The role of miRNAs in the pathogenesis and therapeutic resistance of endometrial cancer: a spotlight on the convergence of signaling pathways

Abdelmaksoud, Nourhan M.; El-Mahdy, Hesham A.; Ismail, Ahmed; Elsakka, Elsayed G.E.; El-Husseiny, Ahmed A.; Khidr, Emad Gamil; Ali, Esraa; Rashed, Mohammed H.; El-Demerdash, Fatma El-Saeed; Doghish, Ahmed S.

doi:10.1016/j.prp.2023.154411

Cited by 52 publications

(1 citation statement)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiRNAs are capable of controlling the expression of various genes that play a role in the development of EC. Current studies indicate that miRNAs play a role in controlling tumor development and lymph node spread in living organisms, and in laboratory conditions, they participate in the invasion, movement, and epithelial-mesenchymal transition (EMT) of EC cells ( 106 ). Ran and colleagues demonstrated that suppressing HMGB1-driven autophagy through increased miR-218 expression can lessen EC cells’ resistance to paclitaxel, thereby reinstating their responsiveness to paclitaxel in resistant EC cells ( 104 ).…”

Section: The Significance Of Autophagy In Resistance To Drugs In Endo...mentioning

confidence: 99%

Advances in research on autophagy mechanisms in resistance to endometrial cancer treatment

Ji,

Cheng,

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Administering medication is a crucial strategy in improving the prognosis for advanced endometrial cancer. However, the rise of drug resistance often leads to the resurgence of cancer or less-than-ideal treatment outcomes. Prior studies have shown that autophagy plays a dual role in the development and progression of endometrial cancer, closely associated with drug resistance. As a result, concentrating on autophagy and its combination with medical treatments might be a novel approach to improve the prognosis for endometrial cancer. This study explores the impact of autophagy on drug resistance in endometrial cancer, investigates its core mechanisms, and scrutinizes relevant treatments aimed at autophagy, aiming to illuminate the issue of treatment resistance in advanced endometrial cancer.

show abstract

Section: The Significance Of Autophagy In Resistance To Drugs In Endo...mentioning

confidence: 99%