The role of microvesicles in tissue repair

Tetta, Ciro; Bruno, Stefania; Fonsato, Valentina; Deregibus, Maria Chiara; Camussi, Giovanni

doi:10.4161/org.7.2.15782

Cited by 109 publications

(75 citation statements)

References 81 publications

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“…The growing body of functional studies on the pathophysiological roles of EVs have provided evidence of major roles in immune regulation (19,20), and cell-cell communication via the transfer of bioactive molecules including proteins (21,22), lipids (23,24), and nucleic acids (25,26). The influence exerted by EVs on a multitude of physiological processes (27,28) and pathological disorders (29 -31) have rendered these structures as highly promising targets for clinical biomarker discovery. Moreover, the ability of EVs to deliver protein cargo and elicit a functional response from distant cell types and tissues also indicates considerable potential for exploitation as vehicles for drug delivery.…”

mentioning

confidence: 99%

Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury

Cheow

Cheng

Lee

et al. 2016

Molecular & Cellular Proteomics

107

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Myocardial infarction (MI) triggers a potent inflammatory. We further present that EV-derived fibrinogen components were paradoxically down-regulated in MI, suggesting that a compensatory mechanism may suppress post-infarct coagulation pathways, indicating potential for therapeutic targeting of this mechanism in MI. Taken together, these data demonstrated that plasma EVs contain novel diagnostic biomarkers and therapeutic targets that can be further developed for clinical use to benefit patients with coro-

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mentioning

confidence: 99%

Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury

Cheow

Cheng

Lee

et al. 2016

Molecular & Cellular Proteomics

107

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“…interleukin-6, tumor factor necrosis-alpha, leptin, and vistafin, may directly influence structure of endothelial cells and trigger a secretion of apoptotic EMPs (Berezin, 2016b;Rautou et al, 2011 process is attenuation of endothelial cell repair and recovery of vascular function (Jansen et al, 2015). Unfortunately, co-existing IR affects endothelial progenitor cells and they are not able to differentiate into functionally mature endothelial cells even after stimulation by apoptotic EMPs (Martinez and Andriantsitohaina, 2011;Tetta et al, 2011). As a result, apoptotic EMP-induced endothelial dysfunction and IR may become an early predictor of shaping Met-UHO.…”

Section: Discussionmentioning

confidence: 99%

Circulating apoptotic endothelial cell-derived microparticles are predicted metabolically unhealthy obesity

Berezin

Kremzer

Berezina³

et al. 2017

Biomed Res Ther

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Introduction: Circulating apoptotic endothelial cell-derived micro particles (EMPs) are a marker of endothelial dysfunction and cardiovascular (CV) risk in type 2 diabetes mellitus patients. There is evidence regarding association between apoptotic EMP number and CV disease in obese individuals. The aim of the study to investigate whether increased number of circulating apoptotic EMPs may predict transformation of Met-HO into Met-UHO. Methods: The study was retrospectively evolved 89 patients with established abdominal obesity (47 patients with Met-UHO determined as MetS and 42 subjects with Met-HO) from the large cohort of abdominal obesity patients (n=268). Thirty five healthy volunteers matched for age and sex were involved in the study as a control cohort. Obesity-related biomarker (adiponectin, leptin, vistafin) and EMPs were measured at baseline. Flow cytometry was used to determine EMPs with immune phenotype CD31+/ annexin V+ and CD144+/annexin V+. Results: There was not found a significant difference between numbers of EMPs labeled CD31 + / Annexin V + in Met-UHO and Met-HO patients, while Met-UHO patients had a significantly increased level of circulating CD144 + / Annexin V + compared with Met-HO individuals. Multivariate logistic regression analysis has revealed the HOMA-IR, number of CV risk factors, serum leptin and hs-CRP independently predicted numbers of circulating CD31 + / Annexin V + and CD144 + / Annexin V + EMPs in Met-UHO. In Met-HO patients HOMA-IR remained an independent predictor of increased numbers of circulating CD31 + / Annexin V + and CD144 + / Annexin V + EMPs. Conclusion: in the investigation we found that the increased number of CD31 + /Annexin V + and CD144 + / Annexin V + EMPs added to the based predictive model (HOMA-IR) may predict transformation of Met-HO into Met-UHO.

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“…It has been shown that infusion of MSCs after kidney transplantation is feasible and restricts T memory cell expansion while enlarging the T regulatory population, even if graft dysfunction is induced. One possible alternative to the MSC infusion in organ transplantation might be MV treatment [61].…”

Section: Microparticles In Kidney Transplantationmentioning

confidence: 99%