The role of microRNAs in prostate cancer migration, invasion, and metastasis

Aghdam, Shirin Golabi; Ebrazeh, Mehrdad; Hemmatzadeh, Maryam; Seyfizadeh, Nayer; Shabgah, Arezoo Gowhari; Azizi, Gholamreza; Ebrahimi, Negin; Babaie, Farhad; Mohammadi, Hamed

doi:10.1002/jcp.27948

Cited by 46 publications

(33 citation statements)

References 163 publications

(275 reference statements)

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“…No significant correlations for pairs of clinicopathological characteristics (PSA/age, PSA/Gleason score, age/Gleason score) were observed, which confirms results of many authors [74,75] and indicates the need to look for new biomarkers to facilitate the diagnosis of prostate cancer. Interestingly, only for miR-93, miR-182 and miR-375 associations between expression levels and Gleason score were observed [33,35,76].…”

Section: Discussionsupporting

confidence: 81%

MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer

Ciszkowicz

Porzycki

Semik

et al. 2020

IJMS

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Dysregulation of miRNAs has a fundamental role in the initiation, development and progression of prostate cancer (PCa). The potential of miRNA in gene therapy and diagnostic applications is well documented. To further improve miRNAs’ ability to distinguish between PCa and benign prostatic hyperplasia (BPH) patients, nine miRNA (-21, -27b, -93, -141, -205, -221, -182, -375 and let-7a) with the highest reported differentiation power were chosen and for the first time used in comparative studies of serum and prostate tissue samples. Spearman correlations and response operating characteristic (ROC) analyses were applied to assess the capability of the miRNAs present in serum to discriminate between PCa and BPH patients. The present study clearly demonstrates that miR-93 and miR-375 could be taken into consideration as single blood-based non-invasive molecules to distinguish PCa from BPH patients. We indicate that these two miRNAs have six common, PCa-related, target genes (CCND2, MAP3K2, MXI1, PAFAH1B1, YOD1, ZFYVE26) that share the molecular function of protein binding (GO:0005515 term). A high diagnostic value of the new serum derived miR-182 (AUC = 0.881, 95% confidence interval, CI = 0.816–0.946, p < 0.0001, sensitivity and specificity were 85% and 79%, respectively) is also described.

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Section: Discussionsupporting

confidence: 81%

MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer

Ciszkowicz

Porzycki

Semik

et al. 2020

IJMS

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“…5 Several research studies have revealed an enhanced prognosis with tumor-associated tissue eosinophilia and eosinophil degranulation indications in many types of solid tumors, such as esophageal cell and oral squamous carcinoma, 137,138 penile cancer, 139 colon tumors, 140 bladder carcinoma, laryngeal carcinoma, pulmonary adenocarcinoma, 141 nasopharyngeal carcinoma 142 and prostate cancer. 143,144 A further detailed analysis has shown that eosinophil trafficking is related to ILC2s and is regulated via the constitutive eotaxin-1 expression and IL-5 driven ILC2 circadian expression. 145 Additionally, high levels of IL-33 and IL-4, which are prototypic ILC2-type cytokines, suggesting poor prognosis in patients with CRC 146,147 (Table 1).…”

Section: Ilcs and Solid Tumorsmentioning

confidence: 99%

Progression or suppression: Two sides of the innate lymphoid cells in cancer

Hosseini

Sharafkandi

Seyfizadeh

et al. 2019

J of Cellular Biochemistry

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Innate lymphoid cells (ILCs) as key players in innate immunity have been shown to be significantly associated with inflammation, lymphoid neogenesis, tissue remodeling, mucosal immunity and lately have been considered a remarkable nominee for either tumor‐promoting or tumor‐inhibiting functions. This dual role of ILCs, which is driven by intrinsic and extrinsic factors like plasticity of ILCs and the tumor microenvironment, respectively, has aroused interest in ILCs subsets in past decade. So far, numerous studies in the cancer field have revealed ILCs to be key players in the initiation, progression and inhibition of tumors, therefore providing valuable insights into therapeutic approaches to utilize the immune system against cancer. Herein, the most recent achievements regarding ILCs subsets including new classifications, their transcription factors, markers, cytokine release and mechanisms that led to either progression or inhibition of many tumors have been evaluated. Additionally, the available data regarding ILCs in most prevalent cancers and new therapeutic approaches are summarized.

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“…The aberrant expression of microRNAs leads to various cancers [6,7]. MicroRNAs regulate the development of cancers, such as migration, apoptosis, proliferation and differentiation [8][9][10]. MiR-301a-3p expresses in many tissues, which belongs to miR-301 family.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN

Zhang

Liu

2020

Bioengineered

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Human esophageal carcinoma (EC) is a common cancer, which leads to many deaths worldwide every year. Our study aimed to explore the mechanism of miR-301a-3p regulating the proliferation of esophageal squamous cell carcinoma (ESCC) cells. We had collected ESCC tissues and adjacent normal esophageal tissues from 47 patients. The relative levels of miR-301a-3p/U6 in ESCC tissues and cells were analyzed by real-time PCR. And we measured the relative protein levels of PTEN, BCL-2, BAX, and p-AKT/AKT by Western blot. Eca-109 cell proliferation was detected by MTT assay and colony formation. Compared with adjacent normal esophageal tissues, the relative level of miR-301a-3p/U6 was elevated in ESCC tissues. MiR-301a-3p could facilitate ESCC cell proliferation. And miR-301a-3p directly bind to PTEN 3ʹ-UTR and negatively regulated PTEN protein expression. Moreover, silencing PTEN could reversed inhibited proliferation of Eca-109 cells induced by miR-301a-3p inhibitor, while overexpression PTEN could reversed enhanced proliferation of Eca-109 cells induced by miR-301a-3p mimic. Taken together, miR-301a-3p promoted ESCC cell proliferation by supressing PTEN.

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The role of microRNAs in prostate cancer migration, invasion, and metastasis

Cited by 46 publications

References 163 publications

MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer

MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer

Progression or suppression: Two sides of the innate lymphoid cells in cancer

MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN

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