The role of microRNA miR223 in immune adaptation for pregnancy and fetal-placental development

Schjenken, John E.; Hewson, Laura J; Zhang, Bihong; Robertson, Sarah A.

doi:10.1016/j.placenta.2015.07.212

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, contact with either the plasma and/or sperm fraction of seminal fluid may cause female reproductive tract cells to induce miRNAs. Indeed, recent experiments in female mice with a null mutation in miR‐223 support this hypothesis (Schjenken, Hewson, Zhang, & Robertson, ). A second plausible mechanism involves delivery of male miRNAs to female reproductive tract cells by sperm and/or seminal plasma microvesicles (prostasomes) (Tompkins et al, ) (Figure ).…”

Section: Reproductive Tract Mirna Expression and Immune Adaptation Fomentioning

confidence: 90%

MicroRNA regulation of immune events at conception

Robertson

Zhang

Chan

et al. 2017

Molecular Reproduction Devel

Self Cite

View full text Add to dashboard Cite

The reproductive tract environment at conception programs the developmental trajectory of the embryo, sets the course of pregnancy, and impacts offspring phenotype and health. Despite the fundamental importance of this stage of reproduction, the rate-limiting regulatory mechanisms operating locally to control fertility and fecundity are incompletely understood. Emerging studies highlight roles for microRNAs (miRNAs) in regulating reproductive and developmental processes and in modulating the quality and strength of the female immune response. Since endometrial receptivity and robust placentation require specific adaptation of the immune response, we hypothesize that miRNAs participate in establishing pregnancy through effects on key gene networks in immune cells. Our recent studies investigated miRNAs that are induced in the peri-conception environment, focusing on miRNAs that have immune-regulatory roles-particularly miR-223, miR-155, and miR-146a. Genetic mouse models deficient in individual miRNAs are proving informative in defining roles for these miRNAs in the generation and stabilization of regulatory T cells (Treg cells) that confer adaptive immune tolerance. Overlapping and redundant functions between miRNAs that target multiple genes, combined with multiple miRNAs targeting individual genes, indicate complex and sensitive regulatory networks. Although to date most data on miRNA regulation of reproductive events are from mice, conserved functions of miRNAs across species imply similar biological pathways operate in all mammals. Understanding the regulation and roles of miRNAs in the peri-conception immune response will advance our knowledge of how environmental determinants act at conception, and could have practical applications for animal breeding as well as human fertility.

show abstract

Section: Reproductive Tract Mirna Expression and Immune Adaptation Fomentioning

confidence: 90%

MicroRNA regulation of immune events at conception

Robertson

Zhang

Chan

et al. 2017

Molecular Reproduction Devel

Self Cite

View full text Add to dashboard Cite

show abstract

Systematic Review of Micro-RNA Expression in Pre-Eclampsia Identifies a Number of Common Pathways Associated with the Disease

et al. 2016

View full text Add to dashboard Cite

BackgroundPre-eclampsia (PE) is a complex, multi-systemic condition of pregnancy which greatly impacts maternal and perinatal morbidity and mortality. MicroRNAs (miRs) are differentially expressed in PE and may be important in helping to understand the condition and its pathogenesis.MethodsCase-control studies investigating expression of miRs in PE were collected through a systematic literature search. Data was extracted and compared from 58 studies to identify the most promising miRs associated with PE pathogenesis and identify areas of methodology which could account for often conflicting results.ResultsSome of the most frequently differentially expressed miRs in PE include miR-210, miR-223 and miR-126/126* which associate strongly with the etiological domains of hypoxia, immunology and angiogenesis. Members of the miR-515 family belonging to the imprinted chromosome 19 miR cluster with putative roles in trophoblast invasion were also found to be differentially expressed. Certain miRs appear to associate with more severe forms of PE such as miR-210 and the immune-related miR-181a and miR-15 families. Patterns of miR expression may help pinpoint key pathways (e.g. IL-6/miR-223/STAT3) and aid in untangling the heterogeneous nature of PE. The detectable presence of many PE-associated miRs in antenatal circulatory samples suggests their usefulness as predictive biomarkers. Further progress in ascertaining the clinical value of miRs and in understanding how they might contribute to pathogenesis is predicated upon resolving current methodological challenges in studies. These include differences in diagnostic criteria, cohort characteristics, sampling technique, RNA isolation and platform-dependent variation in miR profiling.ConclusionReviewing studies of PE-associated miRs has revealed their potential as informants of underlying target genes and pathways relating to PE pathogenesis. However, the incongruity in results across current studies hampers their capacity to be useful biomarkers of the condition.

show abstract

The role of microRNA miR223 in immune adaptation for pregnancy and fetal-placental development

Cited by 2 publications

References 0 publications

MicroRNA regulation of immune events at conception

MicroRNA regulation of immune events at conception

Systematic Review of Micro-RNA Expression in Pre-Eclampsia Identifies a Number of Common Pathways Associated with the Disease

Contact Info

Product

Resources

About