2018
DOI: 10.1155/2018/3452748
|View full text |Cite
|
Sign up to set email alerts
|

The Role of miRNA-132 against Apoptosis and Oxidative Stress in Heart Failure

Abstract: Objective To explore the effect of microRNA-132 of heart failure and provide theoretical guidance for clinical treatment of heart failure (HF). Methods Peripheral blood was collected from HF patients. RT-qPCR was used to determine microRNA-132 expression. Mouse models of heart failure were established. Color Doppler ultrasound was utilized to measure the changes of cardiac function. HE and Masson staining were applied to observe pathological changes of the myocardium. After H9C2 cells were transfected with mic… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
33
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 33 publications
(33 citation statements)
references
References 23 publications
0
33
0
Order By: Relevance
“…Previous studies have shown that miRNA-132-3p is involved in complicated and comprehensive regulatory networks, including neurological development [31], heart failure [32,33], inflammation [34], angiogenesis [35], and even cancer [36]. However, the roles it plays in osteogenic differentiation, particularly during mechanical unloading conditions, are first reported by our group.…”
Section: Discussionmentioning
confidence: 88%
“…Previous studies have shown that miRNA-132-3p is involved in complicated and comprehensive regulatory networks, including neurological development [31], heart failure [32,33], inflammation [34], angiogenesis [35], and even cancer [36]. However, the roles it plays in osteogenic differentiation, particularly during mechanical unloading conditions, are first reported by our group.…”
Section: Discussionmentioning
confidence: 88%
“…We found a targeted relationship between miR-195-5p and Smad3 through online website prediction, and Smad3 is one of the key factors in this pathway. Previous studies [25] have reported that miR-132 can induce cardiomyocyte apoptosis in HF by regulating Smad3. In our research, we also found that this signaling pathway was dramatically activated in HF rats.…”
Section: Discussionmentioning
confidence: 93%
“…The expression of miR-132 was increased in isoproterenol-induced cardiac hypertrophy [ 26 ]. MiR-132 expression was down-regulated in the blood of heart failure patients [ 21 ]. However, another study showed that circulating miR-132 levels rose with the severity of heart failure in patients with chronic heart failure [ 20 ].…”
Section: Discussionmentioning
confidence: 99%
“…Circulating miR-132 level was associated with heart failure, and it rose with the severity of heart failure [ 20 ]. However, another study found that miR-132 expression was down-regulated in the blood of heart failure patients [ 21 ]. Moreover, overexpression of miR-132 dramatically enhanced the antioxidant stress and antiapoptotic ability of H9C2 cells [ 21 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation