The Role of Military Dental Capabilities in Mass Fatality Situations

Trengrove, Hugh G.; Gray, Andrew

doi:10.7205/milmed-d-12-00399

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…This suggests an additional mechanism by which SOCS6 regulates insulin signaling downstream of the receptor to control glucose metabolism. Similar to the engagement of LRIG1 with many RTKs, in vitro studies suggest that SOCS proteins regulate multiple RTKs including c-KIT, FLT3, IR, IGF-1R, and EGFR by enhancing their degradation via recruitment of E3 ubiquitin ligase complexes (Banks et al, 2005;Kario et al, 2005;Krebs et al, 2002;Nicholson et al, 2005;Trengrove and Gray, 2013). A subset of SOCS proteins -SOCS2, SOCS6, and SOCS7protect RTKs from SOCS-mediated degradation by interacting with the domains of other SOCS proteins responsible for the recruitment of E3 ubiquitin ligase complexes (Piessevaux et al, 2006).…”

Section: Late Attenuation Of Rtk Signaling Via Receptor Ubiquitination and Degradationmentioning

confidence: 97%

“…Although the biological roles of SOCS proteins have traditionally been considered in the context of cytokine receptor signaling through the JAK/STAT pathway in immunity and hematopoiesis, emerging evidence implicates SOCS proteins in the control of RTK signaling during development (Supplemental Table 1) (Trengrove and Gray, 2013). In vitro and in vivo studies demonstrated that SOCS2 exerts a dual role in the regulation of EGF signaling: Socs2 knockout mice displayed increased intestinal growth due to enhanced responsiveness to EGF (Michaylira et al, 2006), and cortical neurons derived from transgenic Socs2 overexpressing mice had increased neural outgrowth, apparently also due to enhanced EGF signaling (Goldshmit et al, 2004).…”

Section: Late Attenuation Of Rtk Signaling Via Receptor Ubiquitination and Degradationmentioning

confidence: 99%

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Feedback regulation of RTK signaling in development

Neben

Jura

et al. 2019

Developmental Biology

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Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling is critical for the execution of cellular programs and behaviors. Understanding these control mechanisms has important implications for the field of developmental biology, and in recent years, the question of how augmentation or attenuation of RTK signaling via feedback loops modulates development has become of increasing interest. RTK feedback regulation is also important for human disease research; for example, germline mutations in genes that encode RTK signaling pathway components cause numerous human congenital syndromes, and somatic alterations contribute to the pathogenesis of diseases such as cancers. In this review, we survey regulators of RTK signaling that tune receptor activity and intracellular transduction cascades, with a focus on the roles of these genes in the developing embryo. We detail the diverse inhibitory mechanisms utilized by negative feedback regulators that, when lost or perturbed, lead to aberrant increases in RTK signaling. We also discuss recent biochemical and genetic insights into positive regulators of RTK signaling and how these proteins function in tandem with negative regulators to guide embryonic development.

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Section: Late Attenuation Of Rtk Signaling Via Receptor Ubiquitination and Degradationmentioning

confidence: 97%

Section: Late Attenuation Of Rtk Signaling Via Receptor Ubiquitination and Degradationmentioning

confidence: 99%

Feedback regulation of RTK signaling in development

Neben

Jura

et al. 2019

Developmental Biology

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“…Os trabalhos nestes locais requerem pessoas com formação individual e coletiva com vista a atenuar as ameaças ocupacionais e ambientais. O treinamento e preparação desta natureza é uma exigência básica militar e facilmente se traduz em operações de identificação em desastres de massa [15].…”

Section: Demystifying the Mysteries: Sexual Dimorphism In Primaryunclassified

Odontologia Forense: sua importância e meios de identificação post mortem

Trevisol¹,

Tiecher

Coelho

et al. 2021

Rev. Bras. Crimin.

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A Odontologia Forense é uma especialidade que investiga os processos físicos, químicos e biológicos que podem ter provocado danos a um indivíduo, auxiliando a justiça na identificação de indivíduos mortos. O presente estudo objetiva comprovar, através de evidências científicas existentes na literatura, a importância da Odontologia Forense. Trata-se de uma revisão de literatura sistematizada qualitativa, a qual realizou-se levantamento bibliográfico a partir de seleção de literatura tradicional e artigos em bases de dados online, utilizando os seguintes descritores: “Forensic Anthropology”; “Forensic sciences”; “Human identification”, “Microsatellite Repeats” e suas combinações. Foram incluídos estudos sobre Odontologia Forense, publicados na língua portuguesa e inglesa, sem limitação de data de publicação. Foram encontrados 1853 artigos, dentre os quais 20 se enquadraram nos critérios de inclusão, sendo eles: relato de caso clínico, estudos transversais e revisão da literatura. A Odontologia Forense mostra sua importância em variados casos, na maioria deles a identificação é obtida através dos arcos dentários que permitem identificar grupo racial, sexo, altura, idade, e os dados ante mortem, em que observam-se dados dos tratamentos odontológicos ocorridos ante mortem e compara-se com post mortem. Verificou-se com os resultados obtidos que a Odontologia Forense possui grande importância em variados casos de investigação, devido ao fato de os elementos dentários resistirem por mais tempo a condições desfavoráveis, havendo assim a possibilidade de obtenção de material genético através destes elementos.

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Future-ready military healthcare: Forensic odontology training and digital dental records integration in the Indian Armed Forces

Prakash

2024

Medical Journal Armed Forces India

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The Role of Military Dental Capabilities in Mass Fatality Situations

Cited by 4 publications

References 27 publications

Feedback regulation of RTK signaling in development

Feedback regulation of RTK signaling in development

Odontologia Forense: sua importância e meios de identificação post mortem

Future-ready military healthcare: Forensic odontology training and digital dental records integration in the Indian Armed Forces

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