The role of movement in embryonic joint development

Drachman, Daniel B.; Sokoloff, Leon

doi:10.1016/0012-1606(66)90022-4

Cited by 323 publications

(195 citation statements)

References 23 publications

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“…Previous studies of joint development in the chick have indicated that preventing muscle contraction can prevent articular cartilage and patella formation (Drachman and Sokoloff, 1966;Mikic et al, 2000). FE analysis of the interzone indicated that the articular cartilages and patella develop under the influence of very specific patterns of biophysical stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…Paralysis was reported to cause flattening and distortion of the articular surfaces (Drachman and Sokoloff, 1966), reduction in the volume of epiphyseal cartilage (Osborne et al, 2002), the loss of functional outgrowths (Murray and Drachman, 1969;Persson, 1983) and reduction or loss of joint-associated structures such as the patella and articular cartilage (Mikic et al, 2000;Osborne et al, 2002). Cell proliferation rates in the developing growth plate and chondroepiphysis were also downregulated by the removal of embryonic muscle contraction (Germiller and Goldstein, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint

Roddy

Kelly

et al. 2011

Journal of Biomechanics

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a b s t r a c tMuscle contractions begin in early embryonic life, generating forces that regulate the correct formation of the skeleton. In this paper we test the hypothesis that the biophysical stimulation generated by muscle forces may be a causative factor for the changes in shape of the knee joint as it grows. We do this by predicting the spatial and temporal patterns of biophysical stimuli, where cell proliferation and rudiment shape changes occur within the emerging tissues of the joint over time. We used optical projection tomography (OPT) to create anatomically accurate finite element models of the embryonic knee at three time points (stages) of development. OPT was also used to locate muscle attachment sites and AFM was used to determine material properties. An association was found between the emergence of joint shape, cell proliferation and the pattern of biophysical stimuli generated by embryonic muscle contractions. Elevated rates of growth and cell proliferation in the medial condyle were found to co-localise with elevated patterns of biophysical stimuli including maximum principal stresses and fluid flow, throughout the time period studied, indicating that cartilage growth and chondrocyte proliferation in the epiphysis is potentially related to local patterns of biophysical stimuli. The development of the patella and articular cartilages, which is known to be affected by in ovo immobilisation, could be contributed to by specific patterns of fluid flow, pore pressure and stress in the joint interzone. This suggests that both cartilage growth and tissue differentiation in the embryonic joint is regulated by specific patterns of biophysical stimuli and that these stimuli are needed for the correct development of the joint.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint

Roddy

Kelly

et al. 2011

Journal of Biomechanics

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“…However, thus far, studies into the role of embryo movement in development have focused on the musculoskeletal system. With this in mind, a number of studies have shown that limb-patterning events and early skeletal growth are insensitive to mechanical stimuli (Drachman and Sokoloff 1966;Hosseini and Hogg 1991;Pitsillides 2006). Although embryo movement starts as early as E4 in the chicken, joint cavitation and endochondral ossification are influenced by embryo movement only during the later phases of development, during which movement can be consistently monitored by the digital egg monitor, so it is certainly useful for the study of these phenomena.…”

Section: Discussionmentioning

confidence: 99%

Validating a Noninvasive Technique for Monitoring Embryo Movement In Ovo

Pollard

Pitsillides

Portugal

2016

Physiological and Biochemical Zoology

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Avian embryos are a commonly used model system for developmental studies, but monitoring of physiological parameters such as heart rate (HR) and movement in ovo poses a challenge to researchers. These are also increasingly common research objectives for ecological and embryo behavior studies in oviparous species. We therefore explored the validity of a new digital egg-monitoring system for the noninvasive monitoring of these parameters. We tested the relationship between frequency-ofmovement values gathered by digital monitoring and those gathered by the current standard method, which is comparatively invasive and requires egg windowing, and demonstrated that the digital monitoring method effectively distinguishes individual movements but cannot reliably monitor HR in actively motile embryos. We therefore provide recommendations for the appropriate use of this technique for avian physiologists. We also applied the digital monitoring method to reveal how frequency of movement varies throughout prenatal ontogeny in the chicken and showed that commonly used protocols in developmental studies can themselves alter motility; egg windowing and application of light modulate frequency of movement. Recent work has revealed the importance of embryo motility in regulating gene expression and cellular activity during developmental processes. Together with our data, this highlights the value of noninvasive monitoring methods and the importance of controlling for altered embryo motility/behavior in developmental studies.

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“…11,13 Experimentally, normal synovium was formed by local mechanical disruption of the connective tissues in vivo. 20 Synovial cell-like cells can be differentiated from mesenchymal stem cells during the wound healing process. A history of trauma was not noted in our case; however, long-term systemic corticosteroid administration may have increased tissue fragility and led to CMSC formation.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metaplastic Synovial Cyst: Case Report and Literature Review from the Dermatological Point of View

et al. 2016

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Cutaneous metaplastic synovial cysts (CMSCs) are rare tumors typically comprising a solitary, wellcircumscribed cystic mass that is not connected to the joint. Synovial cysts have been reported predominantly by orthopedists or pathologists; however, the presence of CMSC is not generally well recognized by dermatologists. Herein, we report a CMSC in a 68-year-old woman receiving systemic corticosteroid therapy for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA). We attempt to delineate the clinical characteristics of this unusual neoplasm by reviewing the literature, focusing especially on dermatological descriptions. Histologic examination of the surgical specimen in the current case revealed that the cystic wall was lined with layers of flattened synovial cell-like cells and connective tissues, mimicking the synovial membrane. Positive immunoreactivity of the lining cells against vimentin was detected, but no immunoreactivity against cytokeratin, carcinoembryonic antigen (CEA), CD68, or S-100 was detected. The pathogenesis of CMSC remains unclear, but it has been tightly linked to direct traumatic stimuli or relative tissue fragility, which potentially accounts for CMSC development in our case. Most CMSCs reported by dermatologists are located on the extremities, whereas those described by other specialists tend to be distributed more globally. Preoperative diagnoses are often either epidermal cyst or suture/foreign body granuloma. Incomplete surgical excision of usual synovial cysts may lead to local recurrence, which has been reported in oral and maxillofacial surgery, but not in dermatologic surgery. This fact could be explained by the technical difficulties of surgical excision related to anatomical location. Dermatologists need to be aware of CMSC, and CMSC should be included in the differential diagnosis of subcutaneous cysts.

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The role of movement in embryonic joint development

Cited by 323 publications

References 23 publications

Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint

Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint

Validating a Noninvasive Technique for Monitoring Embryo Movement In Ovo

Cutaneous Metaplastic Synovial Cyst: Case Report and Literature Review from the Dermatological Point of View

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