The Role of Monocyte Chemoattractant Protein-1 in Experimental Chronic Pancreatitis Model Induced by Dibutyltin Dichloride in Rats

Inoue, Masanobu; Ino, Yoshifumi; Gibo, Junya; Ito, Tetsuhide; Hisano, Terumasa; Arita, Yoshiyuki; Nawata, Hajime

doi:10.1097/00006676-200211000-00023

Cited by 46 publications

(47 citation statements)

References 21 publications

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“…PDGF-B and PDGF-R␤, but not PDGF-R␣, are closely associated with fibrosis in human and experimental pancreatitis (Ebert et al, 1998;Haber et al, 1999). Furthermore, PDGF-B mRNA is up-regulated in dibutyltin dichloride-induced chronic pancreatitis (Inoue et al, 2002). We here found PDGF-R␤ mRNA to be up-regulated in the present model, whereas PDGF-B mRNA was unchanged.…”

Section: Tablesupporting

confidence: 52%

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats

Yamada

Kuno²,

Ogawa³

et al. 2004

J Pharmacol Exp Ther

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We recently demonstrated that both lisinopril and candesartan, an angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor blocker, respectively, attenuate pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori (WBN/Kob) rats. The purpose of the present study was to assess whether combination therapy with low doses of both, ineffective when given alone, might synergistically exert protective effects. Lisinopril, candesartan, or a combination of both in drinking water was administered to 10-week-old male WBN/Kob rats for 10 weeks. Parameters of inflammation and fibrosis, positive immunostaining for ␣-smooth muscle actin, and gene expression of cytokine and growth factors were assessed, as well as circulating renin-angiotensin system components. Dose-dependent effects of combination therapy were also investigated. Only combination therapy attenuated gross alterations in the pancreas, as quantitatively confirmed by increases in pancreatic weights and decreases in myeloperoxidase activity, hydroxyproline content, histologic scores, relative fibrosis area, and relative area of ␣-smooth muscle actin-positive cells. Combination therapy suppressed up-regulation of tumor necrosis factor-␣, platelet-derived growth factor-receptor ␤, and transforming growth factor-␤1 mRNA in the pancreas. Dose dependence of combination therapy was recognized with reference to improvement in these parameters. The conclusions are that combination therapy synergistically alleviated pancreatic inflammation and fibrosis in male WBN/Kob rats. This effect may be related to suppression of tumor necrosis factor-␣, plateletderived growth factor-receptor ␤, and transforming growth factor-␤1 mRNA. Compared with the either therapy alone, combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II type 1 receptor blocker may be more beneficial for treating chronic pancreatitis.

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Section: Tablesupporting

confidence: 52%

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats

Yamada

Kuno²,

Ogawa³

et al. 2004

J Pharmacol Exp Ther

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“…39 In addition, the PSC transformation indicated by the intrinsic fluorescence and the enlargement of PSCs before activation are observed in pancreatic tissues. However, the PSCs lose vitamin A autofluorescence after activation, which limits the simultaneous visualization of PSCs and the other pancreatic components.…”

Section: Discussionmentioning

confidence: 98%

Simultaneous characterization of pancreatic stellate cells and other pancreatic components within three-dimensional tissue environment during chronic pancreatitis

Hu¹,

2013

J. Biomed. Opt

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“…26 In brief, 6-week old SD rats were anesthetized by intraperitoneal injection of 50 mg/kg pentobarbital. Dibutyltin dichloride (DBTC; Schering AG, Berlin, Germany) was dissolved in ethanol (1 part) and then mixed with glycerol (2 parts) and dimethyl sulfoxide (2 parts).…”

Section: Induction Of Chronic Pancreatitis and Human Amsc Transplantamentioning

confidence: 99%

Effect of Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Rats With Acute and Chronic Pancreatitis

et al. 2016

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The Role of Monocyte Chemoattractant Protein-1 in Experimental Chronic Pancreatitis Model Induced by Dibutyltin Dichloride in Rats

Abstract: These results suggest that this experimental model of pancreatic fibrosis induced by DBTC in rats was useful as a chronic pancreatitis model and that MCP-1 may play an important role in the development of pancreatic fibrosis.

Cited by 46 publications

References 21 publications

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats

Simultaneous characterization of pancreatic stellate cells and other pancreatic components within three-dimensional tissue environment during chronic pancreatitis

Effect of Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Rats With Acute and Chronic Pancreatitis

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