The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy

Abstract

A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.

Dissecting the Methylomes of EGFR-Amplified Glioblastoma Reveals Altered DNA Replication and Packaging, and Chromatin and Gene Silencing Pathways

“…According to Budi et al, miR128 is involved in cancer development, progression and therapy response [ 22 ]. Thereby, miR128 is associated with many different cellular processes, such as cell proliferation and self-renewal, chemotherapeutic resistance, cell growth and differentiation, angiogenesis and senescence, and apoptosis [ 22 ].…”

“…According to Budi et al, miR128 is involved in cancer development, progression and therapy response [ 22 ]. Thereby, miR128 is associated with many different cellular processes, such as cell proliferation and self-renewal, chemotherapeutic resistance, cell growth and differentiation, angiogenesis and senescence, and apoptosis [ 22 ]. Decreased expression of miR128 has been described in a broad range of cancers, such as breast cancer, lung cancer, thyroid cancer, laryngeal cancer, head and neck cancer, melanoma, osteosarcoma, leukemia, and glioma [ 22 ].…”

miRNAs in the Box: Potential Diagnostic Role for Extracellular Vesicle-Packaged miRNA-27a and miRNA-128 in Breast Cancer

“…This miRNA has been identified in the thymus, skeletal muscle, and brain, with high concentrations during neural development [52]. In addition to its physiological involvement in normal cellular processes, miRNA-128 plays an important regulatory role in a variety of cancers, including glioblastoma, leukemia, thyroid, lung and breast cancers [53]. The expression of miRNA-128 was found to be reduced in the majority of cancer tissues compared to that in healthy control tissues and correlated with shorter survival [54][55][56][57][58][59][60], although increased miRNA-128 levels have also been evidenced in a few reports [61,62].…”

Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases

“…MiRNA-128 is embedded on CHR 2q21.3 and 3p22.3 ( 59 ). MiRNA-128 is often considered as a potential therapeutic target to regulate vascular smooth muscle cells ( 60 ).…”