The role of microRNAs involved in PI3‐kinase signaling pathway in colorectal cancer

Noorolyai, Saeed; Mokhtarzadeh, Ahad; Baghbani, Elham; Asadi, Milad; Baghbanzadeh, Amir; Mogaddam, Mahsa Maleki; Baradaran, Behzad

doi:10.1002/jcp.27415

Cited by 28 publications

(13 citation statements)

References 111 publications

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“…miRNAs are short non-coding RNAs that bind mRNAs, causing translation inhibition or transcript degradation, which ultimately results in a loss of PTEN expression and activation of the PI3K/Akt signaling cascade. Several miRNAs [61,62] and a complex of RBP known as Musashi-1/2 [63], targeting PTEN in CRC, have been identified. Therefore, modulation of those regulatory RNAs and RNA-binding proteins represent a therapeutic strategy aiming at restoring PTEN translation and expression, exploiting its antitumor activity and increasing cellular drug sensitivity.…”

Section: Pten As a Targetmentioning

confidence: 99%

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target

Salvatore

Calegari

Loupakis

et al. 2019

Cancers

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Molecular assessment of colorectal cancer (CRC) is receiving growing attention, beyond RAS and BRAF, because of its influence on prognosis and prediction in cancer treatment. PTEN (phosphatase and tensin homologue), a tumor suppressor, regulating cell division and apoptosis, has been explored, and significant evidence suggests a role in cetuximab and panitumumab resistance linked to the epidermal growth factor receptor (EGFR) signal transduction pathway. Factors influencing PTEN activity should be analyzed to develop strategies to maximize the tumor suppressor role and to improve tumor response to cancer treatment. Therefore, an in-depth knowledge of the PI3K-Akt pathway—one of the major cancer survival pathways—and the role of PTEN—a major brake of this pathway—is essential in the era of precision medicine. The purpose of this literature review is to summarize the role of PTEN as a predictive factor and possible therapeutic target in CRC, focusing on ongoing studies and the possible implications in clinical practice.

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Section: Pten As a Targetmentioning

confidence: 99%

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target

Salvatore

Calegari

Loupakis

et al. 2019

Cancers

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“…PTEN is a dominant cancer-suppressor gene blocking PI3K-Akt pathway via PIP3. Emerging evidence revealed PTEN deficiency, mutation or inexpression has been discovered in a lot of malignant tumors, such as the liver, breast, lung, brain, and prostate cancers [25,[39][40][41][42][43][44]. Our findings showed that the exosome-laden miR-155 directly targeted PTEN and lead to the decrease of respective target protein in recipient cells, and then activated the PI3K-Akt pathway.…”

Section: Discussionmentioning

confidence: 58%

Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN

Sun

Zhang²,

Gao

et al. 2019

Med Sci Monit Basic Res

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BackgroundMost eukaryocytes release nano vesicles (30–120 nm), named exosomes, to various biological fluids such as blood, lymph, and milk. Hepatocellular carcinoma (HCC) is one of the tumors with the highest incidence rate in primary malignant carcinoma of the liver. However, the mechanism of HCC proliferation remains elusive. In this study, we aim to explore whether HCC cell-derived exosomes affect the proliferation of cancer cells.Material/MethodsExosomes were isolated from HCC cells by ultracentrifugation and were visualized the phenotype by transmission electron microscopy. Cell proliferation was detected by Cell Counting Kit-8 assays and EdU (5-ethynyl-2-deoxyuridine) incorporation assays. Dual-luciferase assays were performed to validate the paired correlation of miR-155 and 3′-UTR of PTEN (gene of phosphate and tension homology deleted on chromosome 10). A xenograft mice model was constructed to verify the effect of exosome-mediated miR-155 on cell proliferation in vivo.ResultsOur finding showed that miR-155 was enriched in exosomes released from HCC cells. The exosome-containing miR-155 transferred into new HCC targeted cells and lead to the elevation of HCC cells’ proliferation. Besides, the exosomal miR-155 directly bound to 3′-UTR of PTEN leading to the reduction of relevant targets in recipient liver cells. The knockdown of PTEN attenuated the proliferation of HCC cells treated with the exosomal miR-155. Moreover, nude-mouse experiment results revealed a promotional effect of the exosomal miR-155 on HCC cell-acquired xenografts.ConclusionsOur study indicated that exosomal-specific miR-155 transfers to adjacent and/or more distant cells and stimulates the proliferation of HCC cells.

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“…Cancer has always been one of the most important issues affecting human life span and quality of life, which is considered as a bioheterogeneous disease caused by distinct abnormal changes in genetic material (Kumar & Sharawat, 2018; Noorolyai et al, 2019; Uscanga‐Palomeque et al, 2019). The American Association for Cancer Research (AACR) Cancer Progress Report 2019 indicated that 17 million people were diagnosed with cancer and 9.5 million died of cancer globally in 2018 (Sengupta & Honey, 2019).…”

Section: Introductionmentioning

confidence: 99%

Emerging role of RNF2 in cancer: From bench to bedside

Yan

Chen

et al. 2021

Journal Cellular Physiology

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RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub). RNF2 gene is located at the 1q25.3 site of human chromosome and the coding region is composed of 9 exons, encoding 336 amino acids in total. Many studies have demonstrated that overexpressed RNF2 was involved in the pathological progression of multiple cancers and has an impact on their clinical features. For instance, the upregulated expression level of RNF2 is positively correlated with the occurrence and progression of hepatocellular carcinoma, melanoma, prostate cancer, breast cancer, pancreatic cancer, gastric cancer, and bladder urothelial carcinoma, as well as with the radioresistance of lung cancer and chemoresistance of ovarian cancer. This review provides an up‐to‐date perspective on the relationship between RNF2 and several cancers and highlights recent studies on RNF2 regulation. In particular, the relevant cellular signaling pathways and potential clinical value of RNF2 in cancers are also discussed, suggesting its potential as an epigenetic biomarker and therapeutic target for these cancers.

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The role of microRNAs involved in PI3‐kinase signaling pathway in colorectal cancer

Cited by 28 publications

References 111 publications

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target

Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN

Emerging role of RNF2 in cancer: From bench to bedside

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