The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance

Gajda, Ewa; Grzanka, Małgorzata; Godlewska, Marlena; Gawel, Damian

doi:10.3390/ph14020149

Cited by 15 publications

(11 citation statements)

References 165 publications

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“…MiR-7-5p connects different signaling pathways through feedback and feedforward loops and is involved in differentiation, regulation of proliferation, apoptosis, migration, chromatin remodeling, and multidrug resistance. [ 53 , 54 ] MiR-7 acts mainly as a tumor suppressor in various cancer types [ 53 ] ; however, evidence suggests that it may also act as an oncogene in lung cancer. [ 55 ] Elevated miR-7 expression levels in lung tumors compared to normal tissues and metastases have been found in previous studies.…”

Section: Discussionmentioning

confidence: 99%

MiRNA expression profiling in adenocarcinoma and squamous cell lung carcinoma reveals both common and specific deregulated microRNAs

et al. 2022

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The current study investigated the expression signatures of miRNAs in lung adenocarcinoma (LUAD) and squamous cell lung carcinoma (LUSC). miRNA profiling was performed using microarray in 12 LUAD and 12 LUSC samples and adjacent normal tissues. In LUAD, 107 miRNAs were significantly deregulated, whereas 235 miRNAs were deregulated in LUSC. Twenty-six miRNAs were common between the 2 cancer subtypes and 8 were prioritized for validation, in addition to 6 subtype-specific miRNAs. The RT-qPCR validation samples included 50 LUAD, 50 LUSC, and adjacent normal tissues. Eight miRNAs were validated in LUAD: 3 upregulated -miR-7-5p, miR- 375-5p, miR-6785-3p, and 5 downregulated -miR-101-3p, miR-139-5p, miR-140-3p, miR-144-3p, miR-195-5p. Ten miRNAs were validated in the LUSC group: 3 upregulated -miR-7-5p, miR-21-3p, miR-650, and 7 downregulated -miR- 95-5p, miR-140-3p, miR-144-3p, miR-195-5p, miR-375, miR-744-3p, and miR-4689-3p. Reactome pathway analysis revealed that the target genes of the deregulated miRNAs in LUAD were significantly enriched in cell cycle, membrane trafficking, gene expression processes, and EGFR signaling, while in LUSC, they were enriched in the immune system, transcriptional regulation by TP53, and FGFR signaling. This study identified distinct miRNA profiles in LUSC and LUAD, which are common and specific miRNAs that could be further investigated as biomarkers for diagnosis and prognosis.

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Section: Discussionmentioning

confidence: 99%

MiRNA expression profiling in adenocarcinoma and squamous cell lung carcinoma reveals both common and specific deregulated microRNAs

et al. 2022

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“…Hence, it is crucial to further explore whether TRMT112 promotes tumorigenesis and development by interacting with SART1. As oncogenes or tumor suppressor genes [ 42 , 43 ], noncoding RNAs, such as lncRNA, miRNA, and tRNA, participate in the regulation of cell proliferation [ 44 , 45 ], apoptosis [ 46 ], metastasis [ 47 , 48 ], differentiation [ 49 ], and other biological processes. GO enrichment and KEGG analyses illustrated that TRMT112 might be implicated in tumorigenesis and development through modulating RNA metabolism and transport pathways.…”

Section: Discussionmentioning

confidence: 99%

Pan-Cancer Analysis Reveals the Relation between TRMT112 and Tumor Microenvironment

Jiang

Yao

et al. 2022

Journal of Oncology

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Dysregulated epigenetic modifications play a critical role in cancer development where TRMT112 is a member of the transfer RNA (tRNA) methyltransferase family. Till now, no studies have revealed the linkage between TRMT112 expression and diverse types of tumors. Based on TCGA data, we first probed into the relation between TRMT112 and prognosis and the potential role of TRMT112 in tumor microenvironment across 33 types of tumor. TRMT112 presented with increased expression in most cancers, which was significantly prognostic. Furthermore, TRMT112 was associated with tumor-associated fibroblasts in a variety of cancers. Additionally, a positive relationship was identified between TRMT112 expression and multiple tumor-related immune infiltrations, such as dendritic cells, CD8+ T cells, macrophages, CD4+ T cells, neutrophils, and B cells in lung adenocarcinoma and breast invasive carcinoma. In summary, our results suggest that TRMT112 might be a potential prognostic predictor of cancers and involved in regulating multiple cancer-related immune responses to some extent.

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“…So far, many studies have demonstrated that miR-7 is a tumor suppressor, and the downregulation of miR-7 is usually closely related to the occurrence and development of tumors [ 19 , 20 , 21 ]. Based on the previous research progress, our team found that the -604 and -617 sites of the miR-7-2 promoter region in lung cancer tissues were mutated, and miR-7 expression with promoter site mutation was lower than that with non-mutated in tumor tissues.…”

Section: Microrna Genomic Variationmentioning

confidence: 99%

Mechanisms Controlling MicroRNA Expression in Tumor

Chen

Wang

et al. 2022

Cells

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MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tumorigenesis. MiRNA-based cancer gene therapy has consistently shown promising anti-tumor effects and is recognized as a new field in cancer treatment. So far, some clinical trials involving the treatment of malignancies have been carried out; however, studies of miRNA-based cancer gene therapy are still proceeding slowly. Therefore, furthering our understanding of the regulatory mechanisms of miRNA can bring substantial benefits to the development of miRNA-based gene therapy or other combination therapies and the clinical outcome of patients with cancer. Recent studies have revealed that the aberrant expression of miRNA in tumors is associated with promoter sequence mutation, epigenetic alteration, aberrant RNA modification, etc., showing the complexity of aberrant expression mechanisms of miRNA in tumors. In this paper, we systematically summarized the regulation mechanisms of miRNA expression in tumors, with the aim of providing assistance in the subsequent elucidation of the role of miRNA in tumorigenesis and the development of new strategies for tumor prevention and treatment.

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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance

Cited by 15 publications

References 165 publications

MiRNA expression profiling in adenocarcinoma and squamous cell lung carcinoma reveals both common and specific deregulated microRNAs

MiRNA expression profiling in adenocarcinoma and squamous cell lung carcinoma reveals both common and specific deregulated microRNAs

Pan-Cancer Analysis Reveals the Relation between TRMT112 and Tumor Microenvironment

Mechanisms Controlling MicroRNA Expression in Tumor

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