The role of miR‐146a in viral infection

Nahand, Javid Sadri; Karimzadeh, Mohammad Reza; Nezamnia, Maria; Fatemipour, Maryam; Khatami, Alireza; Jamshidi, Sogol; Moghoofei, Mohsen; Taghizadieh, Mohammad; Hajighadimi, Sarah; Shafiee, Alimohammad; Sadeghian, Mohammad Hadi; Bokharaei‐Salim, Farah; Mirzaei, Hamed

doi:10.1002/iub.2222

Cited by 61 publications

(37 citation statements)

References 146 publications

(325 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, overexpression of hsa-miR-146a leads to decreased phosphorylation of NF-кB during infection [ 24 ]. The conclusions were similar to another finding which demonstrated that increased expression of hsa-miR-146a enhanced DENV replication by targeting the TRAF6-mediated NF-кB pathway [ 49 ]. These results suggested a role of hsa-miR-146a-mediated targeting of the NF-кB pathway during CHIKV pathogenesis.…”

Section: Role Of Mirnas During Chikv Infectionsupporting

confidence: 90%

“…Many reports have suggested that joint inflammation is associated with arthritic-like symptoms during CHIKV infection [ 147 ]. hsa-miR-146 has been associated with many viral and microbial infections and also with inflammatory conditions such as RA [ 49 , 148 , 149 ]. An upregulated expression of hsa-miR-146a was observed in synovial fibroblasts during CHIKV infection [ 24 ].…”

Section: Possible Role Of Mirnas In Bone Homeostasis In the Contexmentioning

confidence: 99%

See 1 more Smart Citation

Role of MicroRNAs in Bone Pathology during Chikungunya Virus Infection

Roy

Byrareddy

Reid

2020

Viruses

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) is an alphavirus, transmitted by mosquitoes, which causes Chikungunya fever with symptoms of fever, rash, headache, and joint pain. In about 30%–40% of cases, the infection leads to polyarthritis and polyarthralgia. Presently, there are no treatment strategies or vaccine for Chikungunya fever. Moreover, the mechanism of CHIKV induced bone pathology is not fully understood. The modulation of host machinery is known to be essential in establishing viral pathogenesis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate major cellular functions by modulating gene expression. Fascinatingly, recent reports have indicated the role of miRNAs in regulating bone homeostasis and altered expression of miRNAs in bone-related pathological diseases. In this review, we summarize the altered expression of miRNAs during CHIKV pathogenesis and the possible role of miRNAs during bone homeostasis in the context of CHIKV infection. A holistic understanding of the different signaling pathways targeted by miRNAs during bone remodeling and during CHIKV-induced bone pathology may lead to identification of useful biomarkers or therapeutics.

show abstract

Section: Role Of Mirnas During Chikv Infectionsupporting

confidence: 90%

Section: Possible Role Of Mirnas In Bone Homeostasis In the Contexmentioning

confidence: 99%

Role of MicroRNAs in Bone Pathology during Chikungunya Virus Infection

Roy

Byrareddy

Reid

2020

Viruses

View full text Add to dashboard Cite

show abstract

“…These molecules exert their effects via targeting a variety of molecular and cellular mechanisms [148][149][150][151][152]. Hence, miRNAs could be used as diagnostic, prognostic and therapeutic biomarkers in the treatment of different diseases such as stroke, cancer, cardiovascular diseases, infection diseases, diabetes, and viral infections [153][154][155][156][157][158][159][160][161][162][163].…”

Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

View full text Add to dashboard Cite

Cancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.

show abstract

“…Considering the increased level of STAT1 and other targets of miR-146a in the lungs of patients infected with SARS-CoV-2, miR-146a can be decreased in SARS-CoV-2 infection. The preventive role of STAT1 against SARS-CoV replication has been previously reported [ 43 ]. In order to retaliate, SARS-CoV encodes a STAT1 antagonist (ORF6) to escape from eradication [ 44 ].…”

Section: Discussionmentioning

confidence: 97%

“…MiR-146a is predicted to target 21 up-regulated genes in SARS-CoV-2 infection. The increased level of miR-146a in a wide range of viral infections including HCV, HBV, influenza A, HIV, H1N1, H3N2, and EBV has been previously reported [ 43 ]. miR-146a protects the virus against the host through targeting and inhibiting STAT1 protein.…”

Section: Discussionmentioning

confidence: 98%