The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells

Chao, Chuan-Chuan; Kan, Daphne; Lu, Kuo‐Shyan; Chien, Chung‐Liang

doi:10.1016/j.scr.2015.01.008

Cited by 14 publications

(12 citation statements)

References 53 publications

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“…These regulatory networks result in a refined molecular response system that enables proper cellular proliferation, differentiation and function. miR‐30c, an abundant miRNA in brain, has been reported to enable the proliferation of C6 glioma cells and simultaneously inhibit their differentiation . In our study, using the methods of SVZ microdomain intervention, morphological analysis, cell‐cycle analysis and cell‐proliferation assays, miR‐30c was demonstrated to stimulate the proliferation and inhibit the differentiation of stem cells in the adult SVZ.…”

Section: Discussionmentioning

confidence: 70%

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miR‐30c and semaphorin 3A determine adult neurogenesis by regulating proliferation and differentiation of stem cells in the subventricular zones of mouse

Sun

Shao

2016

Cell Proliferation

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Section: Discussionmentioning

confidence: 70%

“…Their expressions changes during development, and they are abundant in specific tissues, suggesting that they play their roles at specific stages. miR‐30c is abundant in brain and is known to be critical for the renewal of glioma cells in vitro .…”

Section: Introductionmentioning

confidence: 99%

miR‐30c and semaphorin 3A determine adult neurogenesis by regulating proliferation and differentiation of stem cells in the subventricular zones of mouse

Sun

Shao

2016

Cell Proliferation

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“…Intriguingly, miR-30 has been reported to inhibit the self-renewal and metastasis of breast TICs, 17 repress the stem cell and cancer phenotypes via targeting LIN28, 18 and play a regulatory role in self-renewal and neural differentiation in glioma cells. 19 However, the exact role of miR-30 in regulating the biological behavior of LTICs remains unclear.…”

Section: Micrornas (Mirnas) Are a Class Of Conserved Small Non-codingmentioning

confidence: 99%

miR-30 Family Reduction Maintains Self-Renewal and Promotes Tumorigenesis in NSCLC-Initiating Cells by Targeting Oncogene TM4SF1

Zhong

et al. 2018

Molecular Therapy

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Increasing evidence indicates that tumor-initiating cells (TICs) are responsible for the occurrence, development, recurrence, and development of the drug resistance of cancer. MicroRNA (miRNA) plays a significant functional role by directly regulating targets of TIC-triggered non-small-cell lung cancer (NSCLC), but little is known about the function of the miR-30 family in TICs. In this study, we found the miR-30 family to be downregulated during the spheroid formation of NSCLC cells, and patients with lower miR-30a/c expression had shorter overall survival (OS) and progression-free survival (PFS). Moreover, transmembrane 4 super family member 1 (TM4SF1) was confirmed to be a direct target of miR-30a/c. Concomitant low expression of miR-30a/c and high expression of TM4SF1 correlated with a shorter median OS and PFS in NSCLC patients. miR-30a/c significantly inhibited stem-like characteristics in vitro and in vivo via suppression of its target gene TM4SF1, and then it inhibited the activity of the mTOR/ AKT-signaling pathway. Thus, our data provide the first evidence that TM4SF1 is a direct target of miR-30a/c and miR-30a/c inhibits the stemness and proliferation of NSCLC cells by targeting TM4SF1, suggesting that miR-30a/c and TM4SF1 may be useful as tumor biomarkers for the diagnosis and treatment of NSCLC patients.

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“…miR-30c is an abundant miRNA in the brain. It has been confirmed to be the regulator of self-renewal and differentiation of glioma cells in vitro (Chao et al, 2015 ).…”

Section: Introductionmentioning

confidence: 96%

Altered Morphologies and Functions of the Olfactory Bulb and Hippocampus Induced by miR-30c

Sun

Davies

et al. 2016

Front. Neurosci.

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Adult neurogenesis is considered to contribute to a certain degree of plasticity for the brain. However, the effects of adult-born neurons on the brain are still largely unknown. Here, we specifically altered the expression of miR-30c in the subventricular zone (SVZ) and dentate gyrus (DG) by stereotaxic injection with their respective up- and down-regulated lentiviruses. Results showed an increased level of miR-30c enhanced adult neurogenesis by prompting cell-cycles of stem cells, whereas down-regulated miR-30c led to the opposite results. When these effects of miR-30c lasted for 3 months, we detected significant morphological changes in the olfactory bulb (OB) and lineage alteration in the hippocampus. Tests of olfactory sensitivity and associative and spatial memory showed that a certain amount of adult-born neurons are essential for the normal functions of the OB and hippocampus, but there also exist redundant newborn neurons that do not further improve the functioning of these areas. Our study revealed the interactions between miRNA, adult neurogenesis, brain morphology and function, and this provides a novel insight into understanding the role of newborn neurons in the adult brain.

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The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells

Abstract: Our findings suggest that miRNA-30c could play a regulatory role in self-renewal and neural differentiation in C6 glioma cells.

Cited by 14 publications

References 53 publications

miR‐30c and semaphorin 3A determine adult neurogenesis by regulating proliferation and differentiation of stem cells in the subventricular zones of mouse

miR‐30c and semaphorin 3A determine adult neurogenesis by regulating proliferation and differentiation of stem cells in the subventricular zones of mouse

miR-30 Family Reduction Maintains Self-Renewal and Promotes Tumorigenesis in NSCLC-Initiating Cells by Targeting Oncogene TM4SF1

Altered Morphologies and Functions of the Olfactory Bulb and Hippocampus Induced by miR-30c

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