therapeutic strategies to facilitate extended survival. Intestinal microbiota may contribute to colorectal cancer (CRC) carcinogenesis and response to immunotherapy. However, whether and how the modulating effect of intestinal microbiota on oncolytic virus vaccine (OVV) in CRC remains to be investigated.MethodsWe generated a MC38-gp33 CRC mouse model and treated with OVV-gp33 in early- and advanced-stages. Probiotics, fecal microbiota transplantation (FMT) and antibiotics (ABX) were treated to regulate the microbial composition of CRC mice of advanced stage. The tumor growth rate and survival time of mice were recorded. 16S rDNA sequencing analyzed the microbial composition and flow cytometry detected the T cells subsets activity.ResultsOVV-gp33 treatment led to inhibited tumor growth and prolonged survival in the early stage of CRC but did not have a significant effect on the advanced stage of CRC. Moreover, 16S rDNA sequence analysis and flow cytometry showed significant differences in intestinal microbiota composition, microbial metabolites and T-cell subsets in early- and advanced-stage CRC. Probiotic and FMT treatment significantly enhanced the antitumor effect of OVV in advanced stage of CRC with an increased abundance of activated CD8+T cells and a decreased ratio of Treg cells, while depletion of the microbiota by ABX eliminated the antitumor activity of OVV with decreased CD8+T-cell activation and upregulated Treg cells.ConclusionsThese results indicate that intestinal microbiota and microbial metabolites play an important role in the OVV antitumor effect in CRC, furthermore, altering the intestinal microbiota composition can modulate the antitumor and immunomodulatory effect of OVV in CRC.

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“…The equilibrium of gut bacteria serves a key role in host physiological activities and dysbiosis of gut microbes can lead to conditions such as inflammatory bowel disease (IBD), irritable bowel syndrome, obesity, type 2 diabetes ( 5 ). The role of the microbiome in the development and progression of CRC has recently received increased attention; however, how the microbiota determines cancer susceptibility and progression remains unknown ( 6 , 7 ). Previous studies have investigated the connections between gut microbiota and CRC, in addition to the involvement of the microbiome in the development of CRC ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Calorie restriction remodels gut microbiota and suppresses tumorigenesis of colorectal cancer in mice

et al. 2022

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Colorectal cancer (CRC) is one of the most common cancers worldwide and the consumption of a high-calorie diet is one of its risk factors. Calorie restriction (CR) slows tumor growth in a variety of cancers, including colorectal cancer; however, the mechanism behind this remains unknown. In the present study, CR effectively reduced the tumor volume and weight in a xenograft BALB/c male nude mouse model. In addition, tumor immunohistochemistry revealed that the CR group had significantly higher expression of Bax (P<0.001) and significantly lower levels of Bcl2 (P<0.0001) and Ki67 (P<0.001) compared with control group. Furthermore, data from 16S ribosomal (r)RNA sequencing implied that CR was able to reprogram the microbiota structure, characterized by increased Lactobacillus constituent ratio (P<0.05), with amelioration of microbial dysbiosis caused by CRC. Further receiver operating characteristic curves demonstrated that the bacteria Bacteroides [area under the curve (AUC)=0.800], Lactobacillus (AUC= 0.760) and Roseburia (AUC= 0.720) served key roles in suppression of CRC in the mouse model. The functional prediction of intestinal flora indicated 'cyanoamino acid metabolism' (P<0.01), 'replication initiation protein REP (rolling circle plasmid replication)' (P<0.01), 'tRNA G10 N-methylase Trm11' (P<0.01) and 'uncharacterized protein with cyclophilin fold, contains DUF369 domain' (P<0.05) were downregulated in CR group. These findings implied that CR suppressed CRC in mice and altered the gut microbiota.

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The role of microbiota in colorectal cancer

Cited by 7 publications

References 88 publications

Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases

Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases

Intestinal microbiota modulates the anti-tumor effect of oncolytic virus vaccine in colorectal cancer

Calorie restriction remodels gut microbiota and suppresses tumorigenesis of colorectal cancer in mice

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