2024
DOI: 10.3390/ijms25116062
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The Role of Mitochondrial Copy Number in Neurodegenerative Diseases: Present Insights and Future Directions

Annamaria Cerantonio,
Luigi Citrigno,
Beatrice Maria Greco
et al.

Abstract: Neurodegenerative diseases are progressive disorders that affect the central nervous system (CNS) and represent the major cause of premature death in the elderly. One of the possible determinants of neurodegeneration is the change in mitochondrial function and content. Altered levels of mitochondrial DNA copy number (mtDNA-CN) in biological fluids have been reported during both the early stages and progression of the diseases. In patients affected by neurodegenerative diseases, changes in mtDNA-CN levels appea… Show more

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