The Role of MRI in Differentiating Demyelinating and Inflammatory (not Infectious) Myelopathies

Tamanini, João Vitor Gerdulli; Sabino, João Vitor; Cordeiro, Rafael Alves; Mizubuti, Vanessa; Villarinho, Luciano de Lima; Duarte, Juliana Ávila; Pereira, Fernanda Veloso; Appenzeller, Simone; Damasceno, Alfredo; Reis, Fabiano

doi:10.1053/j.sult.2023.03.017

Cited by 4 publications

(8 citation statements)

References 243 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distribution of these lesions is often observed in the juxtacortical, periventricular, and infratentorial regions [ 9 , 10 ]. Lesions in the corpus callosum region are observed in approximately 12–40% of NMOSD patients [ 11 ]. These lesions typically affect the ependymal surface and involve a substantial portion of the corpus callosum length [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lesions in the corpus callosum region are observed in approximately 12–40% of NMOSD patients [ 11 ]. These lesions typically affect the ependymal surface and involve a substantial portion of the corpus callosum length [ 11 ]. However, in this particular patient, the observed lesion was characterized by a “callosalseptal interface lesion,” which is a typical lesion pattern observed in MS [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, in this particular patient, the observed lesion was characterized by a “callosalseptal interface lesion,” which is a typical lesion pattern observed in MS [ 7 , 8 ]. Lesions in the spinal cord in NMOSD are typically characterized by longitudinally extensive transverse myelitis involving extensive spinal cord involvement with T2-weighted hyperintensity spanning at least 3 vertebral body segments in length [ 11 ]. These lesions predominantly occur in the central cord, with more than 70% of lesions typically located within the central gray matter [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lesions in the spinal cord in NMOSD are typically characterized by longitudinally extensive transverse myelitis involving extensive spinal cord involvement with T2-weighted hyperintensity spanning at least 3 vertebral body segments in length [ 11 ]. These lesions predominantly occur in the central cord, with more than 70% of lesions typically located within the central gray matter [ 11 ]. Additionally, more than half of spinal cord lesions typically involve more than 50% of the cross-sectional area of the spinal cord [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…These lesions predominantly occur in the central cord, with more than 70% of lesions typically located within the central gray matter [ 11 ]. Additionally, more than half of spinal cord lesions typically involve more than 50% of the cross-sectional area of the spinal cord [ 11 , 12 ]. In contrast, spinal cord lesions in MS are typically short segments with a longitudinal extension of 2 or fewer vertebral bodies [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

An AQP-4-IgG-Positive Patient with Neuroimaging Findings Suggestive of Multiple Sclerosis

Li,

Liu,

Zhou

et al. 2023

Am J Case Rep

View full text Add to dashboard Cite

Patient: Female, 54-year-old Final Diagnosis: Neuromyelitis optica spectrum disorder Symptoms: Recurrent episodes of limb numbness • weakness Clinical Procedure: — Specialty: Neurology Objective: Rare coexistence of disease or pathology Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSDs) are 2 similar but distinct diseases. These diseases were difficult to distinguish from each other until aquaporin-4-IgG (AQP-4-IgG) was discovered. The accurate identification of these 2 diseases is crucial for appropriate drug treatment in clinical practice. Herein, we report a case of AQP-4-IgG seroconversion with magnetic resonance imaging (MRI) findings suggestive of MS. Case Report: A 54-year-old woman developed weakness in her right lower extremity that gradually returned to normal 4 years ago. Recently, she was admitted to the hospital for numbness and weakness of both lower limbs and the right upper limb for more than 10 days. The clinical and MRI features of the patient suggested a high susceptibility for misdiagnosis of MS. However, careful observation of the MRI revealed the presence of atypical MS lesions (“red flag” signs), indicating the possibility of other diagnoses in this patient. After further examination, serum AQP-4-IgG was detected, suggesting the potential presence of another disorder, NMOSD, in the patient. Conclusions: Attention should be given to the identification of MS MRI “red flag” signs. Even for patients with a high suspicion of MS, it is necessary to conduct antibody tests for AQP-4-IgG, MOG-IgG and other relevant markers to screen for associated diseases because MS disease-modifying therapy approaches may lead to a deterioration in the state of NMOSD patients. Analyzing this case can help us to further distinguish the differences between these 2 types of diseases, which has important practical clinical value.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

An AQP-4-IgG-Positive Patient with Neuroimaging Findings Suggestive of Multiple Sclerosis

Li,

Liu,

Zhou

et al. 2023

Am J Case Rep

View full text Add to dashboard Cite

show abstract

Role of Magnetic Resonance Imaging in evaluating T2-weighted hyperintensities in spinal cord in a tertiary care hospital in central India

Dhabalia,

Kashikar

2024

F1000Res

View full text Add to dashboard Cite

Background Hyperintensities on T2-weighted images in the spinal cord are a complex and diagnostically challenging entity that can present with diverse clinical features. This study protocol outlines a comprehensive investigation to understand the causes, clinical and imaging characteristics, and correlation with pathological findings of hyperintensities on T2-weighted images in the spinal cord. By establishing a systematic assessment approach, this study seeks to provide valuable insights into these abnormalities’ diagnostic and prognostic implications. Methods The study will be conducted as a prospective observational design. Patients with clinically diagnosed or suspected spinal cord lesion presenting with intramedullary T2-weighted hyperintensity and referred for MRI evaluation will be included. Data collection will encompass patient demographics, clinical features, and extensive imaging parameters. Pathological data, when available, will be correlated with imaging findings. Various statistical methods will be employed to analyse the data, including frequency analysis, comparative tests, logistic regression, and survival analysis. Expected Results The study anticipates elucidating the spectrum of etiologies underlying hyperintensities on T2-weighted images in the spinal cord and their clinical and imaging profiles. The systematic approach will offer a structured diagnostic method, while correlations with pathological data will provide an enhanced understanding of these conditions. The results are expected to provide clinicians with valuable insights into diagnosing, treating, and prognosticating patients with spinal cord hyperintensities on T2-weighted images.

show abstract

Role of Magnetic Resonance Imaging in evaluating T2-weighted hyperintensities in spinal cord in a tertiary care hospital in central India

Dhabalia,

Kashikar

2024

F1000Res

View full text Add to dashboard Cite

show abstract

The Role of MRI in Differentiating Demyelinating and Inflammatory (not Infectious) Myelopathies

Cited by 4 publications

References 243 publications

An AQP-4-IgG-Positive Patient with Neuroimaging Findings Suggestive of Multiple Sclerosis

An AQP-4-IgG-Positive Patient with Neuroimaging Findings Suggestive of Multiple Sclerosis

Role of Magnetic Resonance Imaging in evaluating T2-weighted hyperintensities in spinal cord in a tertiary care hospital in central India

Role of Magnetic Resonance Imaging in evaluating T2-weighted hyperintensities in spinal cord in a tertiary care hospital in central India

Contact Info

Product

Resources

About