The Role of miR-23b in Cancer and Autoimmune Disease

Guo, Yuxin; Wang, Na; Wu, Wei; Li, Cuiqin; Chen, Ruiheng; Zhang, Yuan; Li, Xing

doi:10.1155/2021/6473038

Cited by 20 publications

(11 citation statements)

References 105 publications

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“…MiR-23b plays contrary roles in different types of cancer but is a tumor suppressor miRNA in EC 29 , 30 . MiR-23b targets metastasis-associated in colon cancer-1 (MACC1) inhibiting EC cells proliferation, invasion, and migration.…”

Section: Discussionmentioning

confidence: 99%

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

Klicka

Grzywa

Klinke

et al. 2022

Sci Rep

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Endometrial cancer (EC) is one of the most common types of cancer of the female reproductive system. EC is classified into two types (EC1 and EC2). MiRNAs are single-stranded RNA molecules that regulate gene expression posttranscriptionally. They have aberrant expression profiles in cancer, including EC. This study aimed to assess the level of expression of a panel of 16 miRNAs in both types of EC and healthy endometrium (HE). A total of 45 patients were enrolled into the study, 18 patients diagnosed with EC1, 12 diagnosed with EC2, and 15 HE controls. Tumor tissues or healthy endometrial tissues were dissected from archival formalin-fixed paraffin-embedded (FFPE) using laser capture microdissection (LCM). RNA was isolated from collected material and the expression of selected miRNAs was determined using the real-time qPCR. We found that miR-23b, miR-125b-5p, miR-199a-3p, miR-221-3p, and miR-451a were downregulated in EC in comparison to HE. Moreover, the expression of miR-34a-5p and miR-146-5p was higher in EC1 compared to EC2. Analysis of The Cancer Genome Atlas (TCGA) database confirmed decreased levels of miR-23b, miR-125b-5p, and miR-199a-3p in EC. Decreased miR-23b expression was associated with worse survival of EC patients.

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Section: Discussionmentioning

confidence: 99%

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

Klicka

Grzywa

Klinke

et al. 2022

Sci Rep

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“…miR-23b is a member of the miR-23-27-24 family which consists of two paralogs with the miR-23a cluster (miR-23a-27a-24-2) found on chromosome 19 and the intragenic miR-23b cluster (miR-23b27b-24-1) located on chromosome 9 within the C9orf3 gene [ 24 ]. Previous research suggested that miR-23b plays vital roles in cancer development where it exerts either oncogenic or tumor suppressor activity [ 25 , 26 ]. It is also implicated in the regulation of angiogenesis and endothelial cells homeostasis and may serve as biomarkers for the early diagnosis of acute myocardial infarction [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

First Trimester Maternal Plasma Aberrant miRNA Expression Associated with Spontaneous Preterm Birth

Mavreli

Theodora

Avgeris

et al. 2022

IJMS

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Spontaneous Preterm Delivery (sPTD) is one of the leading causes of perinatal mortality and morbidity worldwide. The present case–control study aims to detect miRNAs differentially expressed in the first trimester maternal plasma with the view to identify predictive biomarkers for sPTD, between 320/7 and 366/7 weeks, that will allow for timely interventions for this serious pregnancy complication. Small RNA sequencing (small RNA-seq) of five samples from women with a subsequent sPTD and their matched controls revealed significant down-regulation of miR-23b-5p and miR-125a-3p in sPTD cases compared to controls, whereas miR-4732-5p was significantly overexpressed. Results were confirmed by qRT-PCR in an independent cohort of 29 sPTD cases and 29 controls. Statistical analysis demonstrated that miR-125a is a promising early predictor for sPTL (AUC: 0.895; 95% CI: 0.814-0.972; p < 0.001), independent of the confounding factors tested, providing a useful basis for the development of a novel non-invasive predictive test to assist clinicians in estimating patient-specific risk.

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“…The results are well in line with previous clinical/preclinical studies suggesting mitochondrial dysfunction and decreased energy production in uterine endometriosis tissue, 48 as proline catabolism in mitochondria serves as an important source of energy production and previous transcriptomics studies have demonstrated that there is reduced expression of proline oxidase (POX, a mitochondrial inner-membrane flavoenzyme involved in the catabolic degradation of the proline) due to overexpression of microRNA (known as MiR-23b). 31 , 49 Epigenetics studies on clinical samples have demonstrated that miRNA-23b exhibits regulatory roles, especially in the development of cancer, 50 , 51 and its overexpression is negatively correlated with the expression of tumor suppressor gene TUSC7 in endometrial carcinoma. 52 Studies have shown that miRNA-23b directly binds the POX mRNA 3′-untranslated region; thus, the overexpression of miRNA-23b is directly correlated with downregulation of mitochondrial proline oxidase (POX), as schematically depicted in ( Figure 5 A).…”

Section: Discussionmentioning

confidence: 99%

Elevated Circulatory Proline to Glutamine Ratio (PQR) in Endometriosis and Its Potential as a Diagnostic Biomarker

et al. 2022

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Endometriosis (EM) is a hormone-dependent gynecological disease associated with chronic pelvic pain and altered immuno-inflammatory processes. It shares some cancer-like characteristics such as increased proline biosynthesis and activated glutaminolysis. Both proline and glutamine are interconvertible metabolically, and studies have shown their roles in cancer cell metabolic reprogramming, redox homeostasis, occurrence/development of endometrial carcinoma, and its further progression toward the malignant state. So based on this, we hypothesized that the circulatory proline to glutamine ratio (PQR) would be altered in EM and may serve as an indicative biomarker to improve the clinical diagnosis of EM. In present study, the circulatory-PQR levels were estimated for 39 EM patients and 48 age matched healthy female subjects using 800 MHz NMR spectroscopy. Among 39 EM patients, 15 were in the clinical stages I to II and referred to here as moderate EM (MEM) patients and 24 were in the clinical stages III to IV and referred here as severe EM (SEM) patients. The circulatory-PQR levels were significantly increased in EM patients (0.99 ± 0.13 μM in MEM; 1.39 ± 0.22 μM in SEM) compared to normal control (NC) subjects (0.52 ± 0.05 μM in NC). Further, the circulatory PQR levels exhibit the highest diagnostic potential with area under receiver operating characteristic (AUROC) curve values equal to 0.87 ± 0.04 [95%CI = 0.79–0.96] for MEM and 0.89 ± 0.04 [95% CI = 0.82–0.96] for SEM. These results suggested that circulatory-PQR has significant potential to serve as a noninvasive biomarker for diagnostic/prognostic screening of EM and further underscored the importance of these two nonessential amino acids (proline and glutamine) in cancer metabolism.

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The Role of miR-23b in Cancer and Autoimmune Disease

Cited by 20 publications

References 105 publications

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

Decreased expression of miR-23b is associated with poor survival of endometrial cancer patients

First Trimester Maternal Plasma Aberrant miRNA Expression Associated with Spontaneous Preterm Birth

Elevated Circulatory Proline to Glutamine Ratio (PQR) in Endometriosis and Its Potential as a Diagnostic Biomarker

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