The role of microplate selection and assay design in the application of automation and robotics

Kolb, Alfred J.

doi:10.1016/0169-7439(94)90052-3

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…To date, microwell experimentation has mainly been applied to high throughput drug discovery (Delvin, 1997;Lamsa et al, 2004;Wegener et al, 2003) and the routine performance of laboratory assays (Kolb, 1994;Wang et al, 2003). Here the focus has been on understanding the reliability and operation of the liquid handling robots used to perform experiments (Astle and Akowitz, 1996;Berg et al, 2001;Stevens et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Quantification and prediction of jet macro-mixing times in static microwell plates

Nealon

O’Kennedy

Titchener‐Hooker

et al. 2006

Chemical Engineering Science

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Section: Introductionmentioning

confidence: 99%

Quantification and prediction of jet macro-mixing times in static microwell plates

Nealon

O’Kennedy

Titchener‐Hooker

et al. 2006

Chemical Engineering Science

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Automation of metabolic stability studies in microsomes, cytosol and plasma using a 215 Gilson liquid handler

Linget¹,

Vignaud²

1999

Journal of Pharmaceutical and Biomedical Analysis

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Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors

Abbasi,

Hu,

Zhang

et al. 2024

Bioengineering

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Optical biosensors have emerged as a powerful tool in analytical biochemistry, offering high sensitivity and specificity in the detection of various biomolecules. This article explores the advancements in the integration of optical biosensors with microfluidic technologies, creating lab-on-a-chip (LOC) platforms that enable rapid, efficient, and miniaturized analysis at the point of need. These LOC platforms leverage optical phenomena such as chemiluminescence and electrochemiluminescence to achieve real-time detection and quantification of analytes, making them ideal for applications in medical diagnostics, environmental monitoring, and food safety. Various optical detectors used for detecting chemiluminescence are reviewed, including single-point detectors such as photomultiplier tubes (PMT) and avalanche photodiodes (APD), and pixelated detectors such as charge-coupled devices (CCD) and complementary metal–oxide–semiconductor (CMOS) sensors. A significant advancement discussed in this review is the integration of optical biosensors with pixelated image sensors, particularly CMOS image sensors. These sensors provide numerous advantages over traditional single-point detectors, including high-resolution imaging, spatially resolved measurements, and the ability to simultaneously detect multiple analytes. Their compact size, low power consumption, and cost-effectiveness further enhance their suitability for portable and point-of-care diagnostic devices. In the future, the integration of machine learning algorithms with these technologies promises to enhance data analysis and interpretation, driving the development of more sophisticated, efficient, and accessible diagnostic tools for diverse applications.

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The role of microplate selection and assay design in the application of automation and robotics

Cited by 3 publications

References 5 publications

Quantification and prediction of jet macro-mixing times in static microwell plates

Quantification and prediction of jet macro-mixing times in static microwell plates

Automation of metabolic stability studies in microsomes, cytosol and plasma using a 215 Gilson liquid handler

Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors

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