The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

Ferrari, Filippo Alberto; Magni, Francesca; Bosco, Mariachiara; Biancotto, Giulia; Zorzato, Pier Carlo; Laganà, Antonio Simone; Chiàntera, Vito; Raffaelli, Ricciarda; Franchi, Massimo Piergiuseppe; Uccella, Stefano; Garzon, Simone

doi:10.3390/healthcare11111652

Cited by 4 publications

(2 citation statements)

References 108 publications

(209 reference statements)

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“…The regression rates were significantly lower in non-pregnant women [ 5 – 7 ]. Diet and nutrition are modifiable risk factors for several cancers and the regression rate of CIN is demonstrated to be influenced by several variables, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients have demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of CIN [ 8 ].…”

Section: Natural Course Of Cervical Intraepithelial Neoplasia In Preg...mentioning

confidence: 99%

Screening for Cervical Cancer in Pregnancy

Kumari

2023

Oncol Rev.

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Cervical cancer remains a leading cause of cancer related morbidity and mortality in low/low-middle income countries. Lack of screening is the leading cause of cases being diagnosed in advanced stages and screening is still opportunistic in a majority of these countries. Hospital visits during pregnancy provides a window of opportunity to screen these susceptible women and reduce the burden of disease. Screening women during pregnancy is not practiced widely due to concerns of pregnancy loss, bleeding and a lack of clear information among patients as well as healthcare professionals.

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Section: Natural Course Of Cervical Intraepithelial Neoplasia In Preg...mentioning

confidence: 99%

Screening for Cervical Cancer in Pregnancy

Kumari

2023

Oncol Rev.

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“…Strategies for preventing the development of gynecologic cancers include regular gynecologic check-ups, human papillomavirus (HPV) vaccination or physical activity and a healthy diet [2,3]. In the past two decades, many publications have focused attention on the role of micronutrients in the prevention of gynecologic malignancies [4][5][6]. Extensive meta-analyses have shown that daily supplementation with vitamin A and D3 can reduce the incidence of ovarian cancer [7][8][9], as well as mortality from malignant cancer by up to 12% [9].…”

Section: Introductionmentioning

confidence: 99%

Vitamins in Gynecologic Malignancies

Wierzbowska,

Olszowski,

Chlubek

et al. 2024

Nutrients

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The combination of vitamin A and D derivatives with classical chemotherapeutic treatments results in more satisfactory outcomes. The use of drug combinations, such as 9cUAB130 with carboplatin and cisplatin with TAC-101, shows enhanced cytotoxic effects and reductions in ovarian tumor volume compared to single-drug treatments. Combining cisplatin with calcitriol and progesterone increases VDR expression, potentially enhancing the effectiveness of anticancer therapy in ovarian cancer. The effectiveness of vitamin derivatives in anticancer treatment may vary depending on the characteristics of the tumor and the cell line from which it originated. An increase in thiamine intake of one unit is associated with an 18% decrease in HPV infection. Higher intake of vitamin C by 50 mg/day is linked to a lower risk of cervical neoplasia. Beta-carotene, vitamin C, and vitamin E are associated with risk reductions of 12%, 15%, and 9% in endometrial cancer, respectively. A balanced daily intake of vitamins is important, as both deficiency and excess can influence cancer development. It has been observed that there is a U-shaped relationship between group B vitamins and metabolic markers and clinical outcomes.

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Retinoids: Molecular Aspects and Treatment in Premalignant Lesions and Cervical Cancer

Cortés-Malagón,

Gariglio,

Sierra-Martínez

et al. 2024

Cancer Control

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Persistent infection with high-risk human papillomavirus remains the primary factor associated with the progression of cervical squamous intraepithelial lesions and the development of cervical cancer. Nevertheless, a combination of factors, including genetic predisposition, immune response, hormonal influences, and nutritional status, contribute synergistically to the development of cervical cancer. Among the various factors involved in the pathogenesis and therapy of cervical cancer, retinoids have gained considerable attention due to their multifaceted roles in different cellular processes. This review investigates defects within the vitamin A metabolism pathway and their correlation with cervical cancer. Additionally, it integrates epidemiological and experimental findings to discuss the potential utility of retinoid-based therapies, either alone or combined with other therapies, as agents against premalignant lesions and cervical cancer.

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The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

Cited by 4 publications

References 108 publications

Screening for Cervical Cancer in Pregnancy

Screening for Cervical Cancer in Pregnancy

Vitamins in Gynecologic Malignancies

Retinoids: Molecular Aspects and Treatment in Premalignant Lesions and Cervical Cancer

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