2018
DOI: 10.1038/s41420-018-0096-8
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The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism

Abstract: This study aims to investigate the role of miR-106b-5p in cervical cancer by performing a comprehensive analysis on its expression and identifying its putative molecular targets and pathways based on The Cancer Genome Atlas (TCGA) dataset, Gene Expression Omnibus (GEO) dataset, and literature review. Significant upregulation of miR-106b-5p in cervical cancer is confirmed by meta-analysis with the data from TCGA, GEO, and literature. Moreover, the expression of miR-106b-5p is significantly correlated with the n… Show more

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Cited by 18 publications
(16 citation statements)
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“…While, such recent studies link Cathepsin transcriptional expression to an alternative mode of regulation through the miRNAs, more importantly, such studies also highlight the relative importance of miRNA as a potential therapeutic in overcoming Cathepsin-mediated chemoresistance and Cathepsin-mediated EMT regulation [77]. As seen previously, mir152 has been linked to regulating Wnt-mediated EMT inhibition [78] and mir106b-5p with the regulation of key signaling intermediates such as GSK3B, VEGFA and PTK2 in colon and cervical cancers [79] and in both of which, Cathepsins A and L are seen to play a vital regulatory role. Thus, it is conceivable that these miRNAs could be regulating these Cathepsins and other key signaling pathway intermediates simultaneously, or exclusively in a time-dependent and coordinated manner.…”
Section: Signalling Network and Cathepsin Expressionmentioning
confidence: 83%
“…While, such recent studies link Cathepsin transcriptional expression to an alternative mode of regulation through the miRNAs, more importantly, such studies also highlight the relative importance of miRNA as a potential therapeutic in overcoming Cathepsin-mediated chemoresistance and Cathepsin-mediated EMT regulation [77]. As seen previously, mir152 has been linked to regulating Wnt-mediated EMT inhibition [78] and mir106b-5p with the regulation of key signaling intermediates such as GSK3B, VEGFA and PTK2 in colon and cervical cancers [79] and in both of which, Cathepsins A and L are seen to play a vital regulatory role. Thus, it is conceivable that these miRNAs could be regulating these Cathepsins and other key signaling pathway intermediates simultaneously, or exclusively in a time-dependent and coordinated manner.…”
Section: Signalling Network and Cathepsin Expressionmentioning
confidence: 83%
“…Meanwhile, miR-106b could promote cervical cancer progression by modulating the expression of the GSK3B, VEGFA, and PTK2 genes. Importantly, these three genes play crucial roles in PI3K-Akt signaling, focal adhesion and cancer [43]. Further, the expression of miR-106b was inversely correlated with TGF-β type II receptor protein level; and miR-106b can directly inhibit the TGF-β type II receptor translation in vitro [44], while TGF-β receptor binding is an important molecular function in diabetic neuropathic pain from our previous study [27].…”
Section: Discussionmentioning
confidence: 78%
“…86 This platform has aided in study-specific correlation analysis between TF/miRNA and their target genes that has helped in deriving useful insights into hepatocellular carcinoma 93 and cervical cancers. 94…”
Section: Portals For Visualization and Interpretation Of Multi-omics mentioning
confidence: 99%