The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer

Mahjoor, Mohamad; Afkhami, Hamed; Najafi, Mohammad; Nasr, Atieh; Khorrami, Samaneh

doi:10.1007/s00432-022-04123-w

Cited by 16 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to affecting the consumption of the body by inflammation 22 – 24 , it also regulates epithelial mesenchymal transition in tumors 25 – 27 . Althoug, the miR-30c expression disorders play a role in activating and regulating various signaling pathways for tumorigenesis, invasion and metastasis in digestive organs 28 – 30 the role of miR-30c in IBD, especially UC, has rarely been reported so far. In this study, DSS-induced colitis in mice was used to investigate the effect of low miR-30c expression on colon of mice.…”

Section: Discussionmentioning

confidence: 99%

miR-30c affects the pathogenesis of ulcerative colitis by regulating target gene VIP

Dong,

Zhan,

Yang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

MicroRNAs play a crucial role in regulating the epithelial barrier and immune response, which are implicated in the pathogenesis of ulcerative colitis (UC). This study aimed to investigate the role and molecular mechanism of miR-30c in the pathogenesis of UC using a dextran sulfate sodium salt (DSS)-induced colitis model, which is similar to ulcerative colitis. Wild-type (WT) and miR-30c knockout (KO) mice were assigned to either control or DSS-treated groups to evaluate the influence of aberrant miR-30c expression on UC pathogenesis. The disease activity index, inflammatory factors, and the extent of pathological and histological damage in colon tissues were analyzed. The effect of miR-30c on vasoactive intestinal peptide (VIP) gene expression was validated through luciferase reporter assay, qRT-PCR, Western blotting, and immunohistochemistry. The results showed that miR-30c KO mice with DSS-induced colitis model showed more severe phenotypes: significantly higher disease activity indices, significant body weight loss, reduced length of the colon of mice, increased number of aberrant crypt structures, reduced mucus secretion, and significant differences in inflammatory factors. These findings suggested that the absence of miR-30c might promote DSS-induced colitis, and the targe-regulatory effect of miR-30c on VIP might play an important role in the development of colitis.

show abstract

Section: Discussionmentioning

confidence: 99%

miR-30c affects the pathogenesis of ulcerative colitis by regulating target gene VIP

Dong,

Zhan,

Yang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…SCs are described as undifferentiated cells that are able to proliferate and transform into various types of mature cells that form different tissues and organs in the body ( Bahmad et al, 2021 ; Mahjoor et al, 2022 ). SCs are found in embryos and adult cells, and with each step of specialization, their differentiation potency decreases ( Zakrzewski et al, 2019 ; Mahjoor et al, 2021 ).…”

Section: Prefaced Of Stem Cells Function In Wound Repair Processmentioning

confidence: 99%

Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight

Mahmoudvand

Rouzbahani²,

Razavi³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Diabetic foot ulcer (DFU) is considered the most catastrophic complication of diabetes mellitus (DM), leading to repeated hospitalizations, infection, gangrene, and finally amputation of the limb. In patients suffering from diabetes mellitus, the wound-healing process is impaired due to various factors such as endothelial dysfunction and synthesis of advanced glycation end-products, hence, conventional therapeutic interventions might not be effective. With increasing therapeutic applications of mesenchymal stem cells (MSCs) in recent years, their potential as a method for improving the wound-healing process has gained remarkable attention. In this field, mesenchymal stem cells exert their beneficial effects through immunomodulation, differentiation into the essential cells at the site of ulcers, and promoting angiogenesis, among others. In this article, we review cellular and molecular pathways through which mesenchymal stem cell therapy reinforces the healing process in non-healing Diabetic foot ulcers.

show abstract

“…Gastrointestinal (GI) malignancies constitute approximately one-third of all newly diagnosed cancer cases globally and pose a significant public health challenge. Colorectal cancer (CRC), Gastric cancer (GC), liver cancer, and esophageal cancer are the most commonly observed GI malignancies across the globe ( 1 , 2 ). Since GI malignancies have been on the rise over the past 5 to 10 years, there is a severe health risk to people due to this trend.…”

Section: Introductionmentioning

confidence: 99%

The role of microbiomes in gastrointestinal cancers: new insights

Yarahmadi,

Afkhami

2024

Front. Oncol.

Self Cite

View full text Add to dashboard Cite

Gastrointestinal (GI) cancers constitute more than 33% of new cancer cases worldwide and pose a considerable burden on public health. There exists a growing body of evidence that has systematically recorded an upward trajectory in GI malignancies within the last 5 to 10 years, thus presenting a formidable menace to the health of the human population. The perturbations in GI microbiota may have a noteworthy influence on the advancement of GI cancers; however, the precise mechanisms behind this association are still not comprehensively understood. Some bacteria have been observed to support cancer development, while others seem to provide a safeguard against it. Recent studies have indicated that alterations in the composition and abundance of microbiomes could be associated with the progression of various GI cancers, such as colorectal, gastric, hepatic, and esophageal cancers. Within this comprehensive analysis, we examine the significance of microbiomes, particularly those located in the intestines, in GI cancers. Furthermore, we explore the impact of microbiomes on various treatment modalities for GI cancer, including chemotherapy, immunotherapy, and radiotherapy. Additionally, we delve into the intricate mechanisms through which intestinal microbes influence the efficacy of GI cancer treatments.

show abstract

The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer

Cited by 16 publications

References 42 publications

miR-30c affects the pathogenesis of ulcerative colitis by regulating target gene VIP

miR-30c affects the pathogenesis of ulcerative colitis by regulating target gene VIP

Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight

The role of microbiomes in gastrointestinal cancers: new insights

Contact Info

Product

Resources

About